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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
Journal Cover
May 2004 Volume 11 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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May 2004 Volume 11 Issue 5

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Article

Effect of short-term morphine exposure on P-glycoprotein expression and activity in cancer cell lines

  • Authors:
    • Marina Pajic
    • Mary Bebawy
    • Janelle M. Hoskins
    • Basil D. Roufogalis
    • Laurent P. Rivory

  • View Affiliations / Copyright

    Affiliations: Children's Cancer Institute of Australia for Medical Research, Randwick, Sydney, NSW 2031, Australia. mpajic@ccia.org.au
  • Pages: 1091-1095
    |
    Published online on: May 1, 2004
       https://doi.org/10.3892/or.11.5.1091
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Abstract

Multidrug resistance (MDR) is a common problem in various types of cancer. One important factor in the development of MDR is overexpression of P-glycoprotein, encoded by the MDR1 gene. Morphine is the opioid of choice for moderate to severe cancer pain, and is a substrate of P-glycoprotein. Recently, morphine has been shown to induce P-glycoprotein expression in the rat brain. Using Western blot analysis and cytotoxicity assays respectively, we have investigated the effects of short-term (72 h) morphine treatment on P-glycoprotein expression in a panel of human cancer cell lines, and its effects on cellular resistance to the known P-glycoprotein substrates, vinblastine and colchicine. The effect of morphine on P-glycoprotein expression and activity in the mouse fibroblast NIH-3T3 cell was assessed to establish whether morphine effects are species specific. Short-term exposure to morphine did not result in any significant differences in P-glycoprotein expression or activity in any cancer cell lines. Morphine pre-treatment resulted in a moderate but significant increase in sensitivity of NIH-3T3 cells to vinblastine, but not colchicine. This study suggests that morphine effects may be cell-type specific. Importantly, however, it appears that short-term morphine treatment does not affect the MDR phenotype of tumour cells.

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Copy and paste a formatted citation
Spandidos Publications style
Pajic M, Bebawy M, Hoskins JM, Roufogalis BD and Rivory LP: Effect of short-term morphine exposure on P-glycoprotein expression and activity in cancer cell lines. Oncol Rep 11: 1091-1095, 2004.
APA
Pajic, M., Bebawy, M., Hoskins, J.M., Roufogalis, B.D., & Rivory, L.P. (2004). Effect of short-term morphine exposure on P-glycoprotein expression and activity in cancer cell lines. Oncology Reports, 11, 1091-1095. https://doi.org/10.3892/or.11.5.1091
MLA
Pajic, M., Bebawy, M., Hoskins, J. M., Roufogalis, B. D., Rivory, L. P."Effect of short-term morphine exposure on P-glycoprotein expression and activity in cancer cell lines". Oncology Reports 11.5 (2004): 1091-1095.
Chicago
Pajic, M., Bebawy, M., Hoskins, J. M., Roufogalis, B. D., Rivory, L. P."Effect of short-term morphine exposure on P-glycoprotein expression and activity in cancer cell lines". Oncology Reports 11, no. 5 (2004): 1091-1095. https://doi.org/10.3892/or.11.5.1091
Copy and paste a formatted citation
x
Spandidos Publications style
Pajic M, Bebawy M, Hoskins JM, Roufogalis BD and Rivory LP: Effect of short-term morphine exposure on P-glycoprotein expression and activity in cancer cell lines. Oncol Rep 11: 1091-1095, 2004.
APA
Pajic, M., Bebawy, M., Hoskins, J.M., Roufogalis, B.D., & Rivory, L.P. (2004). Effect of short-term morphine exposure on P-glycoprotein expression and activity in cancer cell lines. Oncology Reports, 11, 1091-1095. https://doi.org/10.3892/or.11.5.1091
MLA
Pajic, M., Bebawy, M., Hoskins, J. M., Roufogalis, B. D., Rivory, L. P."Effect of short-term morphine exposure on P-glycoprotein expression and activity in cancer cell lines". Oncology Reports 11.5 (2004): 1091-1095.
Chicago
Pajic, M., Bebawy, M., Hoskins, J. M., Roufogalis, B. D., Rivory, L. P."Effect of short-term morphine exposure on P-glycoprotein expression and activity in cancer cell lines". Oncology Reports 11, no. 5 (2004): 1091-1095. https://doi.org/10.3892/or.11.5.1091
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