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Print ISSN: 1021-335X Online ISSN: 1791-2431
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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
December 2004 Volume 12 Issue 6

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Journal Metrics

Impact Factor: 3.9

CiteScore: 8.3

CiteScore Rank: Q1: #73/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Article

Plasminogen activator inhibitor type-1 mutants regulate angiogenesis of human umbilical and lung vascular endothelial cells

Joanna Chorostowska-Wynimko, Rafal Swiercz, Ewa Skrzypczak-Jankun, Steven H. Selman, Jerzy Jankun
Pages: 1155-1162
Published online on: 01 December 2004

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Article

Relationship between immunohistochemical evaluation of thymidylate synthase and proliferating cell nuclear antigen labeling index in gastrointestinal carcinoma

Yukihiro Kunimoto, Takeshi Nakamura, Masakazu Ohno, Yoshikazu Kuroda
Pages: 1163-1167
Published online on: 01 December 2004

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Article

Suppressive effect of CPT-11 on rat esophageal tumorigenesis induced by N-nitrosomethylbenzylamine

Yushi Fukiwara, Harushi Osugi, Keichirou Morimura, Masashi Takemura, Shigeru Lee, Kazuhiro Hirohashi, Shoji Fukushima, Shigefumi Suehiro
Pages: 1169-1176
Published online on: 01 December 2004

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Article

Amplicon profiling reveals cytoplasmic overexpression of MUC1 protein as an indicator of resistance to platinum-based chemotherapy in patients with ovarian cancer

Masashi Takano, Kazuyuki Fujii, Tsunekazu Kita, Yoshihiro Kikuchi, Kazuhiko Uchida
Pages: 1177-1182
Published online on: 01 December 2004

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Article

Induction of apoptosis by maackiain and trifolirhizin (maackiain glycoside) isolated from sanzukon (Sophora Subprostrate Chen et T. Chen) in human promyelotic leukemia HL-60 cells

Yue Aratanechemuge, Hiroshige Hibasami, Hirotaka Katsuzaki, Kunio Imai, Takashi Komiya
Pages: 1183-1188
Published online on: 01 December 2004

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Article

Expression of survivin mRNA associates with apoptosis, proliferation and histologically aggressive features in hepatocellular carcinoma

Soichiro Morinaga, Yoshiyasu Nakamura, Naoki Ishiwa, Takaki Yoshikawa, Yoshikazu Noguchi, Yuji Yamamoto, Yasushi Rino, Toshio Imada, Yoshinori Takanashi, Makoto Akaike, Yukio Sugimasa, Shoji Takemiya
Pages: 1189-1194
Published online on: 01 December 2004

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Article

Intrinsic radiosensitivity by metallothionein expression has no great influence on clinical radiosensitivity in esophageal carcinoma

Takuma Nomiya, Kenji Nemoto, Eiko Nakata, Hideo Miyachi, Yoshihiro Takai, Shogo Yamada
Pages: 1195-1199
Published online on: 01 December 2004

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Article

P-glycoprotein 170 expression and function as an adverse independent prognostic factor in childhood acute lymphoblastic leukemia

F. Casale, V. D'Angelo, R. Addeo, M. Caraglia, S. Crisci, R. Rondelli, M. T. Di Tullio, P. Indolfi
Pages: 1201-1207
Published online on: 01 December 2004

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Article

Nitric oxide production in fluoro-edenite treated mouse monocyte-macrophage cultures

Venera Cardile, Lidia Proietti, Annamaria Panico, Laura Lombardo
Pages: 1209-1215
Published online on: 01 December 2004

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Article

The role of hMSH3 and hMSH6 in ovarian endometrioid carcinoma and relationship with microsatellite instability phenotype

Constance T. Albarracin, Elvio G. Silva, Anais Malpica, Rajalakshmi Luthra, Jinsong Liu
Pages: 1217-1219
Published online on: 01 December 2004

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Article

Assessment of K-ras, Smad4 and p53 gene alterations in colorectal metastases and their role in the metastatic process

Lorena Losi, Gabriele Luppi, Jean Benhattar
Pages: 1221-1225
Published online on: 01 December 2004

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Article

Demonstration of human telomerase reverse transcriptase by in situ hybridization in lung carcinoma

Mitsuhiro Fukushima, Naotaka Shimomura, Ken-Ichi Nakamura, Makoto Kammori, Kiyoshi Koizumi, Kazuo Shimizu, Kaiyo Takubo
Pages: 1227-1232
Published online on: 01 December 2004

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Article

Methyl jasmonate induces apoptosis through induction of Bax/Bcl-Xs and activation of caspase-3 via ROS production in A549 cells

Ji Hye Kim, Su Yeon Lee, Su Young Oh, Song Iy Han, Hye Gyeong Park, Mi-Ae Yoo, Ho Sung Kang
Pages: 1233-1238
Published online on: 01 December 2004

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Article

Cdx2 expression in pancreatic tumors: Relationship with prognosis of invasive ductal carcinomas

Kakuya Matsumoto, Tsutomu Mizoshita, Tetsuya Tsukamoto, Naotaka Ogasawara, Akihiro Hirata, Yasuhiro Shimizu, Masakazu Haneda, Kenji Yamao, Masae Tatematsu
Pages: 1239-1243
Published online on: 01 December 2004

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Article

mRNA and protein expression of PUMA in sporadic colorectal cancer

Agneta Jansson, Gunnar Arbman, Xiao-Feng Sun
Pages: 1245-1249
Published online on: 01 December 2004

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Article

Characterization of stage-specific embryonic antigen-1 expression during early stages of human embryogenesis

Shanrong Liu, Houqi Liu, Shuping Tang, Yuqiong Pan, Kaihong Ji, Hui Ning, Shuling Wang, Zhongtian Qi, Lingsong Li
Pages: 1251-1256
Published online on: 01 December 2004

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Article

Utility of initial MRI for predicting extent of residual disease after neoadjuvant chemotherapy: Analysis of 70 breast cancer patients

Yoriko Murata, Yasuhiro Ogawa, Shoji Yoshida, Kei Kubota, Satoshi Itoh, Mitsutaka Fukumoto, Akihito Nishioka, Toshiaki Moriki, Hironori Maeda, Yosuke Tanaka
Pages: 1257-1262
Published online on: 01 December 2004

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Article

TU12B1-TY, a novel gene in the region at 12q22-q23.1 frequently deleted in pancreatic cancer, shows reduced expression in pancreatic cancer cells

Toshimasa Yatsuoka, Toru Furukawa, Makoto Sunamura, Seiki Matsuno, Akira Horii
Pages: 1263-1268
Published online on: 01 December 2004

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Article

Hotspot mutations of BRAF gene are not associated with pediatric solid neoplasms

Jiangyong Miao, Takeshi Kusafuka, Masahiro Fukuzawa
Pages: 1269-1272
Published online on: 01 December 2004

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Article

Loss of imprinting of PEG1/MEST in lung cancer cell lines

Hirofumi Nakanishi, Tetsuji Suda, Motonobu Katoh, Akiko Watanabe, Tadashi Igishi, Masahiro Kodani, Shingo Matsumoto, Masaki Nakamoto, Yasushi Shigeoka, Tetsuro Okabe, Mitsuo Oshimura, Eiji Shimizu
Pages: 1273-1278
Published online on: 01 December 2004

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Article

Effects of thymidine phosphorylase levels in cancer, background mucosa, and regional lymph nodes on survival of advanced gastric cancer patients receiving postoperative fluoropyrimidine therapy

Takeo Kosaka, Kazuo Usami, Nobuo Ueshige, Junichi Sugaya, Yasuharu Nakano, Shigeki Takashima
Pages: 1279-1286
Published online on: 01 December 2004

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Article

Gene expression in response to anti-tumour intervention by polysaccharide-K (PSK) in colorectal carcinoma cells

Reigetsu Yoshikawa, Hidenori Yanagi, Tomoko Hashimoto-Tamaoki, Tomonori Morinaga, Yoshiro Nakano, Masafumi Noda, Yoshinori Fujiwara, Haruki Okamura, Takehira Yamamura
Pages: 1287-1293
Published online on: 01 December 2004

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Article

Long-term survival of patients with advanced colorectal cancer may not be due to the response to chemotherapy

George P. Stathopoulos, Sotiris K. Rigatos, Nicos A. Malamos, John G. Stathopoulos, Panayiota Thallasinou, Ekaterini Papazachariou, Fotini Antoniou, Emmanuel Kondopodis, John Xynotroulas
Pages: 1295-1300
Published online on: 01 December 2004

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Article

Predicting recurrence and metastasis of stage III/Dukes' C colorectal cancer with lymph node metastasis

Masaya Mukai, Shinkichi Sato, Tomomi Kimura, Hiromi Ninomiya, Nobukazu Komatsu, Takayuki Tajima, Hisao Nakasaki, Hiroyasu Makuuchi
Pages: 1301-1304
Published online on: 01 December 2004

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Article

Predicting recurrence and metastasis of Dukes' A primary colorectal cancer with or without proper muscle invasion

Masaya Mukai, Shinkichi Sato, Hiromi Ninomiya, Tomomi Kimura, Nobukazu Komatsu, Takayuki Tajima, Hisao Nakasaki, Hiroyasu Makuuchi
Pages: 1305-1308
Published online on: 01 December 2004

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Article

ErbB2 oncogene antibodies differentiate between the normal and diseased pancreas, and between chronic pancreatitis and pancreatic cancer

Jens Standop, Matthias Schneider, Alexis Ulrich, Guenther Mathiak, Randall E. Brand, Markus W. Buechler, Parviz M. Pour
Pages: 1309-1315
Published online on: 01 December 2004

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Article

Immunohistochemical staining of metallothionein in canine mammary tumors: better survival with higher expression

Sérgio Vitorino Cardoso, Marcelo Vidigal Caliari, Maria Cássia Ferreira de Aguiar, Geovanni Dantas Cassali
Pages: 1317-1321
Published online on: 01 December 2004

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Article

Inactivation of HTB63 human melanoma cells by irradiation with protons and gamma rays

Aleksandra Ristic-Fira, Ivan Petrovic, Danijela Todorovic, Lela Koricanac, Miroslava Vujèic, Miroslav Demajo, Gabriella Sabini, Pablo Cirrone, Giacomo Cuttone
Pages: 1323-1328
Published online on: 01 December 2004

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Article

Response of T and B lymphocytes in the spleen, lymph nodes and mammary tumors in rats treated with human soluble tumor-associated antigens and commercial human albumin

Herzl Ben-Hur, George Kossoy, Herbert Mehrdad, Asher Elhayany, Itshak Zusman
Pages: 1329-1333
Published online on: 01 December 2004

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Article

Frequent CYP1A1 expression in gastric cancers and their related lesions

Kai-Li Zhang, Jing-Xin Ma, Xiao-Yan Chen, Yuan Sun, Qing-You Kong, Jia Liu, Hong Li
Pages: 1335-1340
Published online on: 01 December 2004

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Article

PTEN and DMBT1 homozygous deletion and expression in medulloblastomas and supratentorial primitive neuroectodermal tumors

María Del Mar Inda, Javier Mercapide, Jorge Muñoz, Philippe Coullin, Giséle Danglot, Teresa Tuñon, José María Martínez-Peñuela, José María Rivera, Juan J. Burgos, Alain Bernheim, Javier S. Castresana
Pages: 1341-1347
Published online on: 01 December 2004

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Article

The role of Raf-1 in radiation resistance of human hepatocellular carcinoma Hep G2 cells

W. Y. Tang, Sophia P.Y. Chau, W. P. Tsang, S. K. Kong, T. T. Kwok
Pages: 1349-1354
Published online on: 01 December 2004

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Article

Expression levels of melanoma inhibitory activity correlate with time to progression in patients with high-grade glioma

Peter Hau, Petra Ruemmele, Leoni A. Kunz-Schughart, Anett Doerfelt, Birgit Hirschmann, Annette Lohmeier, Horst Koch, Adolf Mueller, Ulrich Bogdahn, Anja-Katrin Bosserhoff
Pages: 1355-1364
Published online on: 01 December 2004

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Article

Effect of lung resistance-related protein on the resistance to cisplatin in human ovarian cancer cell lines

Wei Wang, Shunan Ke, Gang Chen, Qinglei Gao, Sufang Wu, Shixuan Wang, Jianfeng Zhou, Xiaokui Yang, Yunping Lu, Ding Ma
Pages: 1365-1370
Published online on: 01 December 2004

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Article

Lovastatin potentiates antitumor effects of saquinavir against human lymphoma cells

Tadeusz Issat, Dominika Nowis, Marek Jakóbisiak, Jakub Golab
Pages: 1371-1375
Published online on: 01 December 2004

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Journal Cover
May-2026 Volume 55 Issue 5

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Journal Metrics

Impact Factor: 3.9

CiteScore: 8.3

CiteScore Rank: Q1: #73/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Article Open Access

ZBTB7A promotes malignant phenotypes in ovarian cancer through transcriptional activation of CRLF1

Xiaobai Hao, Yu Chen
Article Number: 102
Published online on: 24 March 2026

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Article Open Access

MS4322 is a selective protein arginine methyltransferase 5 degrader with antitumor effects in cervical cancer cells

Rui Luo, Jingping Chen, Zhaojie Chen, Surong Wang, Tianfeng Liu, Yang Xu
Article Number: 101
Published online on: 24 March 2026

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Retraction Open Access

[Retracted] Roles of the SNHG7/microRNA‑9‑5p/DPP4 ceRNA network in the growth and 131I resistance of thyroid carcinoma cells through PI3K/Akt activation

Wanzhi Chen, Jichun Yu, Rong Xie, Tao Zhou, Chengfeng Xiong, Shuyong Zhang, Meijun Zhong
Article Number: 100
Published online on: 23 March 2026

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Article Open Access

Andrographis exerts antitumor effects and enhances 5‑FU efficacy via the alteration of ferroptosis‑related genes in esophageal squamous cell carcinoma

Kosuke Yoshimura, Tadanobu Shimura, Ruiya Ma, Yaxuan Huang, Takahito Kitajima, Shinji Yamashita, Yuki Sato, Koki Higashi, Mikio Kawamura, Hiromi Yasuda, Yuhki Koike, Yoshiki Okita, Shigeyuki Yoshiyama, Minako Kobayashi, Masaki Ohi, Hiroki Ohge, Shinya Takahashi, Ajay Goel, Yoshinaga Okugawa, Yuji Toiyama
Article Number: 99
Published online on: 20 March 2026

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Article Open Access

Sphingosine‑1‑phosphate receptor 1 enhances olfactory receptor 51E1‑mediated inhibition of proliferation via Src/JNK signaling in prostate cancer cells

Kiheon Kim, Jinwoo Lee, Chulwon Choi, Jungnam Bae, Hee-Jung Choi, Won-Ki Huh
Article Number: 98
Published online on: 19 March 2026

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Review Open Access

Mechanistic insights into the roles of astragalosides and Astragalus polysaccharides in gynecological and breast cancers (Review)

Ruixin Liu, Zhanyu Lin, Yuelin Li, Yuetong Ci, Zhengqi Guo, Zhenguo Xu
Article Number: 97
Published online on: 19 March 2026

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Retraction Open Access

[Retracted] Inhibition of tankyrase 1 in human gastric cancer cells enhances telomere shortening by telomerase inhibitors 

Hao Zhang, Meng-Hua Yang, Jing-Jing Zhao, Ling Chen, Song-Tao Yu, Xu-Dong Tang, Dian-Chun Fang, Shi-Ming Yang
Article Number: 96
Published online on: 16 March 2026

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Article Open Access

Silencing of SIVA‑1 promotes cisplatin resistance in gastric cancer via the Bcl‑2/BAX‑mediated mitochondria‑dependent apoptosis pathway

Zheng-Yi Shi, Zheng-Rong Ding, Yu-Liang Huang, Yuan-Rui Lei, Hai-Bin Huang, Yan Qing, Miao-Ren Deng, Xu-Man Lu, Xu-Dong Dong, Long-Jie Xia, Sheng Xu, Xiao-Gang Zhong, Lei Li, Fan-Biao Kong, Xiao-Tong Wang
Article Number: 95
Published online on: 13 March 2026

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Article Open Access

Depleting HIF‑1α attenuates the progression of osteosarcoma, but tumorigenicity is sustained through HIF‑independent pathways

Ayaka Kunishima, Takatsune Shimizu, Tetsuya Takimoto, Atsunobu Sagara, Hiroyuki Nobusue, Hidetoshi Hasuwa, Shinya Hasegawa, Yuka Tamaoki, Hitomi Miyake, Yumi Fukuchi, Hideyuki Saya, Akihiro Muto
Article Number: 94
Published online on: 12 March 2026

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Article Open Access

Unveiling the role of ANGPT2 in esophageal cancer: A prognostic factor and potential oncogene

Zhigang Zhai, Zhenyu Xue, Yuan Fang, Yixu Fan, Shijiao Li, Yunpeng Yu, Chuansheng Chen, Kaijun Zhang, Deyu Chen, Xiang Tang, Rui Ling
Article Number: 93
Published online on: 12 March 2026

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Article Open Access

POLQ promotes tumor progression and immunosuppression via ATM‑P53 signaling in endometrial cancer

Ningning Zhu, Juanjuan Wang, Xiaoli Zhang, Kai Tang, Lei Gong, Yi Hu
Article Number: 92
Published online on: 11 March 2026

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Correction Open Access

[Corrigendum] 3‑Bromopyruvate and sodium citrate target glycolysis, suppress survivin, and induce mitochondrial‑mediated apoptosis in gastric cancer cells and inhibit gastric orthotopic transplantation tumor growth

Ting-An Wang, Xiao-Dong Zhang, Xing-Yu Guo, Shu-Lin Xian, Yun-Fei Lu
Article Number: 91
Published online on: 11 March 2026

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Review Open Access

Unveiling the molecular landscape: Long non-coding RNAs in neuroblastoma (Review)

Zidong Xia, Huishan Zhai, Lei Zheng, Cheng Wang
Article Number: 90
Published online on: 09 March 2026

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Retraction Open Access

[Retracted] Erastin sensitizes glioblastoma cells to temozolomide by restraining xCT and cystathionine‑γ‑lyase function

Liangyu Chen, Xinxing Li, Libo Liu, Bo Yu, Yixue Xue, Yunhui Liu
Article Number: 89
Published online on: 09 March 2026

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Review Open Access

Advances in the application of frailty scoring in the diagnosis and management of elderly patients with multiple myeloma (Review)

Junlun Liu, Danyu Li, Chao Li, Zhuoren Chen
Article Number: 88
Published online on: 06 March 2026

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Expression of Concern Open Access

[Expression of Concern] c‑Fos/ERK promotes the progression from pancreatic intraepithelial neoplasia to pancreatic ductal adenocarcinoma 

Lei You, Xiaoxia Ren, Yongxing Du, Wenjing Zhao, Ming Cui, Ge Chen, Yupei Zhao
Article Number: 87
Published online on: 05 March 2026

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Review Open Access

CXCL1 in triple‑negative breast cancer: Mechanisms, challenges, and therapeutic opportunities (Review)

Hiba Al Sayegh, Zahraa Assi, Amjad Kanaan, Mirvat El Sibai
Article Number: 86
Published online on: 03 March 2026

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Article Open Access

Cellular and inflammatory characteristics of patient‑derived glioblastoma organoids during in vitro cultivation

Jessica Nojszewski, Nils Oliver Schröder, Jacqueline Clüver, Jonna Holler, Hajrullah Ahmeti, Michael Synowitz, Janka Held-Feindt
Article Number: 85
Published online on: 02 March 2026

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Retraction Open Access

[Retracted] Growth and differentiation factor‑9 promotes adhesive and motile capacity of prostate cancer cells by up‑regulating FAK and Paxillin via Smad dependent pathway 

Sivan M. Bokobza, Lin Ye, Howard G. Kynaston, Wen G. Jiang
Article Number: 84
Published online on: 02 March 2026

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Article Open Access

Platycodin D sensitizes head and neck squamous cell carcinoma to cisplatin by inducing autophagy arrest

Minji Bae, Min Kyeong Lee, Mi Gyeong Jeong, Yeonseo Lee, Harim Joo, Young Chan Lee, Jung Woo Lee, Su Il Kim, Seong-Gyu Ko, Young-Gyu Eun
Article Number: 83
Published online on: 27 February 2026

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Article Open Access

ACSBG1‑driven lipid reprogramming unveiled: A fatty acid metabolism‑associated prognostic model for lung adenocarcinoma

Panxin Hu, Anan Li
Article Number: 82
Published online on: 27 February 2026

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Article Open Access

Knockdown of CCT2 inhibits the malignant progression of hepatocellular carcinoma cells by impairing STAT3 activation

Chao Li, Lei Yang, Yudong Zhang, Baocheng Zhao, Hao Qu
Article Number: 81
Published online on: 25 February 2026

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Retraction Open Access

[Retracted] Songorine suppresses cell growth and metastasis in epithelial ovarian cancer via the Bcl‑2/Bax and GSK3β/β‑catenin signaling pathways

Hongxia Zhang, Ruifeng Dong, Ping Zhang, Yankui Wang
Article Number: 80
Published online on: 25 February 2026

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Journal Cover
June-2026 Volume 55 Issue 6

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Journal Metrics

Impact Factor: 3.9

CiteScore: 8.3

CiteScore Rank: Q1: #73/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Review Open Access

Role of CHD4 in tumor progression, DNA damage response and treatment resistance (Review)

Shuo Li, Quan Ma, Keying Lian, Zhisheng Jiang, Yun Ma
Article Number: 107
Published online on: 02 April 2026

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Review Open Access

T cell fate regulation in EBV‑associated nasopharyngeal carcinoma (Review)

Liuyang Zhang, Shun Ding, Dongzhui Chen, Benchi Cai, Zhonglin Mu
Article Number: 106
Published online on: 02 April 2026

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Retraction Open Access

[Retracted] Ultrasound‑targeted microbubble destruction‑mediated overexpression of Sirtuin 3 inhibits the progression of ovarian cancer

Li Cheng, Dongmei Zhang, Wei Yan
Article Number: 105
Published online on: 02 April 2026

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Review Open Access

HMGB3: A pivotal orchestrator of therapy resistance and cancer stemness in human malignancies (Review)

Ju Zhang, Yifan Sun, Lanyu Wang, Jiayu Gu, Ye Hua, Jianfeng Shao, Ninghan Feng
Article Number: 104
Published online on: 01 April 2026

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Expression of Concern Open Access

[Expression of Concern] 5‑Azacytidine inhibits the proliferation of bladder cancer cells via reversal of the aberrant hypermethylation of the hepaCAM gene

Xiaorong Wang, E. Chen, Xue Yang, Yin Wang, Zhen Quan, Xiaohou Wu, Chunli Luo
Article Number: 103
Published online on: 30 March 2026

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