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Print ISSN: 1021-335X Online ISSN: 1791-2431
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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
December 2004 Volume 12 Issue 6

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Journal Metrics

Impact Factor: 3.9

CiteScore: 8.3

CiteScore Rank: Q1: #73/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Article

Plasminogen activator inhibitor type-1 mutants regulate angiogenesis of human umbilical and lung vascular endothelial cells

Joanna Chorostowska-Wynimko, Rafal Swiercz, Ewa Skrzypczak-Jankun, Steven H. Selman, Jerzy Jankun
Pages: 1155-1162
Published online on: 01 December 2004

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Article

Relationship between immunohistochemical evaluation of thymidylate synthase and proliferating cell nuclear antigen labeling index in gastrointestinal carcinoma

Yukihiro Kunimoto, Takeshi Nakamura, Masakazu Ohno, Yoshikazu Kuroda
Pages: 1163-1167
Published online on: 01 December 2004

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Article

Suppressive effect of CPT-11 on rat esophageal tumorigenesis induced by N-nitrosomethylbenzylamine

Yushi Fukiwara, Harushi Osugi, Keichirou Morimura, Masashi Takemura, Shigeru Lee, Kazuhiro Hirohashi, Shoji Fukushima, Shigefumi Suehiro
Pages: 1169-1176
Published online on: 01 December 2004

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Article

Amplicon profiling reveals cytoplasmic overexpression of MUC1 protein as an indicator of resistance to platinum-based chemotherapy in patients with ovarian cancer

Masashi Takano, Kazuyuki Fujii, Tsunekazu Kita, Yoshihiro Kikuchi, Kazuhiko Uchida
Pages: 1177-1182
Published online on: 01 December 2004

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Article

Induction of apoptosis by maackiain and trifolirhizin (maackiain glycoside) isolated from sanzukon (Sophora Subprostrate Chen et T. Chen) in human promyelotic leukemia HL-60 cells

Yue Aratanechemuge, Hiroshige Hibasami, Hirotaka Katsuzaki, Kunio Imai, Takashi Komiya
Pages: 1183-1188
Published online on: 01 December 2004

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Article

Expression of survivin mRNA associates with apoptosis, proliferation and histologically aggressive features in hepatocellular carcinoma

Soichiro Morinaga, Yoshiyasu Nakamura, Naoki Ishiwa, Takaki Yoshikawa, Yoshikazu Noguchi, Yuji Yamamoto, Yasushi Rino, Toshio Imada, Yoshinori Takanashi, Makoto Akaike, Yukio Sugimasa, Shoji Takemiya
Pages: 1189-1194
Published online on: 01 December 2004

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Article

Intrinsic radiosensitivity by metallothionein expression has no great influence on clinical radiosensitivity in esophageal carcinoma

Takuma Nomiya, Kenji Nemoto, Eiko Nakata, Hideo Miyachi, Yoshihiro Takai, Shogo Yamada
Pages: 1195-1199
Published online on: 01 December 2004

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Article

P-glycoprotein 170 expression and function as an adverse independent prognostic factor in childhood acute lymphoblastic leukemia

F. Casale, V. D'Angelo, R. Addeo, M. Caraglia, S. Crisci, R. Rondelli, M. T. Di Tullio, P. Indolfi
Pages: 1201-1207
Published online on: 01 December 2004

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Article

Nitric oxide production in fluoro-edenite treated mouse monocyte-macrophage cultures

Venera Cardile, Lidia Proietti, Annamaria Panico, Laura Lombardo
Pages: 1209-1215
Published online on: 01 December 2004

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Article

The role of hMSH3 and hMSH6 in ovarian endometrioid carcinoma and relationship with microsatellite instability phenotype

Constance T. Albarracin, Elvio G. Silva, Anais Malpica, Rajalakshmi Luthra, Jinsong Liu
Pages: 1217-1219
Published online on: 01 December 2004

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Article

Assessment of K-ras, Smad4 and p53 gene alterations in colorectal metastases and their role in the metastatic process

Lorena Losi, Gabriele Luppi, Jean Benhattar
Pages: 1221-1225
Published online on: 01 December 2004

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Article

Demonstration of human telomerase reverse transcriptase by in situ hybridization in lung carcinoma

Mitsuhiro Fukushima, Naotaka Shimomura, Ken-Ichi Nakamura, Makoto Kammori, Kiyoshi Koizumi, Kazuo Shimizu, Kaiyo Takubo
Pages: 1227-1232
Published online on: 01 December 2004

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Article

Methyl jasmonate induces apoptosis through induction of Bax/Bcl-Xs and activation of caspase-3 via ROS production in A549 cells

Ji Hye Kim, Su Yeon Lee, Su Young Oh, Song Iy Han, Hye Gyeong Park, Mi-Ae Yoo, Ho Sung Kang
Pages: 1233-1238
Published online on: 01 December 2004

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Article

Cdx2 expression in pancreatic tumors: Relationship with prognosis of invasive ductal carcinomas

Kakuya Matsumoto, Tsutomu Mizoshita, Tetsuya Tsukamoto, Naotaka Ogasawara, Akihiro Hirata, Yasuhiro Shimizu, Masakazu Haneda, Kenji Yamao, Masae Tatematsu
Pages: 1239-1243
Published online on: 01 December 2004

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Article

mRNA and protein expression of PUMA in sporadic colorectal cancer

Agneta Jansson, Gunnar Arbman, Xiao-Feng Sun
Pages: 1245-1249
Published online on: 01 December 2004

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Article

Characterization of stage-specific embryonic antigen-1 expression during early stages of human embryogenesis

Shanrong Liu, Houqi Liu, Shuping Tang, Yuqiong Pan, Kaihong Ji, Hui Ning, Shuling Wang, Zhongtian Qi, Lingsong Li
Pages: 1251-1256
Published online on: 01 December 2004

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Article

Utility of initial MRI for predicting extent of residual disease after neoadjuvant chemotherapy: Analysis of 70 breast cancer patients

Yoriko Murata, Yasuhiro Ogawa, Shoji Yoshida, Kei Kubota, Satoshi Itoh, Mitsutaka Fukumoto, Akihito Nishioka, Toshiaki Moriki, Hironori Maeda, Yosuke Tanaka
Pages: 1257-1262
Published online on: 01 December 2004

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Article

TU12B1-TY, a novel gene in the region at 12q22-q23.1 frequently deleted in pancreatic cancer, shows reduced expression in pancreatic cancer cells

Toshimasa Yatsuoka, Toru Furukawa, Makoto Sunamura, Seiki Matsuno, Akira Horii
Pages: 1263-1268
Published online on: 01 December 2004

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Article

Hotspot mutations of BRAF gene are not associated with pediatric solid neoplasms

Jiangyong Miao, Takeshi Kusafuka, Masahiro Fukuzawa
Pages: 1269-1272
Published online on: 01 December 2004

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Article

Loss of imprinting of PEG1/MEST in lung cancer cell lines

Hirofumi Nakanishi, Tetsuji Suda, Motonobu Katoh, Akiko Watanabe, Tadashi Igishi, Masahiro Kodani, Shingo Matsumoto, Masaki Nakamoto, Yasushi Shigeoka, Tetsuro Okabe, Mitsuo Oshimura, Eiji Shimizu
Pages: 1273-1278
Published online on: 01 December 2004

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Article

Effects of thymidine phosphorylase levels in cancer, background mucosa, and regional lymph nodes on survival of advanced gastric cancer patients receiving postoperative fluoropyrimidine therapy

Takeo Kosaka, Kazuo Usami, Nobuo Ueshige, Junichi Sugaya, Yasuharu Nakano, Shigeki Takashima
Pages: 1279-1286
Published online on: 01 December 2004

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Article

Gene expression in response to anti-tumour intervention by polysaccharide-K (PSK) in colorectal carcinoma cells

Reigetsu Yoshikawa, Hidenori Yanagi, Tomoko Hashimoto-Tamaoki, Tomonori Morinaga, Yoshiro Nakano, Masafumi Noda, Yoshinori Fujiwara, Haruki Okamura, Takehira Yamamura
Pages: 1287-1293
Published online on: 01 December 2004

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Article

Long-term survival of patients with advanced colorectal cancer may not be due to the response to chemotherapy

George P. Stathopoulos, Sotiris K. Rigatos, Nicos A. Malamos, John G. Stathopoulos, Panayiota Thallasinou, Ekaterini Papazachariou, Fotini Antoniou, Emmanuel Kondopodis, John Xynotroulas
Pages: 1295-1300
Published online on: 01 December 2004

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Article

Predicting recurrence and metastasis of stage III/Dukes' C colorectal cancer with lymph node metastasis

Masaya Mukai, Shinkichi Sato, Tomomi Kimura, Hiromi Ninomiya, Nobukazu Komatsu, Takayuki Tajima, Hisao Nakasaki, Hiroyasu Makuuchi
Pages: 1301-1304
Published online on: 01 December 2004

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Article

Predicting recurrence and metastasis of Dukes' A primary colorectal cancer with or without proper muscle invasion

Masaya Mukai, Shinkichi Sato, Hiromi Ninomiya, Tomomi Kimura, Nobukazu Komatsu, Takayuki Tajima, Hisao Nakasaki, Hiroyasu Makuuchi
Pages: 1305-1308
Published online on: 01 December 2004

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Article

ErbB2 oncogene antibodies differentiate between the normal and diseased pancreas, and between chronic pancreatitis and pancreatic cancer

Jens Standop, Matthias Schneider, Alexis Ulrich, Guenther Mathiak, Randall E. Brand, Markus W. Buechler, Parviz M. Pour
Pages: 1309-1315
Published online on: 01 December 2004

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Article

Immunohistochemical staining of metallothionein in canine mammary tumors: better survival with higher expression

Sérgio Vitorino Cardoso, Marcelo Vidigal Caliari, Maria Cássia Ferreira de Aguiar, Geovanni Dantas Cassali
Pages: 1317-1321
Published online on: 01 December 2004

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Article

Inactivation of HTB63 human melanoma cells by irradiation with protons and gamma rays

Aleksandra Ristic-Fira, Ivan Petrovic, Danijela Todorovic, Lela Koricanac, Miroslava Vujèic, Miroslav Demajo, Gabriella Sabini, Pablo Cirrone, Giacomo Cuttone
Pages: 1323-1328
Published online on: 01 December 2004

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Article

Response of T and B lymphocytes in the spleen, lymph nodes and mammary tumors in rats treated with human soluble tumor-associated antigens and commercial human albumin

Herzl Ben-Hur, George Kossoy, Herbert Mehrdad, Asher Elhayany, Itshak Zusman
Pages: 1329-1333
Published online on: 01 December 2004

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Article

Frequent CYP1A1 expression in gastric cancers and their related lesions

Kai-Li Zhang, Jing-Xin Ma, Xiao-Yan Chen, Yuan Sun, Qing-You Kong, Jia Liu, Hong Li
Pages: 1335-1340
Published online on: 01 December 2004

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Article

PTEN and DMBT1 homozygous deletion and expression in medulloblastomas and supratentorial primitive neuroectodermal tumors

María Del Mar Inda, Javier Mercapide, Jorge Muñoz, Philippe Coullin, Giséle Danglot, Teresa Tuñon, José María Martínez-Peñuela, José María Rivera, Juan J. Burgos, Alain Bernheim, Javier S. Castresana
Pages: 1341-1347
Published online on: 01 December 2004

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Article

The role of Raf-1 in radiation resistance of human hepatocellular carcinoma Hep G2 cells

W. Y. Tang, Sophia P.Y. Chau, W. P. Tsang, S. K. Kong, T. T. Kwok
Pages: 1349-1354
Published online on: 01 December 2004

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Article

Expression levels of melanoma inhibitory activity correlate with time to progression in patients with high-grade glioma

Peter Hau, Petra Ruemmele, Leoni A. Kunz-Schughart, Anett Doerfelt, Birgit Hirschmann, Annette Lohmeier, Horst Koch, Adolf Mueller, Ulrich Bogdahn, Anja-Katrin Bosserhoff
Pages: 1355-1364
Published online on: 01 December 2004

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Article

Effect of lung resistance-related protein on the resistance to cisplatin in human ovarian cancer cell lines

Wei Wang, Shunan Ke, Gang Chen, Qinglei Gao, Sufang Wu, Shixuan Wang, Jianfeng Zhou, Xiaokui Yang, Yunping Lu, Ding Ma
Pages: 1365-1370
Published online on: 01 December 2004

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Article

Lovastatin potentiates antitumor effects of saquinavir against human lymphoma cells

Tadeusz Issat, Dominika Nowis, Marek Jakóbisiak, Jakub Golab
Pages: 1371-1375
Published online on: 01 December 2004

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Journal Cover
July-2026 Volume 56 Issue 1

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Journal Metrics

Impact Factor: 3.9

CiteScore: 8.3

CiteScore Rank: Q1: #73/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Review

Advances in Kruppel‑like factor 5 as a transcription factor and its role in gynecological tumors (Review)

Shuqi Zhang, Ping Li, Lixia Zhu
Article Number: 139
Published online on: 28 May 2026

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Review Open Access

Ferroptosis in colorectal cancer: Molecular mechanisms and regulatory crosstalk with therapeutic prospects (Review)

Mingxing Wu, Mingrong Zhang
Article Number: 138
Published online on: 27 May 2026

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Correction Open Access

[Corrigendum] 17‑AAG synergizes with Belinostat to exhibit a negative effect on the proliferation and invasion of MDA‑MB‑231 breast cancer cells

Yu Zuo, Heng Xu, Zhifeng Chen, Fengmin Xiong, Bei Zhang, Kaixian Chen, Hualiang Jiang, Cheng Luo, Hao Zhang
Article Number: 137
Published online on: 27 May 2026

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Review Open Access

Targeting lung cancer with tanshinones: Current mechanistic evidence and emerging opportunities (Review)

Zhengqi Guo, Xiaoci Li, Pengyu Suo, Zhanyu Lin, Ruixin Liu, Chenyu Chi
Article Number: 136
Published online on: 26 May 2026

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Review Open Access

Immune network remodeling driven by ferroptosis: Bidirectional interaction mechanisms among multiple immune cells in the lung cancer immune microenvironment (Review)

Fei Qu, Jiale Tong, Weiwei Qian, Qian He
Article Number: 135
Published online on: 26 May 2026

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Correction Open Access

[Corrigendum] Rapamycin enhances the sensitivity of ER‑positive breast cancer cells to tamoxifen by upregulating p73 expression

Lei Zhu, Xiao-Xia Li, Liang Shi, Jing Wu, Jia-Yi Qian, Tian-Song Xia, Wen-Bin Zhou, Xi Sun, Xu-Jie Zhou, Ji-Fu Wei, Qiang Ding
Article Number: 134
Published online on: 20 May 2026

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Review Open Access

Dual roles of lactylation modification in gastric cancer: Crosstalk between metabolic reprogramming and epigenetic regulation (Review)

Yuanbo Xu, Weili Wang, Yating Zhang, Yinqiu Fan, Wanying Dong, Jun Yang
Article Number: 133
Published online on: 20 May 2026

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Retraction Open Access

[Retracted] Hsp90 inhibitor 17‑AAG inhibits stem cell‑like properties and chemoresistance in osteosarcoma cells via the Hedgehog signaling pathway

Xiong Shu, Huiqi Liu, Rui Zhen, Yongsheng Jie, Lei Chen, Hui Qi, Chao Wang, Renxian Wang, Dafu Chen, Yuliang Ran
Article Number: 132
Published online on: 18 May 2026

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Article Open Access

Combination of ivermectin and metformin promotes autophagy in MCF‑7 cells by inhibiting phosphorylation of the PI3K/AKT/mTOR pathway

Huili Feng, Lixin He, Talha Umar, Haipeng Wang, Yanling Gao, Gongyi Chen, Panfeng Sun, Ling Yin, Wenbin Zhao, Huifang Lu, Ganzhen Deng, Changwei Qiu
Article Number: 131
Published online on: 14 May 2026

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Correction Open Access

[Corrigendum] ENO2 affects the EMT process of renal cell carcinoma and participates in the regulation of the immune micro­environment

Wei-Jie Chen, Wei Yang, Min Gong, Yi He, Da Xu, Jia-Xin Chen, Wen-Jin Chen, Wen-Yan Li, Yu-Qi Wang, Ke-Qin Dong, Xu Song, Xiu-Wu Pan, Xin-Gang Cui
Article Number: 130
Published online on: 13 May 2026

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Article Open Access

SRRT promotes prostate cancer progression and serves as a prognostic biomarker through STAT3 pathway activation

Lingxiang Lu, Ke Wu, Zhenfan Wang, Ruoxi Yang, Kai Li, Shuai Guo, Fei Wang, Zheng Ma
Article Number: 129
Published online on: 13 May 2026

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Retraction Open Access

[Retracted] Hsp72 controls bortezomib‑induced HepG2 cell death via interaction with pro‑apoptotic factors 

Giuseppe Calvaruso, Michela Giuliano, Patrizia Portanova, Ornella Pellerito, Renza Vento, Giovanni Tesoriere
Article Number: 128
Published online on: 11 May 2026

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Article Open Access

Effect of the miR‑26a/b‑5p‑STAT3‑YKL‑40 regulatory axis on proliferation, migration, and invasion of endometrial cancer cells

Xinzhao Sun, Shanshan Lin, Xueyan Zhong, Yanlu Luo, Jiahuang Yang, Jiangtao Fan
Article Number: 127
Published online on: 08 May 2026

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Review Open Access

Cancer signaling networks in tumor progression and drug resistance: Crosstalk, adaptive reprogramming and therapeutic targeting (Review)

Hongyan Li, Shiyuan Song, Linlin Wang, Qiang Liu
Article Number: 126
Published online on: 08 May 2026

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Article Open Access

A novel regulatory role of microRNA‑5590‑3p in hepatocellular carcinoma via the HOXB2/MYC axis

Bin Li, Lin Zhou
Article Number: 125
Published online on: 07 May 2026

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Retraction Open Access

[Retracted] SHIP1 is targeted by miR‑155 in acute myeloid leukemia

Hua Xue, Luo-Ming Hua, Ming Guo, Jian-Min Luo
Article Number: 124
Published online on: 05 May 2026

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Review Open Access

Chronic stress and cancer progression through neuro‑endocrine‑immune networks (Review)

Zhangxiang Zhu, Xiaohu Zhang, Jing Yan, Mingquan Wang, Yang Lv, Wuqiong Zhang, Hui Guo, Aimei Zheng
Article Number: 123
Published online on: 04 May 2026

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Retraction Open Access

[Retracted] PTEN enhances G2/M arrest in etoposide‑treated MCF‑7 cells through activation of the ATM pathway

Ruopeng Zhang, Li Zhu, Lirong Zhang, Anli Xu, Zhengwei Li, Yijuan Xu, Pei He, Maoqing Wu, Fengxiang Wei, Chenhong Wang
Article Number: 122
Published online on: 29 April 2026

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Journal Cover
August-2026 Volume 56 Issue 2

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Journal Metrics

Impact Factor: 3.9

CiteScore: 8.3

CiteScore Rank: Q1: #73/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Review Open Access

Sterol regulatory element‑binding proteins: Master regulators of lipid metabolic reprogramming in cancer and emerging therapeutic targets (Review)

Qing Liu, Rui Wang, Zhenbo Li, Yihan Liu, Lei Wu, Yuqin Zhao, Jing Yang
Article Number: 144
Published online on: 04 June 2026

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Review Open Access

Dual targeting of mitochondrial metabolism and Rho GTPase signaling to suppress cancer metastasis (Review)

Angelina Daher, Zahraa Assi, Amjad Kanaan, Ahmad Al Khatib, Mirvat El Sibai
Article Number: 143
Published online on: 03 June 2026

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Review Open Access

Targeting colorectal cancer and T‑cell metabolism for the treatment of colorectal cancer (Review)

Qiangzong Yu, Pengbo Luan, Jingru Liang, Lixin Wang
Article Number: 142
Published online on: 02 June 2026

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Expression of Concern Open Access

[Expression of Concern] Antitumor activity of Notch‑1 inhibition in human colorectal carcinoma cells

Wangdi Liao, Guohua Li, Yu You, Hongping Wan, Qiong Wu, Chongwen Wang, Nonghua Lv
Article Number: 141
Published online on: 02 June 2026

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Acylglycerol kinase contributes to cell proliferation by activating NF‑κB signaling pathway in pancreatic cancer

Kunkun Han, Qianyun Zhang, Shengnan Gao, Jigang Zhang, Xiao Mei, Fei Li, Xin Xu, Shu Li, Guodong Chen
Article Number: 140
Published online on: 29 May 2026

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