Cdx2 expression in pancreatic tumors: Relationship with prognosis of invasive ductal carcinomas

  • Authors:
    • Kakuya Matsumoto
    • Tsutomu Mizoshita
    • Tetsuya Tsukamoto
    • Naotaka Ogasawara
    • Akihiro Hirata
    • Yasuhiro Shimizu
    • Masakazu Haneda
    • Kenji Yamao
    • Masae Tatematsu
  • View Affiliations

  • Published online on: December 1, 2004     https://doi.org/10.3892/or.12.6.1239
  • Pages: 1239-1243
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Abstract

We have previously reported that Caudal-related homeobox gene 2 (Cdx2) is a useful prognostic intestinal phenotypic marker for advanced gastric cancers. In this study, we examined Cdx2 expression and phenotype in pancreatic tumors. We evaluated 19 mucinous cystic tumors (MCTs), 17 intraductal papillary-mucinous tumors (IPMTs), and 41 invasive ductal carcinomas (IDCs) with regard to their gastrointestinal phenotype. The expression of Cdx2 was also assessed immunohistochemically. The lesions were phenotypically divided into 39 gastric (G type), 29 gastric and intestinal mixed (GI type), 3 intestinal (I type), and 6 null (N type) types, independent of the histopathological type. Most of the pancreatic tumors were thus judged to be the positive for gastric phenotypic members. Cdx2 nuclear staining demonstrated a close relation to the intestinal phenotypic expression in all three types (MCTs, IPMTs, and IDCs; p<0.05). In IDCs, Kaplan-Meier analysis of Cdx2 expression showed the Cdx2-positive group to have a significantly better outcome than their negative counterparts (p=0.015). In conclusion, our data suggest that Cdx2 might be necessary for intestinal phenotypic expression even in pancreatic tumor cells. In addition, Cdx2 expression in IDCs may be a novel prognostic marker for patient survival.

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December 2004
Volume 12 Issue 6

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Matsumoto K, Mizoshita T, Tsukamoto T, Ogasawara N, Hirata A, Shimizu Y, Haneda M, Yamao K and Tatematsu M: Cdx2 expression in pancreatic tumors: Relationship with prognosis of invasive ductal carcinomas. Oncol Rep 12: 1239-1243, 2004
APA
Matsumoto, K., Mizoshita, T., Tsukamoto, T., Ogasawara, N., Hirata, A., Shimizu, Y. ... Tatematsu, M. (2004). Cdx2 expression in pancreatic tumors: Relationship with prognosis of invasive ductal carcinomas. Oncology Reports, 12, 1239-1243. https://doi.org/10.3892/or.12.6.1239
MLA
Matsumoto, K., Mizoshita, T., Tsukamoto, T., Ogasawara, N., Hirata, A., Shimizu, Y., Haneda, M., Yamao, K., Tatematsu, M."Cdx2 expression in pancreatic tumors: Relationship with prognosis of invasive ductal carcinomas". Oncology Reports 12.6 (2004): 1239-1243.
Chicago
Matsumoto, K., Mizoshita, T., Tsukamoto, T., Ogasawara, N., Hirata, A., Shimizu, Y., Haneda, M., Yamao, K., Tatematsu, M."Cdx2 expression in pancreatic tumors: Relationship with prognosis of invasive ductal carcinomas". Oncology Reports 12, no. 6 (2004): 1239-1243. https://doi.org/10.3892/or.12.6.1239