Cisplatin enhances the p53-independent apoptosis induced by a topoisomerase I inhibitor (CPT-11) in the lens epithelial tumors in transgenic mice
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- Published online on: August 1, 2004 https://doi.org/10.3892/or.12.2.253
- Pages: 253-258
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Abstract
We reported that CPT-11 could induce apoptosis in mouse lens epithelial tumors when it was administered to pregnant αT3 mice which developed epithelial cell carcinoma in situ in the lens in the perinatal period. p53-deficient αT3 mice were generated to analyze the influence of p53 status on tumor cells under combined chemotherapy. On the 16-18th gestational day, αT3 received a single i.p. administration of both CPT-11 and Cisplatin, and fetal lens epithelial tumors were examined two days later. Apoptosis in the p53-wild-type αT3 tumors was observed in a Cisplatin dose-dependent manner. In addition, it was found that Cisplatin augmented CPT-11-induced p53-independent apoptosis in p53-deficient αT3 mice.
