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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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December 2004 Volume 12 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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December 2004 Volume 12 Issue 6

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Article

Amplicon profiling reveals cytoplasmic overexpression of MUC1 protein as an indicator of resistance to platinum-based chemotherapy in patients with ovarian cancer

  • Authors:
    • Masashi Takano
    • Kazuyuki Fujii
    • Tsunekazu Kita
    • Yoshihiro Kikuchi
    • Kazuhiko Uchida

  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, National Defense Medical College, Saitama 359-8513, Japan. mastkn@me.ndmc.ac.jp
  • Pages: 1177-1182
    |
    Published online on: December 1, 2004
       https://doi.org/10.3892/or.12.6.1177
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Abstract

Chromosomal gains of 1q21-q22 and 13q12-q14 were closely related with the chemoresistance of patients with ovarian cancer in our previous CGH (comparative genomic hybridization) study. We conducted the present study to determine the amplified genes on chromosome 1q. Comparisons of relative copy numbers of clinically platinum-sensitive ovarian tumors (CR-group, n=14) and platinum-resistant tumors (PD-group, n=14) were carried out using real-time PCR from ten different gene loci on chromosome 1q. Increased copy numbers were frequently observed in PD-group tumors, especially in the region between WI-8123 and MUC1. Relative copy number of MUC1 over 1.5 was observed in 13 (92%) of 14 PD-group tumors and 3 (21%) of 14 CR-group tumors (p<0.05). Moreover, cytoplasmic expressions of MUC1 protein were significantly higher in PD-group than those in CR-group (p<0.01). We concluded that the cytoplasmic overexpression of MUC1 might be an indicator of resistance to platinum-based chemotherapy and a prognostic marker in ovarian cancer.

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Copy and paste a formatted citation
Spandidos Publications style
Takano M, Fujii K, Kita T, Kikuchi Y and Uchida K: Amplicon profiling reveals cytoplasmic overexpression of MUC1 protein as an indicator of resistance to platinum-based chemotherapy in patients with ovarian cancer. Oncol Rep 12: 1177-1182, 2004.
APA
Takano, M., Fujii, K., Kita, T., Kikuchi, Y., & Uchida, K. (2004). Amplicon profiling reveals cytoplasmic overexpression of MUC1 protein as an indicator of resistance to platinum-based chemotherapy in patients with ovarian cancer. Oncology Reports, 12, 1177-1182. https://doi.org/10.3892/or.12.6.1177
MLA
Takano, M., Fujii, K., Kita, T., Kikuchi, Y., Uchida, K."Amplicon profiling reveals cytoplasmic overexpression of MUC1 protein as an indicator of resistance to platinum-based chemotherapy in patients with ovarian cancer". Oncology Reports 12.6 (2004): 1177-1182.
Chicago
Takano, M., Fujii, K., Kita, T., Kikuchi, Y., Uchida, K."Amplicon profiling reveals cytoplasmic overexpression of MUC1 protein as an indicator of resistance to platinum-based chemotherapy in patients with ovarian cancer". Oncology Reports 12, no. 6 (2004): 1177-1182. https://doi.org/10.3892/or.12.6.1177
Copy and paste a formatted citation
x
Spandidos Publications style
Takano M, Fujii K, Kita T, Kikuchi Y and Uchida K: Amplicon profiling reveals cytoplasmic overexpression of MUC1 protein as an indicator of resistance to platinum-based chemotherapy in patients with ovarian cancer. Oncol Rep 12: 1177-1182, 2004.
APA
Takano, M., Fujii, K., Kita, T., Kikuchi, Y., & Uchida, K. (2004). Amplicon profiling reveals cytoplasmic overexpression of MUC1 protein as an indicator of resistance to platinum-based chemotherapy in patients with ovarian cancer. Oncology Reports, 12, 1177-1182. https://doi.org/10.3892/or.12.6.1177
MLA
Takano, M., Fujii, K., Kita, T., Kikuchi, Y., Uchida, K."Amplicon profiling reveals cytoplasmic overexpression of MUC1 protein as an indicator of resistance to platinum-based chemotherapy in patients with ovarian cancer". Oncology Reports 12.6 (2004): 1177-1182.
Chicago
Takano, M., Fujii, K., Kita, T., Kikuchi, Y., Uchida, K."Amplicon profiling reveals cytoplasmic overexpression of MUC1 protein as an indicator of resistance to platinum-based chemotherapy in patients with ovarian cancer". Oncology Reports 12, no. 6 (2004): 1177-1182. https://doi.org/10.3892/or.12.6.1177
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