Hearing function in soft tissue sarcoma patients after treatment with carboplatin: A report from the Late Effects Surveillance System

  • Authors:
    • W. Stöhr
    • T. Langer
    • A. Kremers
    • I. Brecht
    • J. Treuner
    • A. Dinnesen
    • J. D. Beck
  • View Affiliations

  • Published online on: October 1, 2004     https://doi.org/10.3892/or.12.4.767
  • Pages: 767-771
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Abstract

The aim of this study was to analyse carboplatin-induced ototoxicity in a recent study trial. Twenty patients who had received carboplatin for the treatment of soft tissue sarcoma were investigated prospectively for ototoxicity in a multi-centre trial. Hearing function was tested by audiometry. All patients but one were treated with a cumulative dose of 1500 mg/m2, the remaining with 500 mg/m2. We evaluated the incidence and dependencies of hearing loss, and compared hearing thresholds to those of an untreated control group (n=60). Hearing thresholds in the carboplatin treated group were only marginally poorer compared with those of the control group. After carboplatin therapy no patient (0%; 95%-KI: 0-17%) had a hearing loss >20 dB. Hearing thresholds were not dependent on age, sex or cranial irradiation. We conclude that ototoxicity after carboplatin was low in our group of patients.

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October 2004
Volume 12 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Stöhr W, Langer T, Kremers A, Brecht I, Treuner J, Dinnesen A and Beck JD: Hearing function in soft tissue sarcoma patients after treatment with carboplatin: A report from the Late Effects Surveillance System. Oncol Rep 12: 767-771, 2004
APA
Stöhr, W., Langer, T., Kremers, A., Brecht, I., Treuner, J., Dinnesen, A., & Beck, J.D. (2004). Hearing function in soft tissue sarcoma patients after treatment with carboplatin: A report from the Late Effects Surveillance System. Oncology Reports, 12, 767-771. https://doi.org/10.3892/or.12.4.767
MLA
Stöhr, W., Langer, T., Kremers, A., Brecht, I., Treuner, J., Dinnesen, A., Beck, J. D."Hearing function in soft tissue sarcoma patients after treatment with carboplatin: A report from the Late Effects Surveillance System". Oncology Reports 12.4 (2004): 767-771.
Chicago
Stöhr, W., Langer, T., Kremers, A., Brecht, I., Treuner, J., Dinnesen, A., Beck, J. D."Hearing function in soft tissue sarcoma patients after treatment with carboplatin: A report from the Late Effects Surveillance System". Oncology Reports 12, no. 4 (2004): 767-771. https://doi.org/10.3892/or.12.4.767