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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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April 2004 Volume 11 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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April 2004 Volume 11 Issue 4

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Article

Expression of ERα, ERβ and Ki-67 in primary tumors and lymph node metastases in breast cancer

  • Authors:
    • Mariusz Koda
    • Stanislaw Sulkowski
    • Luiza Kanczuga-Koda
    • Eva Surmacz
    • Mariola Sulkowska

  • View Affiliations / Copyright

    Affiliations: Department of Clinical Pathology, Medical University of Bialystok, 15-269 Bialystok, Poland. kodamar@zeus.amb.edu.pl
  • Pages: 753-759
    |
    Published online on: April 1, 2004
       https://doi.org/10.3892/or.11.4.753
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Abstract

The success of current hormonal therapies used in breast cancer patients often depends on estrogen receptor (ER) status. The simultaneous pathological assessment of primary breast tumors (PTs) and metastases to regional lymph nodes (MRLNs) could improve the effectiveness of this treatment, but is rarely performed. Consequently, we studied by immunohistochemistry the expression of ERα (ERα), ERβ (ERβ), and the proliferation marker (Ki-67) in PTs and matching MRLNs. The expression of each ERα, ERβ, and Ki-67 positively correlated between PTs and MRLNs (r=0.751, p<0.0001; r=0.391, p<0.03; and r=0.707, p<0.0001, respectively). A negative correlation between the expression of ERα and Ki-67 was found in PTs (r=−0.678, p<0.001) and MRLNs (r=−0.501, p<0.005). A negative correlation between ERα and Ki-67 was also observed in PTs vs. MRLNs (r=−0.619, p<0.0001). Moreover, the expression of ERα and Ki-67 was not associated with nodal status, contrary to ERβ expression, which correlated with negative axillary node status. The results indicated that the associations among ERα, ERβ, and Ki-67 are maintained in PTs and MRLNs. Thus, simultaneous assessment of selected markers in PT and MRLN might help in understanding the mechanisms of breast cancer progression as well as result in the development of new principles for diagnosis and individual therapy planning of estrogen dependent cancer.

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Copy and paste a formatted citation
Spandidos Publications style
Koda M, Sulkowski S, Kanczuga-Koda L, Surmacz E and Sulkowska M: Expression of ERα, ERβ and Ki-67 in primary tumors and lymph node metastases in breast cancer. Oncol Rep 11: 753-759, 2004.
APA
Koda, M., Sulkowski, S., Kanczuga-Koda, L., Surmacz, E., & Sulkowska, M. (2004). Expression of ERα, ERβ and Ki-67 in primary tumors and lymph node metastases in breast cancer. Oncology Reports, 11, 753-759. https://doi.org/10.3892/or.11.4.753
MLA
Koda, M., Sulkowski, S., Kanczuga-Koda, L., Surmacz, E., Sulkowska, M."Expression of ERα, ERβ and Ki-67 in primary tumors and lymph node metastases in breast cancer". Oncology Reports 11.4 (2004): 753-759.
Chicago
Koda, M., Sulkowski, S., Kanczuga-Koda, L., Surmacz, E., Sulkowska, M."Expression of ERα, ERβ and Ki-67 in primary tumors and lymph node metastases in breast cancer". Oncology Reports 11, no. 4 (2004): 753-759. https://doi.org/10.3892/or.11.4.753
Copy and paste a formatted citation
x
Spandidos Publications style
Koda M, Sulkowski S, Kanczuga-Koda L, Surmacz E and Sulkowska M: Expression of ERα, ERβ and Ki-67 in primary tumors and lymph node metastases in breast cancer. Oncol Rep 11: 753-759, 2004.
APA
Koda, M., Sulkowski, S., Kanczuga-Koda, L., Surmacz, E., & Sulkowska, M. (2004). Expression of ERα, ERβ and Ki-67 in primary tumors and lymph node metastases in breast cancer. Oncology Reports, 11, 753-759. https://doi.org/10.3892/or.11.4.753
MLA
Koda, M., Sulkowski, S., Kanczuga-Koda, L., Surmacz, E., Sulkowska, M."Expression of ERα, ERβ and Ki-67 in primary tumors and lymph node metastases in breast cancer". Oncology Reports 11.4 (2004): 753-759.
Chicago
Koda, M., Sulkowski, S., Kanczuga-Koda, L., Surmacz, E., Sulkowska, M."Expression of ERα, ERβ and Ki-67 in primary tumors and lymph node metastases in breast cancer". Oncology Reports 11, no. 4 (2004): 753-759. https://doi.org/10.3892/or.11.4.753
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