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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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April 2004 Volume 11 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Medicine International

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Article

Glycerol enhances CDDP-induced growth inhibition of thyroid anaplastic carcinoma tumor carrying mutated p53 genet

  • Authors:
    • Kazue Yuki
    • Akihisa Takahashi
    • Ichiro Ota
    • Ken Ohnishi
    • Jun-Ichi Yasumoto
    • Hirokazu Kanata
    • Katsunari Yane
    • Hiroshi Hosoi
    • Takeo Ohnishi

  • View Affiliations / Copyright

    Affiliations: Department of Otorhinolaryngology, Nara Medical University, Kashihara, Nara 634-8521, Japan
  • Pages: 821-824
    |
    Published online on: April 1, 2004
       https://doi.org/10.3892/or.11.4.821
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Abstract

To increase the chemo-sensitivity of anaplastic thyroid carcinoma, we examined the effects of glycerol on the tumor growth after CDDP treatment. The cultured cells of an anaplastic thyroid carcinoma cell line (8305c) carrying a mutated p53 gene (mp53) were transplanted into the thighs of nude mice. Tumor growth was evaluated until 24 days after intraperitoneal injection of CDDP and/or pre-injection of glycerol to the tumor. We treated the mice with half the tumor volume of glycerol (1.2 M) and/or CDDP at 6 mg/kg (BW) either of which hardly inhibited tumor growth by itself. When we treated the mice with the combination of glycerol and CDDP at these concentrations, however, a clear delay of the tumor growth was observed. We also immunohistochemically analyzed the effects of glycerol on the induction of caspase-3 activity and apoptosis. Cells positive for cleavage to active caspase-3 and 85 kDa PARP, and apoptosis were hardly observed in the tumors when they were treated with glycerol or CDDP alone. In contrast, when they were treated with CDDP combined with glycerol, such positive cells were significantly increased. It has been shown that glycerol synergistically enhanced the effects of CDDP as a tumor suppressive agent through the induction of caspase-3-mediated apoptosis in 8305c tumors. Therefore, glycerol might be useful for chemotherapy in patients with mp53 cancer cells.

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Copy and paste a formatted citation
Spandidos Publications style
Yuki K, Takahashi A, Ota I, Ohnishi K, Yasumoto J, Kanata H, Yane K, Hosoi H and Ohnishi T: Glycerol enhances CDDP-induced growth inhibition of thyroid anaplastic carcinoma tumor carrying mutated p53 genet. Oncol Rep 11: 821-824, 2004.
APA
Yuki, K., Takahashi, A., Ota, I., Ohnishi, K., Yasumoto, J., Kanata, H. ... Ohnishi, T. (2004). Glycerol enhances CDDP-induced growth inhibition of thyroid anaplastic carcinoma tumor carrying mutated p53 genet. Oncology Reports, 11, 821-824. https://doi.org/10.3892/or.11.4.821
MLA
Yuki, K., Takahashi, A., Ota, I., Ohnishi, K., Yasumoto, J., Kanata, H., Yane, K., Hosoi, H., Ohnishi, T."Glycerol enhances CDDP-induced growth inhibition of thyroid anaplastic carcinoma tumor carrying mutated p53 genet". Oncology Reports 11.4 (2004): 821-824.
Chicago
Yuki, K., Takahashi, A., Ota, I., Ohnishi, K., Yasumoto, J., Kanata, H., Yane, K., Hosoi, H., Ohnishi, T."Glycerol enhances CDDP-induced growth inhibition of thyroid anaplastic carcinoma tumor carrying mutated p53 genet". Oncology Reports 11, no. 4 (2004): 821-824. https://doi.org/10.3892/or.11.4.821
Copy and paste a formatted citation
x
Spandidos Publications style
Yuki K, Takahashi A, Ota I, Ohnishi K, Yasumoto J, Kanata H, Yane K, Hosoi H and Ohnishi T: Glycerol enhances CDDP-induced growth inhibition of thyroid anaplastic carcinoma tumor carrying mutated p53 genet. Oncol Rep 11: 821-824, 2004.
APA
Yuki, K., Takahashi, A., Ota, I., Ohnishi, K., Yasumoto, J., Kanata, H. ... Ohnishi, T. (2004). Glycerol enhances CDDP-induced growth inhibition of thyroid anaplastic carcinoma tumor carrying mutated p53 genet. Oncology Reports, 11, 821-824. https://doi.org/10.3892/or.11.4.821
MLA
Yuki, K., Takahashi, A., Ota, I., Ohnishi, K., Yasumoto, J., Kanata, H., Yane, K., Hosoi, H., Ohnishi, T."Glycerol enhances CDDP-induced growth inhibition of thyroid anaplastic carcinoma tumor carrying mutated p53 genet". Oncology Reports 11.4 (2004): 821-824.
Chicago
Yuki, K., Takahashi, A., Ota, I., Ohnishi, K., Yasumoto, J., Kanata, H., Yane, K., Hosoi, H., Ohnishi, T."Glycerol enhances CDDP-induced growth inhibition of thyroid anaplastic carcinoma tumor carrying mutated p53 genet". Oncology Reports 11, no. 4 (2004): 821-824. https://doi.org/10.3892/or.11.4.821
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