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Ectopic expression of DICE1 suppresses tumor cell growth

  • Authors:
    • Ilse Wieland
    • Christian Sell
    • Ulrich H. Weidle
    • P. Wieacker

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  • Published online on: August 1, 2004     https://doi.org/10.3892/or.12.2.207
  • Pages: 207-211
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Abstract

The tumor suppressor gene DICE1 is located within a previously reported critical region of loss of heterozygosity on chromosome 13q14.3. Expression of the remaining DICE1 allele is down-regulated in non-small cell lung carcinomas. Ectopic expression of DICE1 cDNA by DICE1-green fluor-escent protein fusion constructs resulted in inhibition of colony formation of human non-small cell lung carcinoma cell line SK-MES-1 and NCI-H520 and prostate carcinoma cell line DU145. In IGF-IR transformed Balb/c 3T3, DICE1 substantially sup-pressed growth in soft agar. These results demonstrate that DICE1 has a growth-suppressing activity and interferes with anchorage-independent growth of IGF-IR transformed tumor cells dependent upon IGF-I signaling.

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Journal Cover

August 2004
Volume 12 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

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  • Journal Metrics
  • Impact Factor: 4.2
  • Ranked Oncology
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  • CiteScore: 8.4
  • CiteScore Rank: Q1: #68/366 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.786
  • SCImago Journal Rank (SJR): 0.812
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Spandidos Publications style
Wieland I, Sell C, Weidle UH and Wieacker P: Ectopic expression of DICE1 suppresses tumor cell growth. Oncol Rep 12: 207-211, 2004
APA
Wieland, I., Sell, C., Weidle, U.H., & Wieacker, P. (2004). Ectopic expression of DICE1 suppresses tumor cell growth. Oncology Reports, 12, 207-211. https://doi.org/10.3892/or.12.2.207
MLA
Wieland, I., Sell, C., Weidle, U. H., Wieacker, P."Ectopic expression of DICE1 suppresses tumor cell growth". Oncology Reports 12.2 (2004): 207-211.
Chicago
Wieland, I., Sell, C., Weidle, U. H., Wieacker, P."Ectopic expression of DICE1 suppresses tumor cell growth". Oncology Reports 12, no. 2 (2004): 207-211. https://doi.org/10.3892/or.12.2.207