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Print ISSN: 1021-335X Online ISSN: 1791-2431
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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
December 2004 Volume 12 Issue 6

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Journal Metrics

Impact Factor: 4.7

CiteScore: 7.7

CiteScore Rank: Q1: #76/428 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Article

Plasminogen activator inhibitor type-1 mutants regulate angiogenesis of human umbilical and lung vascular endothelial cells

Joanna Chorostowska-Wynimko, Rafal Swiercz, Ewa Skrzypczak-Jankun, Steven H. Selman, Jerzy Jankun
Pages: 1155-1162
Published online on: 01 December 2004

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Article

Relationship between immunohistochemical evaluation of thymidylate synthase and proliferating cell nuclear antigen labeling index in gastrointestinal carcinoma

Yukihiro Kunimoto, Takeshi Nakamura, Masakazu Ohno, Yoshikazu Kuroda
Pages: 1163-1167
Published online on: 01 December 2004

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Article

Suppressive effect of CPT-11 on rat esophageal tumorigenesis induced by N-nitrosomethylbenzylamine

Yushi Fukiwara, Harushi Osugi, Keichirou Morimura, Masashi Takemura, Shigeru Lee, Kazuhiro Hirohashi, Shoji Fukushima, Shigefumi Suehiro
Pages: 1169-1176
Published online on: 01 December 2004

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Article

Amplicon profiling reveals cytoplasmic overexpression of MUC1 protein as an indicator of resistance to platinum-based chemotherapy in patients with ovarian cancer

Masashi Takano, Kazuyuki Fujii, Tsunekazu Kita, Yoshihiro Kikuchi, Kazuhiko Uchida
Pages: 1177-1182
Published online on: 01 December 2004

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Article

Induction of apoptosis by maackiain and trifolirhizin (maackiain glycoside) isolated from sanzukon (Sophora Subprostrate Chen et T. Chen) in human promyelotic leukemia HL-60 cells

Yue Aratanechemuge, Hiroshige Hibasami, Hirotaka Katsuzaki, Kunio Imai, Takashi Komiya
Pages: 1183-1188
Published online on: 01 December 2004

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Article

Expression of survivin mRNA associates with apoptosis, proliferation and histologically aggressive features in hepatocellular carcinoma

Soichiro Morinaga, Yoshiyasu Nakamura, Naoki Ishiwa, Takaki Yoshikawa, Yoshikazu Noguchi, Yuji Yamamoto, Yasushi Rino, Toshio Imada, Yoshinori Takanashi, Makoto Akaike, Yukio Sugimasa, Shoji Takemiya
Pages: 1189-1194
Published online on: 01 December 2004

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Article

Intrinsic radiosensitivity by metallothionein expression has no great influence on clinical radiosensitivity in esophageal carcinoma

Takuma Nomiya, Kenji Nemoto, Eiko Nakata, Hideo Miyachi, Yoshihiro Takai, Shogo Yamada
Pages: 1195-1199
Published online on: 01 December 2004

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Article

P-glycoprotein 170 expression and function as an adverse independent prognostic factor in childhood acute lymphoblastic leukemia

F. Casale, V. D'Angelo, R. Addeo, M. Caraglia, S. Crisci, R. Rondelli, M. T. Di Tullio, P. Indolfi
Pages: 1201-1207
Published online on: 01 December 2004

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Article

Nitric oxide production in fluoro-edenite treated mouse monocyte-macrophage cultures

Venera Cardile, Lidia Proietti, Annamaria Panico, Laura Lombardo
Pages: 1209-1215
Published online on: 01 December 2004

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Article

The role of hMSH3 and hMSH6 in ovarian endometrioid carcinoma and relationship with microsatellite instability phenotype

Constance T. Albarracin, Elvio G. Silva, Anais Malpica, Rajalakshmi Luthra, Jinsong Liu
Pages: 1217-1219
Published online on: 01 December 2004

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Article

Assessment of K-ras, Smad4 and p53 gene alterations in colorectal metastases and their role in the metastatic process

Lorena Losi, Gabriele Luppi, Jean Benhattar
Pages: 1221-1225
Published online on: 01 December 2004

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Article

Demonstration of human telomerase reverse transcriptase by in situ hybridization in lung carcinoma

Mitsuhiro Fukushima, Naotaka Shimomura, Ken-Ichi Nakamura, Makoto Kammori, Kiyoshi Koizumi, Kazuo Shimizu, Kaiyo Takubo
Pages: 1227-1232
Published online on: 01 December 2004

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Article

Methyl jasmonate induces apoptosis through induction of Bax/Bcl-Xs and activation of caspase-3 via ROS production in A549 cells

Ji Hye Kim, Su Yeon Lee, Su Young Oh, Song Iy Han, Hye Gyeong Park, Mi-Ae Yoo, Ho Sung Kang
Pages: 1233-1238
Published online on: 01 December 2004

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Article

Cdx2 expression in pancreatic tumors: Relationship with prognosis of invasive ductal carcinomas

Kakuya Matsumoto, Tsutomu Mizoshita, Tetsuya Tsukamoto, Naotaka Ogasawara, Akihiro Hirata, Yasuhiro Shimizu, Masakazu Haneda, Kenji Yamao, Masae Tatematsu
Pages: 1239-1243
Published online on: 01 December 2004

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Article

mRNA and protein expression of PUMA in sporadic colorectal cancer

Agneta Jansson, Gunnar Arbman, Xiao-Feng Sun
Pages: 1245-1249
Published online on: 01 December 2004

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Article

Characterization of stage-specific embryonic antigen-1 expression during early stages of human embryogenesis

Shanrong Liu, Houqi Liu, Shuping Tang, Yuqiong Pan, Kaihong Ji, Hui Ning, Shuling Wang, Zhongtian Qi, Lingsong Li
Pages: 1251-1256
Published online on: 01 December 2004

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Article

Utility of initial MRI for predicting extent of residual disease after neoadjuvant chemotherapy: Analysis of 70 breast cancer patients

Yoriko Murata, Yasuhiro Ogawa, Shoji Yoshida, Kei Kubota, Satoshi Itoh, Mitsutaka Fukumoto, Akihito Nishioka, Toshiaki Moriki, Hironori Maeda, Yosuke Tanaka
Pages: 1257-1262
Published online on: 01 December 2004

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Article

TU12B1-TY, a novel gene in the region at 12q22-q23.1 frequently deleted in pancreatic cancer, shows reduced expression in pancreatic cancer cells

Toshimasa Yatsuoka, Toru Furukawa, Makoto Sunamura, Seiki Matsuno, Akira Horii
Pages: 1263-1268
Published online on: 01 December 2004

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Article

Hotspot mutations of BRAF gene are not associated with pediatric solid neoplasms

Jiangyong Miao, Takeshi Kusafuka, Masahiro Fukuzawa
Pages: 1269-1272
Published online on: 01 December 2004

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Article

Loss of imprinting of PEG1/MEST in lung cancer cell lines

Hirofumi Nakanishi, Tetsuji Suda, Motonobu Katoh, Akiko Watanabe, Tadashi Igishi, Masahiro Kodani, Shingo Matsumoto, Masaki Nakamoto, Yasushi Shigeoka, Tetsuro Okabe, Mitsuo Oshimura, Eiji Shimizu
Pages: 1273-1278
Published online on: 01 December 2004

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Article

Effects of thymidine phosphorylase levels in cancer, background mucosa, and regional lymph nodes on survival of advanced gastric cancer patients receiving postoperative fluoropyrimidine therapy

Takeo Kosaka, Kazuo Usami, Nobuo Ueshige, Junichi Sugaya, Yasuharu Nakano, Shigeki Takashima
Pages: 1279-1286
Published online on: 01 December 2004

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Article

Gene expression in response to anti-tumour intervention by polysaccharide-K (PSK) in colorectal carcinoma cells

Reigetsu Yoshikawa, Hidenori Yanagi, Tomoko Hashimoto-Tamaoki, Tomonori Morinaga, Yoshiro Nakano, Masafumi Noda, Yoshinori Fujiwara, Haruki Okamura, Takehira Yamamura
Pages: 1287-1293
Published online on: 01 December 2004

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Article

Long-term survival of patients with advanced colorectal cancer may not be due to the response to chemotherapy

George P. Stathopoulos, Sotiris K. Rigatos, Nicos A. Malamos, John G. Stathopoulos, Panayiota Thallasinou, Ekaterini Papazachariou, Fotini Antoniou, Emmanuel Kondopodis, John Xynotroulas
Pages: 1295-1300
Published online on: 01 December 2004

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Article

Predicting recurrence and metastasis of stage III/Dukes' C colorectal cancer with lymph node metastasis

Masaya Mukai, Shinkichi Sato, Tomomi Kimura, Hiromi Ninomiya, Nobukazu Komatsu, Takayuki Tajima, Hisao Nakasaki, Hiroyasu Makuuchi
Pages: 1301-1304
Published online on: 01 December 2004

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Article

Predicting recurrence and metastasis of Dukes' A primary colorectal cancer with or without proper muscle invasion

Masaya Mukai, Shinkichi Sato, Hiromi Ninomiya, Tomomi Kimura, Nobukazu Komatsu, Takayuki Tajima, Hisao Nakasaki, Hiroyasu Makuuchi
Pages: 1305-1308
Published online on: 01 December 2004

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Article

ErbB2 oncogene antibodies differentiate between the normal and diseased pancreas, and between chronic pancreatitis and pancreatic cancer

Jens Standop, Matthias Schneider, Alexis Ulrich, Guenther Mathiak, Randall E. Brand, Markus W. Buechler, Parviz M. Pour
Pages: 1309-1315
Published online on: 01 December 2004

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Article

Immunohistochemical staining of metallothionein in canine mammary tumors: better survival with higher expression

Sérgio Vitorino Cardoso, Marcelo Vidigal Caliari, Maria Cássia Ferreira de Aguiar, Geovanni Dantas Cassali
Pages: 1317-1321
Published online on: 01 December 2004

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Article

Inactivation of HTB63 human melanoma cells by irradiation with protons and gamma rays

Aleksandra Ristic-Fira, Ivan Petrovic, Danijela Todorovic, Lela Koricanac, Miroslava Vujèic, Miroslav Demajo, Gabriella Sabini, Pablo Cirrone, Giacomo Cuttone
Pages: 1323-1328
Published online on: 01 December 2004

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Article

Response of T and B lymphocytes in the spleen, lymph nodes and mammary tumors in rats treated with human soluble tumor-associated antigens and commercial human albumin

Herzl Ben-Hur, George Kossoy, Herbert Mehrdad, Asher Elhayany, Itshak Zusman
Pages: 1329-1333
Published online on: 01 December 2004

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Article

Frequent CYP1A1 expression in gastric cancers and their related lesions

Kai-Li Zhang, Jing-Xin Ma, Xiao-Yan Chen, Yuan Sun, Qing-You Kong, Jia Liu, Hong Li
Pages: 1335-1340
Published online on: 01 December 2004

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Article

PTEN and DMBT1 homozygous deletion and expression in medulloblastomas and supratentorial primitive neuroectodermal tumors

María Del Mar Inda, Javier Mercapide, Jorge Muñoz, Philippe Coullin, Giséle Danglot, Teresa Tuñon, José María Martínez-Peñuela, José María Rivera, Juan J. Burgos, Alain Bernheim, Javier S. Castresana
Pages: 1341-1347
Published online on: 01 December 2004

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Article

The role of Raf-1 in radiation resistance of human hepatocellular carcinoma Hep G2 cells

W. Y. Tang, Sophia P.Y. Chau, W. P. Tsang, S. K. Kong, T. T. Kwok
Pages: 1349-1354
Published online on: 01 December 2004

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Article

Expression levels of melanoma inhibitory activity correlate with time to progression in patients with high-grade glioma

Peter Hau, Petra Ruemmele, Leoni A. Kunz-Schughart, Anett Doerfelt, Birgit Hirschmann, Annette Lohmeier, Horst Koch, Adolf Mueller, Ulrich Bogdahn, Anja-Katrin Bosserhoff
Pages: 1355-1364
Published online on: 01 December 2004

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Article

Effect of lung resistance-related protein on the resistance to cisplatin in human ovarian cancer cell lines

Wei Wang, Shunan Ke, Gang Chen, Qinglei Gao, Sufang Wu, Shixuan Wang, Jianfeng Zhou, Xiaokui Yang, Yunping Lu, Ding Ma
Pages: 1365-1370
Published online on: 01 December 2004

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Article

Lovastatin potentiates antitumor effects of saquinavir against human lymphoma cells

Tadeusz Issat, Dominika Nowis, Marek Jakóbisiak, Jakub Golab
Pages: 1371-1375
Published online on: 01 December 2004

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Journal Cover
November-2026 Volume 56 Issue 5

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Journal Metrics

Impact Factor: 4.7

CiteScore: 7.7

CiteScore Rank: Q1: #76/428 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Article Open Access

Targeting the DNHD1‑HDAC6 axis inactivates prostate cancer cell aggressiveness in vitro, suggesting potential therapeutic vulnerability

An Ni Lee, Chia Chang Wu, Su Wei Hu, Chih Heng Chen, Yi Te Chiang, Wei Tang Kao, Kai Yi Tzou, Chia Hung Liu, Shao Wei Dong, Yu Ting Wang, Yueh Lin Lee, Siou Bi Li, Che An Wu, Chiao Chun Liao, Ming Hsien Chan, Po Han Chiu, Chien Hsiu Li
Article Number: 198
Published online on: 30 September 2026

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Article Open Access

Loperamide enhances the radiosensitivity of cervical cancer cells via ferroptosis induction

Huarong Guo, Haixia Li, Shunkang Tian, Yunkai Zhang, Fuyun Wu, Jing Ke
Article Number: 197
Published online on: 30 September 2026

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Review Open Access

Mitochondrial mechanisms underlying spatial immune phenotypes in non‑small cell lung cancer: Implications for ICI response and cold‑to‑hot tumor conversion (Review)

Hongyi Lai, Ke Sun, Tong Mu, Xi Liu, Mingshan Liu
Article Number: 196
Published online on: 30 September 2026

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Article Open Access

PINK1 promotes the progression of lung squamous cell carcinoma through the FAK/AKT/RhoA/vinculin pathway

Xu Li, Yuhui Ma
Article Number: 195
Published online on: 29 September 2026

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Expression of Concern Open Access

[Expression of Concern] MicroRNA‑195‑5p is a potential diagnostic and therapeutic target for breast cancer

Qifeng Luo, Chuankui Wei, Xiaoyu Li, Jia Li, Lei Chen, Yixiang Huang, Hongming Song, Dengfeng Li, Lin Fang
Article Number: 194
Published online on: 23 September 2026

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Article Open Access

SGPP1 as a tumor suppressor in esophageal squamous cell carcinoma: Potential molecular mechanisms involving UGT1A9/UGT2B28 and clinical prognostic significance

Linlin Su, Liubing Hou, Xuetao Han, Ge Zhang, Jiayuan Li, Yu Wang, Yuxin Han, Xiaoying Xue, Huandi Zhou
Article Number: 193
Published online on: 23 September 2026

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Correction Open Access

[Corrigendum] High expression of hnRNPA1 promotes cell invasion by inducing EMT in gastric cancer

Yahua Chen, Jun Liu, Wei Wang, Li Xiang, Jide Wang, Side Liu, Hongyan Zhou, Zheng Guo
Article Number: 192
Published online on: 21 September 2026

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Review Open Access

Overcoming melanoma drug resistance: Mechanisms and clinical progress of oncolytic viruses combined with immune checkpoint inhibitors (Review)

Yuan He, Wenxuan Lin, Haofang Chen, Yongqi Guan, Congcong Guan, Yanxiang Zhang, Dongsheng Pan
Article Number: 191
Published online on: 17 September 2026

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Article Open Access

Validation of next‑generation sequencing‑derived circulating mRNA variants as potential diagnostic tools in hepatocellular carcinoma and cholangiocarcinoma

Daniel Zezulinski, Maarouf A. Hoteit, David E. Kaplan, Tingting Zhan, Cataldo Doria, Timothy M. Block, Aejaz Sayeed
Article Number: 190
Published online on: 16 September 2026

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Correction Open Access

[Corrigendum] The interaction between miR‑148a and DNMT1 suppresses cell migration and invasion by reactivating tumor suppressor genes in pancreatic cancer

Le Hong, Gen Sun, Long Peng, Yi Tu, Zhen Wan, Haiwei Xiong, Yong Li, Weidong Xiao
Article Number: 189
Published online on: 16 September 2026

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Article Open Access

Pemetrexed increases BRCA1 protein stability and sensitizes TNBC cells to radiotherapy

Hee Jin, Kyung-Hwa Jeon, Chaerin Kang, Joohyun Lee, Yeonjin Lee, Youngjoo Kwon, Yun-Sil Lee
Article Number: 188
Published online on: 15 September 2026

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Article Open Access

FXYD5 promotes the growth of glioblastoma by targeting the PI3K/AKT/ACSL4 signaling axis

Bang Wang, Yong Qin, Hang Cheng, Yibin Zeng, Lianglei Jiang, Xuebin Hu
Article Number: 187
Published online on: 14 September 2026

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Expression of Concern Open Access

[Expression of Concern] RIP kinase‑mediated ROS production triggers XAF1 expression through activation of TAp73 in casticin‑treated bladder cancer cells

Yoon Hee Chung, Daejin Kim
Article Number: 186
Published online on: 14 September 2026

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Expression of Concern Open Access

[Expression of Concern] In vitro and in vivo activities of an antitumor peptide HM‑3: A special dose‑efficacy relationship on an HCT‑116 xenograft model in nude mice

Sitelbanat Yassin, Jialiang Hu, Hanmei Xu, Ce Li, Sarra Setrerrahmane
Article Number: 185
Published online on: 10 September 2026

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Article Open Access

Effect of EZH2 regulation of the JAK2/STAT3 signaling pathway on proliferation and apoptosis in non‑small cell lung cancer cells

Shuang Wu, Wei Zhang
Article Number: 184
Published online on: 08 September 2026

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Correction Open Access

[Corrigendum] TGF‑β1 mediates epithelial to mesenchymal transition via the TGF‑β/Smad pathway in squamous cell carcinoma of the head and neck

Changyun Yu, Yong Liu, Donghai Huang, Yaozhang Dai, Gengming Cai, Jinjie Sun, Ting Xu, Yongquan Tian, Xin Zhang
Article Number: 183
Published online on: 31 August 2026

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Journal Cover
December-2026 Volume 56 Issue 6

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Journal Metrics

Impact Factor: 4.7

CiteScore: 7.7

CiteScore Rank: Q1: #76/428 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Expression of Concern Open Access

[Expression of Concern] ZNF703 promotes tumor cell proliferation and invasion and predicts poor prognosis in patients with colorectal cancer

Feng Ma, Lihong Bi, Gongli Yang, Mengnan Zhang, Cuiping Liu, Yingying Zhao, Yadong Wang, Jide Wang, Yang Bai, Yali Zhang
Article Number: 199
Published online on: 30 September 2026

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