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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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July 2004 Volume 12 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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July 2004 Volume 12 Issue 1

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Article

Less frequent promoter hypermethylation of DLC-1 gene in primary breast cancers

  • Authors:
    • Atsushi Teramoto
    • Kazunori Tsukuda
    • Masaaki Yano
    • Shinichi Toyooka
    • Hideaki Dote
    • Hiroyoshi Doihara
    • Nobuyoshi Shimizu

  • View Affiliations / Copyright

    Affiliations: Department of Cancer and Thoracic Surgery, Okayama University Graduate School of Medicine and Dentistry, Okayama 700-8558, Japan
  • Pages: 141-144
    |
    Published online on: July 1, 2004
       https://doi.org/10.3892/or.12.1.141
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Abstract

Absence or low expression of DLC-1, a tumor suppressor gene, in breast cancers has been shown recently. LOH of 8p12-p22, on which DLC-1 is located, is frequent in breast cancers, but the correlation between low expression of DLC-1 and LOH has not been confirmed. To determine the implication of aberrant methylation, one of the most frequent mechanisms of silencing the tumor suppressor or cancer-related genes, we examined the methylation status of DLC-1 promoter region in breast cancer cell lines and primary breast tumors. The hypermethylation status was examined by MSP and 25% of cell lines harbored a methylated allele. The gene silencing by methylation was also confirmed by the re-expression of DLC-1 by the 5-aza-2'-deoxycytidine treatment in DLC-1 hypermethylated cell line. But the methylation of DLC-1 gene was less frequently shown in primary breast cancers (10%). These data suggest that hypermethylation is responsible for silencing of DLC-1 gene in a limited portion of breast cancers.

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Copy and paste a formatted citation
Spandidos Publications style
Teramoto A, Tsukuda K, Yano M, Toyooka S, Dote H, Doihara H and Shimizu N: Less frequent promoter hypermethylation of DLC-1 gene in primary breast cancers. Oncol Rep 12: 141-144, 2004.
APA
Teramoto, A., Tsukuda, K., Yano, M., Toyooka, S., Dote, H., Doihara, H., & Shimizu, N. (2004). Less frequent promoter hypermethylation of DLC-1 gene in primary breast cancers. Oncology Reports, 12, 141-144. https://doi.org/10.3892/or.12.1.141
MLA
Teramoto, A., Tsukuda, K., Yano, M., Toyooka, S., Dote, H., Doihara, H., Shimizu, N."Less frequent promoter hypermethylation of DLC-1 gene in primary breast cancers". Oncology Reports 12.1 (2004): 141-144.
Chicago
Teramoto, A., Tsukuda, K., Yano, M., Toyooka, S., Dote, H., Doihara, H., Shimizu, N."Less frequent promoter hypermethylation of DLC-1 gene in primary breast cancers". Oncology Reports 12, no. 1 (2004): 141-144. https://doi.org/10.3892/or.12.1.141
Copy and paste a formatted citation
x
Spandidos Publications style
Teramoto A, Tsukuda K, Yano M, Toyooka S, Dote H, Doihara H and Shimizu N: Less frequent promoter hypermethylation of DLC-1 gene in primary breast cancers. Oncol Rep 12: 141-144, 2004.
APA
Teramoto, A., Tsukuda, K., Yano, M., Toyooka, S., Dote, H., Doihara, H., & Shimizu, N. (2004). Less frequent promoter hypermethylation of DLC-1 gene in primary breast cancers. Oncology Reports, 12, 141-144. https://doi.org/10.3892/or.12.1.141
MLA
Teramoto, A., Tsukuda, K., Yano, M., Toyooka, S., Dote, H., Doihara, H., Shimizu, N."Less frequent promoter hypermethylation of DLC-1 gene in primary breast cancers". Oncology Reports 12.1 (2004): 141-144.
Chicago
Teramoto, A., Tsukuda, K., Yano, M., Toyooka, S., Dote, H., Doihara, H., Shimizu, N."Less frequent promoter hypermethylation of DLC-1 gene in primary breast cancers". Oncology Reports 12, no. 1 (2004): 141-144. https://doi.org/10.3892/or.12.1.141
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