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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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October 2004 Volume 12 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Medicine International

An International Open Access Journal Devoted to General Medicine.

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October 2004 Volume 12 Issue 4

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Article

Antioxidative response for nitric oxide production in breast carcinoma

  • Authors:
    • Peeter Karihtala
    • Vuokko L. Kinnula
    • Ylermi Soini

  • View Affiliations / Copyright

    Affiliations: Department of Pathology, University of Oulu and Oulu University Hospital, FIN-90014 Oulu, Finland
  • Pages: 755-759
    |
    Published online on: October 1, 2004
       https://doi.org/10.3892/or.12.4.755
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Abstract

Our aim was to study the role of oxidant and nitric oxide (NO)-derived damage in human breast carcinomas by studying the expression of nitrotyrosine in tumor tissue. To elucidate whether nitrotyrosine levels associate with NO synthesis and have an effect on antioxidative enzyme response or angiogenesis, we also studied the expression of all three nitric oxide synthases (NOS), manganese superoxide dismutase (MnSOD), catalase and vascular endothelial growth factor (VEGF) in the tumors. A large set of breast cancer samples in microarray blocks were stained with antibodies to nitrotyrosine, iNOS, eNOS, nNOS, MnSOD, catalase and VEGF. Nitrotyrosine expression was seen in 56% of the cases. There was a close relationship between the expression of nitrotyrosine and all three NOS isoforms (for all p<0.0005), catalase (p<0.0005) and MnSOD (p=0.043), in addition enlarged tumor size was in association with high nitrotyrosine (p=0.046), eNOS (p=0.005) and VEGF (p=0.046) levels. Our findings suggest that NO-derived oxidative damage takes place and its level associates to NOS synthesis in human breast cancer. The current results also imply the attempt of cells to hedge against effects of NO by increasing their MnSOD and catalase expression.

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Copy and paste a formatted citation
Spandidos Publications style
Karihtala P, Kinnula VL and Soini Y: Antioxidative response for nitric oxide production in breast carcinoma. Oncol Rep 12: 755-759, 2004.
APA
Karihtala, P., Kinnula, V.L., & Soini, Y. (2004). Antioxidative response for nitric oxide production in breast carcinoma. Oncology Reports, 12, 755-759. https://doi.org/10.3892/or.12.4.755
MLA
Karihtala, P., Kinnula, V. L., Soini, Y."Antioxidative response for nitric oxide production in breast carcinoma". Oncology Reports 12.4 (2004): 755-759.
Chicago
Karihtala, P., Kinnula, V. L., Soini, Y."Antioxidative response for nitric oxide production in breast carcinoma". Oncology Reports 12, no. 4 (2004): 755-759. https://doi.org/10.3892/or.12.4.755
Copy and paste a formatted citation
x
Spandidos Publications style
Karihtala P, Kinnula VL and Soini Y: Antioxidative response for nitric oxide production in breast carcinoma. Oncol Rep 12: 755-759, 2004.
APA
Karihtala, P., Kinnula, V.L., & Soini, Y. (2004). Antioxidative response for nitric oxide production in breast carcinoma. Oncology Reports, 12, 755-759. https://doi.org/10.3892/or.12.4.755
MLA
Karihtala, P., Kinnula, V. L., Soini, Y."Antioxidative response for nitric oxide production in breast carcinoma". Oncology Reports 12.4 (2004): 755-759.
Chicago
Karihtala, P., Kinnula, V. L., Soini, Y."Antioxidative response for nitric oxide production in breast carcinoma". Oncology Reports 12, no. 4 (2004): 755-759. https://doi.org/10.3892/or.12.4.755
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