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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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January 2005 Volume 13 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Clinical relevance of MMP-9, MMP-2, TIMP-1 and TIMP-2 in colorectal cancer

  • Authors:
    • A. Morán
    • P. Iniesta
    • C. García-Aranda
    • C. De Juan
    • A. Díaz-López
    • A. Sánchez-Pernaute
    • A. J. Torres
    • E. Díaz-Rubio
    • J. L. Balibrea
    • M. Benito

  • View Affiliations / Copyright

    Affiliations: Departamento de Bioquímica y Biología Molecular, Facultad de Farmacia, Universidad Complutense, 28040-Madrid, Spain
  • Pages: 115-120
    |
    Published online on: January 1, 2005
       https://doi.org/10.3892/or.13.1.115
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Abstract

The main aim of this study was to evaluate the clinical relevance of Gelatinases in colorectal cancer (CRC). Ninety-five CRCs and their paired normal tissues were investigated to detect total levels of MMP-9, MMP-2, and the tissue inhibitors TIMP-1 and TIMP-2. Also, pro-MMP and MMP activity, and potential associations with clinical parameters were estimated. MMP-9, MMP-2 and TIMP-1 levels were greater in CRCs than in normal tissues, differences being significant for MMP-9 and TIMP-1. However, TIMP-2 showed significantly lower levels in tumour samples. Moreover, significant differences in the state of activation between gelatinases were found. TIMP-1 low levels were significantly associated with poor clinical outcome of patients. According to these data, different roles have to be attributed to MMP-2 and MMP-9 in CRC progression. Moreover, TIMP-1 level evaluation emerges as the main prognostic factor in relation to Gelatinases A and B activity in CRC.

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Copy and paste a formatted citation
Spandidos Publications style
Morán A, Iniesta P, García-Aranda C, De Juan C, Díaz-López A, Sánchez-Pernaute A, Torres AJ, Díaz-Rubio E, Balibrea JL, Benito M, Benito M, et al: Clinical relevance of MMP-9, MMP-2, TIMP-1 and TIMP-2 in colorectal cancer. Oncol Rep 13: 115-120, 2005.
APA
Morán, A., Iniesta, P., García-Aranda, C., De Juan, C., Díaz-López, A., Sánchez-Pernaute, A. ... Benito, M. (2005). Clinical relevance of MMP-9, MMP-2, TIMP-1 and TIMP-2 in colorectal cancer. Oncology Reports, 13, 115-120. https://doi.org/10.3892/or.13.1.115
MLA
Morán, A., Iniesta, P., García-Aranda, C., De Juan, C., Díaz-López, A., Sánchez-Pernaute, A., Torres, A. J., Díaz-Rubio, E., Balibrea, J. L., Benito, M."Clinical relevance of MMP-9, MMP-2, TIMP-1 and TIMP-2 in colorectal cancer". Oncology Reports 13.1 (2005): 115-120.
Chicago
Morán, A., Iniesta, P., García-Aranda, C., De Juan, C., Díaz-López, A., Sánchez-Pernaute, A., Torres, A. J., Díaz-Rubio, E., Balibrea, J. L., Benito, M."Clinical relevance of MMP-9, MMP-2, TIMP-1 and TIMP-2 in colorectal cancer". Oncology Reports 13, no. 1 (2005): 115-120. https://doi.org/10.3892/or.13.1.115
Copy and paste a formatted citation
x
Spandidos Publications style
Morán A, Iniesta P, García-Aranda C, De Juan C, Díaz-López A, Sánchez-Pernaute A, Torres AJ, Díaz-Rubio E, Balibrea JL, Benito M, Benito M, et al: Clinical relevance of MMP-9, MMP-2, TIMP-1 and TIMP-2 in colorectal cancer. Oncol Rep 13: 115-120, 2005.
APA
Morán, A., Iniesta, P., García-Aranda, C., De Juan, C., Díaz-López, A., Sánchez-Pernaute, A. ... Benito, M. (2005). Clinical relevance of MMP-9, MMP-2, TIMP-1 and TIMP-2 in colorectal cancer. Oncology Reports, 13, 115-120. https://doi.org/10.3892/or.13.1.115
MLA
Morán, A., Iniesta, P., García-Aranda, C., De Juan, C., Díaz-López, A., Sánchez-Pernaute, A., Torres, A. J., Díaz-Rubio, E., Balibrea, J. L., Benito, M."Clinical relevance of MMP-9, MMP-2, TIMP-1 and TIMP-2 in colorectal cancer". Oncology Reports 13.1 (2005): 115-120.
Chicago
Morán, A., Iniesta, P., García-Aranda, C., De Juan, C., Díaz-López, A., Sánchez-Pernaute, A., Torres, A. J., Díaz-Rubio, E., Balibrea, J. L., Benito, M."Clinical relevance of MMP-9, MMP-2, TIMP-1 and TIMP-2 in colorectal cancer". Oncology Reports 13, no. 1 (2005): 115-120. https://doi.org/10.3892/or.13.1.115
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