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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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April 2004 Volume 11 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Endothelin-1, Endothelin-A- and Endothelin-B-receptor expression in preinvasive and invasive breast disease

  • Authors:
    • Pia Wülfing
    • Raihanatou Diallo
    • Christian Kersting
    • Christian Wülfing
    • Christopher Poremba
    • Robert R. Greb
    • Werner Böcker
    • Ludwig Kiesel

  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, University of Münster, D-48149 Münster, Germany. wuelfip@uni-muenster.de
  • Pages: 791-796
    |
    Published online on: April 1, 2004
       https://doi.org/10.3892/or.11.4.791
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Abstract

Endothelin-1 (ET-1) is overexpressed in breast carcinomas and influences via its receptors (ETAR and ETBR) transformation, differentiation and growth processes in the human breast, but little is known about the ET expression in breast cancer precursors. On this basis we evaluated the expression of ET-1, ETAR and ETBR in a series of breast carcinomas, ductal (DCIS) and lobular carcinoma in situ (LCIS) and normal breast tissue by immunohistochemical (IH) methods. IH staining of ET-1, ETAR and ETBR was performed in 88 invasive breast carcinomas, with adjacent carcinoma in situ and concomitant normal breast tissue. Moderate or strong cytoplasmic immunostaining was observed for ET-1 in 33.3%, for ETAR in 45.3% and for ETBR in 55.7% of invasive breast carcinomas. Comparative analysis of invasive cancer (CA), concomitant carcinoma in situ (CIS) and normal breast epithelium (NBE) revealed a stepwise increase of ET-1 and ETAR expression in the sequence NBE < CIS < CA. ETBR expression tended to be slightly higher in CIS than in CA (NBE versus CIS and NBE versus CA, for ETAR and ETBR, p<0.001, respectively; NBE versus CA for ET-1, p=0.035). Our data suggest that the expression of ET-1, ETAR and ETBR correlates with the acquisition of malignant potential and may be used as a prognostic indicator of aggressive behaviour and invasive potential of premalignant breast lesions.

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Copy and paste a formatted citation
Spandidos Publications style
Wülfing P, Diallo R, Kersting C, Wülfing C, Poremba C, Greb RR, Böcker W and Kiesel L: Endothelin-1, Endothelin-A- and Endothelin-B-receptor expression in preinvasive and invasive breast disease. Oncol Rep 11: 791-796, 2004.
APA
Wülfing, P., Diallo, R., Kersting, C., Wülfing, C., Poremba, C., Greb, R.R. ... Kiesel, L. (2004). Endothelin-1, Endothelin-A- and Endothelin-B-receptor expression in preinvasive and invasive breast disease. Oncology Reports, 11, 791-796. https://doi.org/10.3892/or.11.4.791
MLA
Wülfing, P., Diallo, R., Kersting, C., Wülfing, C., Poremba, C., Greb, R. R., Böcker, W., Kiesel, L."Endothelin-1, Endothelin-A- and Endothelin-B-receptor expression in preinvasive and invasive breast disease". Oncology Reports 11.4 (2004): 791-796.
Chicago
Wülfing, P., Diallo, R., Kersting, C., Wülfing, C., Poremba, C., Greb, R. R., Böcker, W., Kiesel, L."Endothelin-1, Endothelin-A- and Endothelin-B-receptor expression in preinvasive and invasive breast disease". Oncology Reports 11, no. 4 (2004): 791-796. https://doi.org/10.3892/or.11.4.791
Copy and paste a formatted citation
x
Spandidos Publications style
Wülfing P, Diallo R, Kersting C, Wülfing C, Poremba C, Greb RR, Böcker W and Kiesel L: Endothelin-1, Endothelin-A- and Endothelin-B-receptor expression in preinvasive and invasive breast disease. Oncol Rep 11: 791-796, 2004.
APA
Wülfing, P., Diallo, R., Kersting, C., Wülfing, C., Poremba, C., Greb, R.R. ... Kiesel, L. (2004). Endothelin-1, Endothelin-A- and Endothelin-B-receptor expression in preinvasive and invasive breast disease. Oncology Reports, 11, 791-796. https://doi.org/10.3892/or.11.4.791
MLA
Wülfing, P., Diallo, R., Kersting, C., Wülfing, C., Poremba, C., Greb, R. R., Böcker, W., Kiesel, L."Endothelin-1, Endothelin-A- and Endothelin-B-receptor expression in preinvasive and invasive breast disease". Oncology Reports 11.4 (2004): 791-796.
Chicago
Wülfing, P., Diallo, R., Kersting, C., Wülfing, C., Poremba, C., Greb, R. R., Böcker, W., Kiesel, L."Endothelin-1, Endothelin-A- and Endothelin-B-receptor expression in preinvasive and invasive breast disease". Oncology Reports 11, no. 4 (2004): 791-796. https://doi.org/10.3892/or.11.4.791
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