Loss of imprinting of PEG1/MEST in lung cancer cell lines

  • Authors:
    • Hirofumi Nakanishi
    • Tetsuji Suda
    • Motonobu Katoh
    • Akiko Watanabe
    • Tadashi Igishi
    • Masahiro Kodani
    • Shingo Matsumoto
    • Masaki Nakamoto
    • Yasushi Shigeoka
    • Tetsuro Okabe
    • Mitsuo Oshimura
    • Eiji Shimizu
  • View Affiliations

  • Published online on: December 1, 2004     https://doi.org/10.3892/or.12.6.1273
  • Pages: 1273-1278
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Abstract

Paternally expressed imprinted gene 1/mesoderm-specific transcript (PEG1/MEST) is an imprinted gene expressed from the paternal allele. Recently, frequent loss of imprinting (LOI) of PEG1/MEST has been reported in lung adenocarcinomas. It is suggested that the LOI may be involved in pathogenesis of lung adenocarcinoma. In the present study, incidence of LOI of PEG1/MEST was examined in lung cancer cell lines, including small cell lung cancer (SCLC). Among 50 cell lines tested, 20 cell lines were heterozygous for the AflIII site of the PEG1/MEST gene. In these heterozygotes, biallelic expression was observed in 9 cell lines (45%), monoallelic in 11 (55%). In cell lines of non-small cell lung cancer (NSCLC), 62% (8 of 13) exhibited biallelic expression. In SCLC, only 1 of 7 cell lines (14%) showed biallelic expression. LOI of PEG1/MEST in the NSCLC cell line is significantly frequent compared with that in SCLC cell lines (p=0.043). This result supports the possibility that LOI may be related to tumorigenesis and malignant transformation, especially in NSCLC.

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December 2004
Volume 12 Issue 6

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Nakanishi H, Suda T, Katoh M, Watanabe A, Igishi T, Kodani M, Matsumoto S, Nakamoto M, Shigeoka Y, Okabe T, Okabe T, et al: Loss of imprinting of PEG1/MEST in lung cancer cell lines. Oncol Rep 12: 1273-1278, 2004.
APA
Nakanishi, H., Suda, T., Katoh, M., Watanabe, A., Igishi, T., Kodani, M. ... Shimizu, E. (2004). Loss of imprinting of PEG1/MEST in lung cancer cell lines. Oncology Reports, 12, 1273-1278. https://doi.org/10.3892/or.12.6.1273
MLA
Nakanishi, H., Suda, T., Katoh, M., Watanabe, A., Igishi, T., Kodani, M., Matsumoto, S., Nakamoto, M., Shigeoka, Y., Okabe, T., Oshimura, M., Shimizu, E."Loss of imprinting of PEG1/MEST in lung cancer cell lines". Oncology Reports 12.6 (2004): 1273-1278.
Chicago
Nakanishi, H., Suda, T., Katoh, M., Watanabe, A., Igishi, T., Kodani, M., Matsumoto, S., Nakamoto, M., Shigeoka, Y., Okabe, T., Oshimura, M., Shimizu, E."Loss of imprinting of PEG1/MEST in lung cancer cell lines". Oncology Reports 12, no. 6 (2004): 1273-1278. https://doi.org/10.3892/or.12.6.1273