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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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October 2004 Volume 12 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Medicine International

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October 2004 Volume 12 Issue 4

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Article

Excision repair cross complementing 3 expression is involved in patient prognosis and tumor progression in esophageal cancer

  • Authors:
    • Yukio Terashita
    • Hideyuki Ishiguro
    • Nobuhiro Haruki
    • Hironori Sugiura
    • Tadashi Tanaka
    • Masahiro Kimura
    • Noriyuki Shinoda
    • Yoshiyuki Kuwabara
    • Yoshitaka Fujii

  • View Affiliations / Copyright

    Affiliations: Second Department of Surgery, Nagoya City University Medical School, Nagoya 467-8601, Japan
  • Pages: 827-831
    |
    Published online on: October 1, 2004
       https://doi.org/10.3892/or.12.4.827
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Abstract

The prognosis of patients with esophageal cancer remains poor. TNM classification is not sufficient to predict the prognosis. Therefore, novel predictive markers of the prognosis of esophageal cancer patients are awaited. The abnormality of the nucleotide excision repair (NER) is often involved in human cancers. Excision repair cross complementing 3 (ERCC3) contributes to NER. In esophageal cancer, ERCC3 expression has not been studied. Expression of ERCC3 was quantified by real-time reverse transcription polymerase chain reaction (RT-PCR) using LightCycler in 43 primary esophageal squamous cell carcinomas (ESCCs) and their paired normal esophageal mucosa. We examined the correlation between the ERCC3 expression and the clinicopathological factors and prognosis of ESCC patients. ERCC3 expression level was significantly correlated with the pathologic stage, tumor size and local invasiveness (t-factor) in esophageal cancer tissues. Reduced expression of ERCC3 was accompanied with tumor progression (p=0.0049) and higher pathologic stage (p=0.020). Moreover, ESCC patients with low ERCC3 mRNA expression had significantly shorter post-operative survival time than those with high expression (p=0.0003). In esophageal cancer, reduced expression of ERCC3 was correlated with local tumor progression and poor prognosis after operation.

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Copy and paste a formatted citation
Spandidos Publications style
Terashita Y, Ishiguro H, Haruki N, Sugiura H, Tanaka T, Kimura M, Shinoda N, Kuwabara Y and Fujii Y: Excision repair cross complementing 3 expression is involved in patient prognosis and tumor progression in esophageal cancer. Oncol Rep 12: 827-831, 2004.
APA
Terashita, Y., Ishiguro, H., Haruki, N., Sugiura, H., Tanaka, T., Kimura, M. ... Fujii, Y. (2004). Excision repair cross complementing 3 expression is involved in patient prognosis and tumor progression in esophageal cancer. Oncology Reports, 12, 827-831. https://doi.org/10.3892/or.12.4.827
MLA
Terashita, Y., Ishiguro, H., Haruki, N., Sugiura, H., Tanaka, T., Kimura, M., Shinoda, N., Kuwabara, Y., Fujii, Y."Excision repair cross complementing 3 expression is involved in patient prognosis and tumor progression in esophageal cancer". Oncology Reports 12.4 (2004): 827-831.
Chicago
Terashita, Y., Ishiguro, H., Haruki, N., Sugiura, H., Tanaka, T., Kimura, M., Shinoda, N., Kuwabara, Y., Fujii, Y."Excision repair cross complementing 3 expression is involved in patient prognosis and tumor progression in esophageal cancer". Oncology Reports 12, no. 4 (2004): 827-831. https://doi.org/10.3892/or.12.4.827
Copy and paste a formatted citation
x
Spandidos Publications style
Terashita Y, Ishiguro H, Haruki N, Sugiura H, Tanaka T, Kimura M, Shinoda N, Kuwabara Y and Fujii Y: Excision repair cross complementing 3 expression is involved in patient prognosis and tumor progression in esophageal cancer. Oncol Rep 12: 827-831, 2004.
APA
Terashita, Y., Ishiguro, H., Haruki, N., Sugiura, H., Tanaka, T., Kimura, M. ... Fujii, Y. (2004). Excision repair cross complementing 3 expression is involved in patient prognosis and tumor progression in esophageal cancer. Oncology Reports, 12, 827-831. https://doi.org/10.3892/or.12.4.827
MLA
Terashita, Y., Ishiguro, H., Haruki, N., Sugiura, H., Tanaka, T., Kimura, M., Shinoda, N., Kuwabara, Y., Fujii, Y."Excision repair cross complementing 3 expression is involved in patient prognosis and tumor progression in esophageal cancer". Oncology Reports 12.4 (2004): 827-831.
Chicago
Terashita, Y., Ishiguro, H., Haruki, N., Sugiura, H., Tanaka, T., Kimura, M., Shinoda, N., Kuwabara, Y., Fujii, Y."Excision repair cross complementing 3 expression is involved in patient prognosis and tumor progression in esophageal cancer". Oncology Reports 12, no. 4 (2004): 827-831. https://doi.org/10.3892/or.12.4.827
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