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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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December 2004 Volume 12 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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December 2004 Volume 12 Issue 6

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Article

The role of hMSH3 and hMSH6 in ovarian endometrioid carcinoma and relationship with microsatellite instability phenotype

  • Authors:
    • Constance T. Albarracin
    • Elvio G. Silva
    • Anais Malpica
    • Rajalakshmi Luthra
    • Jinsong Liu

  • View Affiliations / Copyright

    Affiliations: The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA
  • Pages: 1217-1219
    |
    Published online on: December 1, 2004
       https://doi.org/10.3892/or.12.6.1217
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Abstract

Frequent frameshift mutations in the DNA mismatch repair genes hMSH3, and hMSH6, have been reported in colorectal and endometrial cancers with microsatellite instability, however, it is unclear whether they are similarly altered in ovarian endometrioid carcinoma. In this study, we examined frequency of frameshift mutation and protein expression in hMSH3 and hMSH6 in ovarian endometrioid carcinoma with or without microsatellite instability. Only 1 frameshift mutation of the 16 cases with microsatellite instability-high phenotype (6%) was detected in poly(A)8 tract of the hMSH3, but not in poly(C)8 tract of hMSH6 genes. In addition, none of the 6 microsatellite instability-low or 20 microsatellite-stable tumors showed mutations in these regions in either gene. These results indicate that mutations in the mono-nucleotide tracts of hMSH3 and hMSH6 are infrequent in ovarian endometrioid adenocarcinomas, other mechanisms may play a more important role in the development of these tumors.

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Copy and paste a formatted citation
Spandidos Publications style
Albarracin CT, Silva EG, Malpica A, Luthra R and Liu J: The role of hMSH3 and hMSH6 in ovarian endometrioid carcinoma and relationship with microsatellite instability phenotype. Oncol Rep 12: 1217-1219, 2004.
APA
Albarracin, C.T., Silva, E.G., Malpica, A., Luthra, R., & Liu, J. (2004). The role of hMSH3 and hMSH6 in ovarian endometrioid carcinoma and relationship with microsatellite instability phenotype. Oncology Reports, 12, 1217-1219. https://doi.org/10.3892/or.12.6.1217
MLA
Albarracin, C. T., Silva, E. G., Malpica, A., Luthra, R., Liu, J."The role of hMSH3 and hMSH6 in ovarian endometrioid carcinoma and relationship with microsatellite instability phenotype". Oncology Reports 12.6 (2004): 1217-1219.
Chicago
Albarracin, C. T., Silva, E. G., Malpica, A., Luthra, R., Liu, J."The role of hMSH3 and hMSH6 in ovarian endometrioid carcinoma and relationship with microsatellite instability phenotype". Oncology Reports 12, no. 6 (2004): 1217-1219. https://doi.org/10.3892/or.12.6.1217
Copy and paste a formatted citation
x
Spandidos Publications style
Albarracin CT, Silva EG, Malpica A, Luthra R and Liu J: The role of hMSH3 and hMSH6 in ovarian endometrioid carcinoma and relationship with microsatellite instability phenotype. Oncol Rep 12: 1217-1219, 2004.
APA
Albarracin, C.T., Silva, E.G., Malpica, A., Luthra, R., & Liu, J. (2004). The role of hMSH3 and hMSH6 in ovarian endometrioid carcinoma and relationship with microsatellite instability phenotype. Oncology Reports, 12, 1217-1219. https://doi.org/10.3892/or.12.6.1217
MLA
Albarracin, C. T., Silva, E. G., Malpica, A., Luthra, R., Liu, J."The role of hMSH3 and hMSH6 in ovarian endometrioid carcinoma and relationship with microsatellite instability phenotype". Oncology Reports 12.6 (2004): 1217-1219.
Chicago
Albarracin, C. T., Silva, E. G., Malpica, A., Luthra, R., Liu, J."The role of hMSH3 and hMSH6 in ovarian endometrioid carcinoma and relationship with microsatellite instability phenotype". Oncology Reports 12, no. 6 (2004): 1217-1219. https://doi.org/10.3892/or.12.6.1217
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