Possible distinct molecular carcinogenic pathways for bladder cancer in Ukraine, before and after the Chernobyl disaster

  • Authors:
    • Keiichirou Morimura
    • Alina Romanenko
    • Wei Min
    • Elsayed I. Salim
    • Anna Kinoshita
    • Hideki Wanibuchi
    • Alexander Vozianov
    • Shoji Fukushima
  • View Affiliations

  • Published online on: April 1, 2004     https://doi.org/10.3892/or.11.4.881
  • Pages: 881-886
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Abstract

After the Chernobyl accident in 1986, the incidence of urinary bladder cancers in the Ukraine increased gradually from 26.2 to 43.3 per 100,000 people between 1986 and 2001. In the areas of low level but persistent cesium-137 (137Cs) radio-contamination, a unique atypical radiation-related urinary bladder cystitis named ‘Chernobyl cystitis’, a possible pre-neoplastic condition in humans, has been detected. We have previously documented high incidences of bladder lesions, including severe dysplasias and/or carcinoma in situ, in association with this cystitis and correlating with oxidative DNA damage. To further investigate the molecular mechanisms underlying bladder carcinogenesis with this specific etiology, mutation analysis of p53 gene (exon 5-8) was performed for 11 and 18 paraffin-embedded bladder cancers in Ukrainians, respectively collected before and after the Chernobyl disaster. DNAs were extracted and subjected to nested PCR-single-strand conformational polymorphism analysis followed by direct DNA sequencing, as well as p53 immunohistochemistry (IHC). The incidences of p53 gene mutation were 54.5 and 16.7% for before and after the Chernobyl disaster, respectively, the difference being statistically significant. Also a tendency for higher p53 IHC score was apparent in the earlier group of lesions. No significant difference was noted for the proportions of historical types. These results point to possible distinct molecular carcinogenic pathways of bladder cancer formation, before and after the Chernobyl disaster, on the basis of variation in p53 gene alteration.

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April 2004
Volume 11 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Morimura K, Romanenko A, Min W, Salim EI, Kinoshita A, Wanibuchi H, Vozianov A and Fukushima S: Possible distinct molecular carcinogenic pathways for bladder cancer in Ukraine, before and after the Chernobyl disaster. Oncol Rep 11: 881-886, 2004
APA
Morimura, K., Romanenko, A., Min, W., Salim, E.I., Kinoshita, A., Wanibuchi, H. ... Fukushima, S. (2004). Possible distinct molecular carcinogenic pathways for bladder cancer in Ukraine, before and after the Chernobyl disaster. Oncology Reports, 11, 881-886. https://doi.org/10.3892/or.11.4.881
MLA
Morimura, K., Romanenko, A., Min, W., Salim, E. I., Kinoshita, A., Wanibuchi, H., Vozianov, A., Fukushima, S."Possible distinct molecular carcinogenic pathways for bladder cancer in Ukraine, before and after the Chernobyl disaster". Oncology Reports 11.4 (2004): 881-886.
Chicago
Morimura, K., Romanenko, A., Min, W., Salim, E. I., Kinoshita, A., Wanibuchi, H., Vozianov, A., Fukushima, S."Possible distinct molecular carcinogenic pathways for bladder cancer in Ukraine, before and after the Chernobyl disaster". Oncology Reports 11, no. 4 (2004): 881-886. https://doi.org/10.3892/or.11.4.881