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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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April 2004 Volume 11 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Single nucleotide polymorphisms in breast cancer

  • Authors:
    • Asta Försti
    • Sabrina Angelini
    • Fabiola Festa
    • Somali Sanyal
    • Zhenzhong Zhang
    • Ewa Grzybowska
    • Jolanta Pamula
    • Wioletta Pekala
    • Helena Zientek
    • Kari Hemminki
    • Rajiv Kumar

  • View Affiliations / Copyright

    Affiliations: Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany. a.foersti@dkfz.de
  • Pages: 917-922
    |
    Published online on: April 1, 2004
       https://doi.org/10.3892/or.11.4.917
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Abstract

A limited number of genes have been identified that explain heritable risks of breast cancer (BC). We searched for low-penetrant genes in an association study using two populations: 223 Finnish unselected patients and 172 Polish familial cases, both with locally collected healthy controls. Candidate genes included DNA repair genes, methylenetetrahydrofolate reductase (MTHFR) and cyclin D1 genes. The frequencies for single nucleotide polymorphisms (SNPs) were measured in the following genes: NBS1, XPC, XPD, XRCC1, XRCC3, MTHFR, and cyclin D1. Odds ratios (ORs) were calculated to the wild-type genotype. The positive findings in the Finnish series were repeated in the Polish series. Significant findings among Finns were associations to XPC exon 15, XPD exon 10 and XRCC3 exon 7, the latter of borderline significance. None of these results could be repeated in the Polish series. The XPC result among Finns was probably an artifact of the control group deviating from the Hardy-Weinberg Equilibrium (HWE). The attempt to repeat the result for the XPD polymorphism among Poles was probably not valid because the control group deviated from the HWE. We conclude that within statistical power of the present study, none of the tested polymorphisms associated with BC, with the probable exception of XPD.

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Copy and paste a formatted citation
Spandidos Publications style
Försti A, Angelini S, Festa F, Sanyal S, Zhang Z, Grzybowska E, Pamula J, Pekala W, Zientek H, Hemminki K, Hemminki K, et al: Single nucleotide polymorphisms in breast cancer. Oncol Rep 11: 917-922, 2004.
APA
Försti, A., Angelini, S., Festa, F., Sanyal, S., Zhang, Z., Grzybowska, E. ... Kumar, R. (2004). Single nucleotide polymorphisms in breast cancer. Oncology Reports, 11, 917-922. https://doi.org/10.3892/or.11.4.917
MLA
Försti, A., Angelini, S., Festa, F., Sanyal, S., Zhang, Z., Grzybowska, E., Pamula, J., Pekala, W., Zientek, H., Hemminki, K., Kumar, R."Single nucleotide polymorphisms in breast cancer". Oncology Reports 11.4 (2004): 917-922.
Chicago
Försti, A., Angelini, S., Festa, F., Sanyal, S., Zhang, Z., Grzybowska, E., Pamula, J., Pekala, W., Zientek, H., Hemminki, K., Kumar, R."Single nucleotide polymorphisms in breast cancer". Oncology Reports 11, no. 4 (2004): 917-922. https://doi.org/10.3892/or.11.4.917
Copy and paste a formatted citation
x
Spandidos Publications style
Försti A, Angelini S, Festa F, Sanyal S, Zhang Z, Grzybowska E, Pamula J, Pekala W, Zientek H, Hemminki K, Hemminki K, et al: Single nucleotide polymorphisms in breast cancer. Oncol Rep 11: 917-922, 2004.
APA
Försti, A., Angelini, S., Festa, F., Sanyal, S., Zhang, Z., Grzybowska, E. ... Kumar, R. (2004). Single nucleotide polymorphisms in breast cancer. Oncology Reports, 11, 917-922. https://doi.org/10.3892/or.11.4.917
MLA
Försti, A., Angelini, S., Festa, F., Sanyal, S., Zhang, Z., Grzybowska, E., Pamula, J., Pekala, W., Zientek, H., Hemminki, K., Kumar, R."Single nucleotide polymorphisms in breast cancer". Oncology Reports 11.4 (2004): 917-922.
Chicago
Försti, A., Angelini, S., Festa, F., Sanyal, S., Zhang, Z., Grzybowska, E., Pamula, J., Pekala, W., Zientek, H., Hemminki, K., Kumar, R."Single nucleotide polymorphisms in breast cancer". Oncology Reports 11, no. 4 (2004): 917-922. https://doi.org/10.3892/or.11.4.917
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