Immunohistochemical staining of metallothionein in canine mammary tumors: better survival with higher expression

  • Authors:
    • Sérgio Vitorino Cardoso
    • Marcelo Vidigal Caliari
    • Maria Cássia Ferreira de Aguiar
    • Geovanni Dantas Cassali
  • View Affiliations

  • Published online on: December 1, 2004     https://doi.org/10.3892/or.12.6.1317
  • Pages: 1317-1321
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Abstract

Metallothioneins (MT) are small proteins able to strongly bind and therefore neutralize heavy-metal, free-radical and other genotoxic compounds. A close relationship between MT and zinc-finger motif-dependent transcription factors has also been shown, with implications on cell proliferation and survival. Human malignant neoplasms (e.g. breast cancer) usually present worse prognosis with increased MT content. We therefore evaluated the immunohistochemical expression of MT in a group of 15 canine mammary gland tumors. There was no relationship between MT immunostaining and histological type or malignancy grading of the lesions. Comparison of MT immunolabelling with the overall survival of the animals revealed that MT overexpression was related to better prognosis, a contrasting finding with the human counter-part. We considered that differential MT gene expression could be responsible for this variation, as observed for some human neoplasms of distinct embryonic origin, but further investigation is required to elucidate this topic.

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December 2004
Volume 12 Issue 6

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Cardoso SV, Caliari MV, Ferreira de Aguiar MC and Cassali GD: Immunohistochemical staining of metallothionein in canine mammary tumors: better survival with higher expression. Oncol Rep 12: 1317-1321, 2004
APA
Cardoso, S.V., Caliari, M.V., Ferreira de Aguiar, M.C., & Cassali, G.D. (2004). Immunohistochemical staining of metallothionein in canine mammary tumors: better survival with higher expression. Oncology Reports, 12, 1317-1321. https://doi.org/10.3892/or.12.6.1317
MLA
Cardoso, S. V., Caliari, M. V., Ferreira de Aguiar, M. C., Cassali, G. D."Immunohistochemical staining of metallothionein in canine mammary tumors: better survival with higher expression". Oncology Reports 12.6 (2004): 1317-1321.
Chicago
Cardoso, S. V., Caliari, M. V., Ferreira de Aguiar, M. C., Cassali, G. D."Immunohistochemical staining of metallothionein in canine mammary tumors: better survival with higher expression". Oncology Reports 12, no. 6 (2004): 1317-1321. https://doi.org/10.3892/or.12.6.1317