Relation between HPV-DNA and expression of p53, bcl-2, p21WAF-1, MIB-1, HER-2/neu and DNA ploidy in early cervical carcinoma: Correlation with clinical outcome

  • Authors:
    • M. Graflund
    • B. Sorbe
    • S. Sigurdardóttir
    • M. G. Karlsson
  • View Affiliations

  • Published online on: July 1, 2004     https://doi.org/10.3892/or.12.1.169
  • Pages: 169-176
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

The purpose of the present study was to analyze the relation between the expression of p53, bcl-2, p21WAF1, MIB-1, HER-2/neu, DNA ploidy and HPV16 or 18 infections with clinical parameters. HPV-DNA was evaluated in 171 early cervical carcinomas treated from 1965 to 1990 and detected by PCR (polymerase chain reaction) on paraffin specimens obtained before therapy was started. HPV-DNA of any type was detected in 78% (86/110) of all tumors, HPV16 was the predominant type and was seen in 56% (62/110), HPV18 in 8% (9/110) and HPV35 in 21% (23/110). Patients with HPV16 or 18 were significantly (P=0.011) younger than patients with tumors not containing these two HPV subtypes. Lymph node metastases were seen more frequently (P=0.047) in tumors expressing HPV16 or 18. Tumor size was associated with the HPV-type. The frequency of DNA aneuploidy was lower in high-risk HPV tumors than in tumors with other HPV subtypes (P=0.014). MIB-1 expression was highly significantly (P=0.00007) associated with presence of HPV16 or 18. The cancer-specific survival rate was lower for patients with HPV16 and 18 positive tumors, but the difference was not statistically significant. The overall 5-year survival rate of the complete series was 91%. In conclusion, the HPV DNA subtype was a prognostic factor in early stage cervical cancer and it was associated with age, positive lymph nodes, tumor size, DNA ploidy and the proliferation marker MIB-1.

Related Articles

Journal Cover

July 2004
Volume 12 Issue 1

Print ISSN: 1021-335X
Online ISSN:1791-2431

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Graflund M, Sorbe B, Sigurdardóttir S and Karlsson MG: Relation between HPV-DNA and expression of p53, bcl-2, p21WAF-1, MIB-1, HER-2/neu and DNA ploidy in early cervical carcinoma: Correlation with clinical outcome. Oncol Rep 12: 169-176, 2004.
APA
Graflund, M., Sorbe, B., Sigurdardóttir, S., & Karlsson, M.G. (2004). Relation between HPV-DNA and expression of p53, bcl-2, p21WAF-1, MIB-1, HER-2/neu and DNA ploidy in early cervical carcinoma: Correlation with clinical outcome. Oncology Reports, 12, 169-176. https://doi.org/10.3892/or.12.1.169
MLA
Graflund, M., Sorbe, B., Sigurdardóttir, S., Karlsson, M. G."Relation between HPV-DNA and expression of p53, bcl-2, p21WAF-1, MIB-1, HER-2/neu and DNA ploidy in early cervical carcinoma: Correlation with clinical outcome". Oncology Reports 12.1 (2004): 169-176.
Chicago
Graflund, M., Sorbe, B., Sigurdardóttir, S., Karlsson, M. G."Relation between HPV-DNA and expression of p53, bcl-2, p21WAF-1, MIB-1, HER-2/neu and DNA ploidy in early cervical carcinoma: Correlation with clinical outcome". Oncology Reports 12, no. 1 (2004): 169-176. https://doi.org/10.3892/or.12.1.169