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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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August 2004 Volume 12 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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August 2004 Volume 12 Issue 2

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Article

Overexpression of cyclooxygenase-2 in childhood ependymomas: Role of COX-2 inhibitor in growth and multi-drug resistance in vitro

  • Authors:
    • Seung-Ki Kim
    • Su-Young Lim
    • Kyu-Chang Wang
    • Young-Yim Kim
    • Je G. Chi
    • Yoon La Choi
    • Hyung Jin Shin
    • Byung-Kyu Cho

  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, Cancer Research Institute, Seoul National University Hospital, Seoul, Korea
  • Pages: 403-409
    |
    Published online on: August 1, 2004
       https://doi.org/10.3892/or.12.2.403
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Abstract

The management of ependymomas remains one of the most frustrating issues in pediatric neuro-oncology. Gross total resection is not always possible, and intensive chemotherapy and craniospinal radiotherapy have made no clear advances. Moreover, the chemoresistance of ependymomas may be explained by the expression of membrane transport molecule P-glycoprotein (P-gp). In this study the expression of cyclooxygenase 2 (COX-2) and the role of the specific COX-2 inhibitor NS-398 in growth and multi-drug resistance of ependymomas were investigated. COX-2 protein expression was assessed in 19 ependymomas immunohistochemically, and the effect of NS-398 on growth and multi-drug resistance was investigated using two primary cultured ependymoma cell lines. COX-2 protein expression was observed in 15 (79%) of the 19 ependymomas. NS-398 was found to reduce the proliferation of monolayer cell cultures in a dose- and time-dependent manner and to induce apoptosis and lower bcl-2 protein levels. After NS-398 treatment, Western blotting showed reduced P-gp expression and a rhodamine 123 efflux assay demonstrated a significant decrease in P-gp activity. Our findings demonstrate that COX-2 is overexpressed in ependymomas and that NS-398 is able to induce apoptosis and suppress P-gp expression and activity.

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Copy and paste a formatted citation
Spandidos Publications style
Kim S, Lim S, Wang K, Kim Y, Chi JG, Choi YL, Shin HJ and Cho B: Overexpression of cyclooxygenase-2 in childhood ependymomas: Role of COX-2 inhibitor in growth and multi-drug resistance in vitro. Oncol Rep 12: 403-409, 2004.
APA
Kim, S., Lim, S., Wang, K., Kim, Y., Chi, J.G., Choi, Y.L. ... Cho, B. (2004). Overexpression of cyclooxygenase-2 in childhood ependymomas: Role of COX-2 inhibitor in growth and multi-drug resistance in vitro. Oncology Reports, 12, 403-409. https://doi.org/10.3892/or.12.2.403
MLA
Kim, S., Lim, S., Wang, K., Kim, Y., Chi, J. G., Choi, Y. L., Shin, H. J., Cho, B."Overexpression of cyclooxygenase-2 in childhood ependymomas: Role of COX-2 inhibitor in growth and multi-drug resistance in vitro". Oncology Reports 12.2 (2004): 403-409.
Chicago
Kim, S., Lim, S., Wang, K., Kim, Y., Chi, J. G., Choi, Y. L., Shin, H. J., Cho, B."Overexpression of cyclooxygenase-2 in childhood ependymomas: Role of COX-2 inhibitor in growth and multi-drug resistance in vitro". Oncology Reports 12, no. 2 (2004): 403-409. https://doi.org/10.3892/or.12.2.403
Copy and paste a formatted citation
x
Spandidos Publications style
Kim S, Lim S, Wang K, Kim Y, Chi JG, Choi YL, Shin HJ and Cho B: Overexpression of cyclooxygenase-2 in childhood ependymomas: Role of COX-2 inhibitor in growth and multi-drug resistance in vitro. Oncol Rep 12: 403-409, 2004.
APA
Kim, S., Lim, S., Wang, K., Kim, Y., Chi, J.G., Choi, Y.L. ... Cho, B. (2004). Overexpression of cyclooxygenase-2 in childhood ependymomas: Role of COX-2 inhibitor in growth and multi-drug resistance in vitro. Oncology Reports, 12, 403-409. https://doi.org/10.3892/or.12.2.403
MLA
Kim, S., Lim, S., Wang, K., Kim, Y., Chi, J. G., Choi, Y. L., Shin, H. J., Cho, B."Overexpression of cyclooxygenase-2 in childhood ependymomas: Role of COX-2 inhibitor in growth and multi-drug resistance in vitro". Oncology Reports 12.2 (2004): 403-409.
Chicago
Kim, S., Lim, S., Wang, K., Kim, Y., Chi, J. G., Choi, Y. L., Shin, H. J., Cho, B."Overexpression of cyclooxygenase-2 in childhood ependymomas: Role of COX-2 inhibitor in growth and multi-drug resistance in vitro". Oncology Reports 12, no. 2 (2004): 403-409. https://doi.org/10.3892/or.12.2.403
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