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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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September 2004 Volume 12 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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September 2004 Volume 12 Issue 3

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Article

Prostate-related antigen-derived new peptides having the capacity of inducing prostate cancer-reactive CTLs in HLA-A2+ prostate cancer patients

  • Authors:
    • Mamoru Harada
    • Satoko Matsueda
    • Akihisa Yao
    • Rika Ogata
    • Masanori Noguchi
    • Kyogo Itoh

  • View Affiliations / Copyright

    Affiliations: Department of Immunology, Kurume University School of Medicine, Kurume, Fukuoka 830-0011, Japan. haramamo@med.kurume-u.ac.jp
  • Pages: 601-607
    |
    Published online on: September 1, 2004
       https://doi.org/10.3892/or.12.3.601
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Abstract

Prostate-related antigens, including prostate-specific membrane antigen (PSMA) and prostatic acid phosphatase (PAP), can be targets in specific immunotherapy for prostate cancer. In this study, we attempted to newly identify epitope peptides from these 2 antigens, which are immunogenic in human histocompatibility leukocyte antigen (HLA)-A2+ prostate cancer patients. Twenty-nine peptides (PSMA with 15 and PAP with 14) were prepared based on the HLA-A2 binding motif. Based on our previous finding that antigenic peptides recognized by both cellular and humoral immune systems are useful for peptide-based immunotherapy, peptide candidates were screened first by their ability to be recognized by immunoglobulin G (IgG), and then by their ability to induce peptide-specific cytotoxic T lymphocytes (CTLs). As a result, PSMA441-450 and PAP112-120 peptides were found to be frequently recognized by IgG in plasma from prostate cancer patients. These 2 candidates effectively induced HLA-A2-restricted and prostate cancer-reactive CTLs in HLA-A2+ prostate cancer patients with several HLA-A2 subtypes. In addition, their cytotoxicity was mainly dependent on peptide-specific and CD8+ T cells. These results indicate that these PSMA441-450 and PAP112-120 peptides could be promising candidates for peptide-based immunotherapy for HLA-A2+ prostate cancer.

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Copy and paste a formatted citation
Spandidos Publications style
Harada M, Matsueda S, Yao A, Ogata R, Noguchi M and Itoh K: Prostate-related antigen-derived new peptides having the capacity of inducing prostate cancer-reactive CTLs in HLA-A2+ prostate cancer patients. Oncol Rep 12: 601-607, 2004.
APA
Harada, M., Matsueda, S., Yao, A., Ogata, R., Noguchi, M., & Itoh, K. (2004). Prostate-related antigen-derived new peptides having the capacity of inducing prostate cancer-reactive CTLs in HLA-A2+ prostate cancer patients. Oncology Reports, 12, 601-607. https://doi.org/10.3892/or.12.3.601
MLA
Harada, M., Matsueda, S., Yao, A., Ogata, R., Noguchi, M., Itoh, K."Prostate-related antigen-derived new peptides having the capacity of inducing prostate cancer-reactive CTLs in HLA-A2+ prostate cancer patients". Oncology Reports 12.3 (2004): 601-607.
Chicago
Harada, M., Matsueda, S., Yao, A., Ogata, R., Noguchi, M., Itoh, K."Prostate-related antigen-derived new peptides having the capacity of inducing prostate cancer-reactive CTLs in HLA-A2+ prostate cancer patients". Oncology Reports 12, no. 3 (2004): 601-607. https://doi.org/10.3892/or.12.3.601
Copy and paste a formatted citation
x
Spandidos Publications style
Harada M, Matsueda S, Yao A, Ogata R, Noguchi M and Itoh K: Prostate-related antigen-derived new peptides having the capacity of inducing prostate cancer-reactive CTLs in HLA-A2+ prostate cancer patients. Oncol Rep 12: 601-607, 2004.
APA
Harada, M., Matsueda, S., Yao, A., Ogata, R., Noguchi, M., & Itoh, K. (2004). Prostate-related antigen-derived new peptides having the capacity of inducing prostate cancer-reactive CTLs in HLA-A2+ prostate cancer patients. Oncology Reports, 12, 601-607. https://doi.org/10.3892/or.12.3.601
MLA
Harada, M., Matsueda, S., Yao, A., Ogata, R., Noguchi, M., Itoh, K."Prostate-related antigen-derived new peptides having the capacity of inducing prostate cancer-reactive CTLs in HLA-A2+ prostate cancer patients". Oncology Reports 12.3 (2004): 601-607.
Chicago
Harada, M., Matsueda, S., Yao, A., Ogata, R., Noguchi, M., Itoh, K."Prostate-related antigen-derived new peptides having the capacity of inducing prostate cancer-reactive CTLs in HLA-A2+ prostate cancer patients". Oncology Reports 12, no. 3 (2004): 601-607. https://doi.org/10.3892/or.12.3.601
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