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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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September 2004 Volume 12 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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September 2004 Volume 12 Issue 3

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Article

Relationship between HPV typing and the status of G2 cell cycle regulators in cervical neoplasia

  • Authors:
    • Yasunori Hashiguchi
    • Hiroshi Tsuda
    • Sadako Nishimura
    • Takeshi Inoue
    • Naoki Kawamura
    • Kumio Yamamoto

  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, Osaka City General Hospital, Miyakojimahondori Miyakojima, Osaka 534-0021, Japan
  • Pages: 587-591
    |
    Published online on: September 1, 2004
       https://doi.org/10.3892/or.12.3.587
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Abstract

We examined human papillomavirus (HPV) typing and the status of ATM, chk2, CDC25C, cdc2 and cyclinB1 in cervical intraepithelial neoplasia (CIN) and invasive cancer (IC). A total of 93 samples [normal: 10; CIN: 34 (CINI:9, CINII:12, CINIII:13); IC: 49 (stage I:10, stage II:21, stage III:15, stage IV:3)] were included in this study. HPV status was evaluated by the PCR non-radioactive HPV detection system. We analyzed ATM, chk2, CDC25C, cdc2 and cyclinB1 protein expression by immunohistochemistry. HPV DNA was detected in 73.5% of 34 CINs and 89.8% of 49 ICs. Detection of HPV subtypes 16 and 18 was more frequent in ICs (46.9%) than in CINs (23.5%) (p=0.0387). Abnormal expression of ATM, chk2, CDC25C, cdc2 and cyclinB1 were 2.9%, 32.4%, 2.9% 20.6% and 0% in CINs and 8.2%, 30.6%, 10.2%, 46.9% and 12.2% in ICs. The alteration of cdc2 was higher in ICs than in CINs (p=0.0198). Altered expression of cdc2 was higher in HPV16 and 18 cases (69.6%) than in other cases (26.9%) (p=0.0042). However, the relationship between HPV typing and ATM, chk2, CDC25C and cyclinB1 expression was not significant. Cdc2 is implicated in cervical carcinogenesis and may be related to p53 inactivation by HPV.

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Copy and paste a formatted citation
Spandidos Publications style
Hashiguchi Y, Tsuda H, Nishimura S, Inoue T, Kawamura N and Yamamoto K: Relationship between HPV typing and the status of G2 cell cycle regulators in cervical neoplasia. Oncol Rep 12: 587-591, 2004.
APA
Hashiguchi, Y., Tsuda, H., Nishimura, S., Inoue, T., Kawamura, N., & Yamamoto, K. (2004). Relationship between HPV typing and the status of G2 cell cycle regulators in cervical neoplasia. Oncology Reports, 12, 587-591. https://doi.org/10.3892/or.12.3.587
MLA
Hashiguchi, Y., Tsuda, H., Nishimura, S., Inoue, T., Kawamura, N., Yamamoto, K."Relationship between HPV typing and the status of G2 cell cycle regulators in cervical neoplasia". Oncology Reports 12.3 (2004): 587-591.
Chicago
Hashiguchi, Y., Tsuda, H., Nishimura, S., Inoue, T., Kawamura, N., Yamamoto, K."Relationship between HPV typing and the status of G2 cell cycle regulators in cervical neoplasia". Oncology Reports 12, no. 3 (2004): 587-591. https://doi.org/10.3892/or.12.3.587
Copy and paste a formatted citation
x
Spandidos Publications style
Hashiguchi Y, Tsuda H, Nishimura S, Inoue T, Kawamura N and Yamamoto K: Relationship between HPV typing and the status of G2 cell cycle regulators in cervical neoplasia. Oncol Rep 12: 587-591, 2004.
APA
Hashiguchi, Y., Tsuda, H., Nishimura, S., Inoue, T., Kawamura, N., & Yamamoto, K. (2004). Relationship between HPV typing and the status of G2 cell cycle regulators in cervical neoplasia. Oncology Reports, 12, 587-591. https://doi.org/10.3892/or.12.3.587
MLA
Hashiguchi, Y., Tsuda, H., Nishimura, S., Inoue, T., Kawamura, N., Yamamoto, K."Relationship between HPV typing and the status of G2 cell cycle regulators in cervical neoplasia". Oncology Reports 12.3 (2004): 587-591.
Chicago
Hashiguchi, Y., Tsuda, H., Nishimura, S., Inoue, T., Kawamura, N., Yamamoto, K."Relationship between HPV typing and the status of G2 cell cycle regulators in cervical neoplasia". Oncology Reports 12, no. 3 (2004): 587-591. https://doi.org/10.3892/or.12.3.587
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