Molecular cytogenetic characterisation of the colorectal cancer cell line SW480

  • Authors:
    • Jordi Camps
    • Kristin Mrasek
    • Esther Prat
    • Anja Weise
    • Heike Starke
    • Josep Egozcue
    • Rosa Miró
    • Thomas Liehr
  • View Affiliations

  • Published online on: June 1, 2004     https://doi.org/10.3892/or.11.6.1215
  • Pages: 1215-1218
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Abstract

It has been demonstrated that 24-color FISH is not sufficient to understand completely the behaviour of chromosomal markers, especially in solid tumors. In the present study we show the usefulness of molecular cyto-genetic techniques, such as multicolour banding (MCB) and centromere-specific multicolour-FISH (cenM-FISH) performed on the colorectal cancer cell line SW480. Applying these approaches previously described chromosomal breakpoints could be redefined and six ‘marker chromosomes’ could be thoroughly characterised. Additionally, the cenM-FISH technique identified three stable dicentric chromosomes which have never been described before in SW480. In conclusion, here we present the first comprehensive characterisation of the complex karyotype of the colorectal cancer cell line SW480.

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June 2004
Volume 11 Issue 6

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Camps J, Mrasek K, Prat E, Weise A, Starke H, Egozcue J, Miró R and Liehr T: Molecular cytogenetic characterisation of the colorectal cancer cell line SW480. Oncol Rep 11: 1215-1218, 2004
APA
Camps, J., Mrasek, K., Prat, E., Weise, A., Starke, H., Egozcue, J. ... Liehr, T. (2004). Molecular cytogenetic characterisation of the colorectal cancer cell line SW480. Oncology Reports, 11, 1215-1218. https://doi.org/10.3892/or.11.6.1215
MLA
Camps, J., Mrasek, K., Prat, E., Weise, A., Starke, H., Egozcue, J., Miró, R., Liehr, T."Molecular cytogenetic characterisation of the colorectal cancer cell line SW480". Oncology Reports 11.6 (2004): 1215-1218.
Chicago
Camps, J., Mrasek, K., Prat, E., Weise, A., Starke, H., Egozcue, J., Miró, R., Liehr, T."Molecular cytogenetic characterisation of the colorectal cancer cell line SW480". Oncology Reports 11, no. 6 (2004): 1215-1218. https://doi.org/10.3892/or.11.6.1215