Estrogen receptor α and β, progesterone receptor, pS2 and HER-2/neu expression delineate different subgroups in ductal carcinoma in situ of the breast

  • Authors:
    • Achim Rody
    • Raihanatou Diallo
    • Christopher Poremba
    • Regina Speich
    • Pia Wuelfing
    • Stephen Kissler
    • Christine Solbach
    • Ludwig Kiesel
    • Christian Jackisch
  • View Affiliations

  • Published online on: October 1, 2004     https://doi.org/10.3892/or.12.4.695
  • Pages: 695-699
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Abstract

Antiestrogen therapy of ductal carcinoma in situ (DCIS) has become a more common option in reducing risk of developing invasive cancer. Previously, estrogen receptor α (ER-α) was evaluated as the only predictive factor. Immunohistochemical staining was performed for ER-α, estrogen receptor ER-β, progesterone receptor (PR), pS2 and her-2/neu in 59 cases of ductal carcinoma in situ (DCIS). We observed a positive correlation between the expression of ER-α (p=0.003), PR (p<0.001) and histopathological grading. Of the DCIS, 61.5% of ER-β positive (p=0.046) and 35.5% of PR positive samples showed a coexpression with pS2, whereas 72.1% of pS2 negative DCIS were also negative for ER-β and 92.9% of PR negative DCIS were negative for pS2 (p=0.012). In contrast, 50.0% of her-2/neu negative DCIS expressed ER-β receptor (p=0.052). We propose that there are subpopulations of DCIS which can be described by distinct endocrine-associated expression patterns.

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October 2004
Volume 12 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Rody A, Diallo R, Poremba C, Speich R, Wuelfing P, Kissler S, Solbach C, Kiesel L and Jackisch C: Estrogen receptor α and β, progesterone receptor, pS2 and HER-2/neu expression delineate different subgroups in ductal carcinoma in situ of the breast. Oncol Rep 12: 695-699, 2004.
APA
Rody, A., Diallo, R., Poremba, C., Speich, R., Wuelfing, P., Kissler, S. ... Jackisch, C. (2004). Estrogen receptor α and β, progesterone receptor, pS2 and HER-2/neu expression delineate different subgroups in ductal carcinoma in situ of the breast. Oncology Reports, 12, 695-699. https://doi.org/10.3892/or.12.4.695
MLA
Rody, A., Diallo, R., Poremba, C., Speich, R., Wuelfing, P., Kissler, S., Solbach, C., Kiesel, L., Jackisch, C."Estrogen receptor α and β, progesterone receptor, pS2 and HER-2/neu expression delineate different subgroups in ductal carcinoma in situ of the breast". Oncology Reports 12.4 (2004): 695-699.
Chicago
Rody, A., Diallo, R., Poremba, C., Speich, R., Wuelfing, P., Kissler, S., Solbach, C., Kiesel, L., Jackisch, C."Estrogen receptor α and β, progesterone receptor, pS2 and HER-2/neu expression delineate different subgroups in ductal carcinoma in situ of the breast". Oncology Reports 12, no. 4 (2004): 695-699. https://doi.org/10.3892/or.12.4.695