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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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February 2005 Volume 13 Issue 2

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

Expression levels of Akt in nimesulide-treated squamous carcinoma cell lines of the head and neck

  • Authors:
    • Laurenz Vormittag
    • Wolfgang Lamm
    • Boban M. Erovic
    • Cornelia Czembirek
    • Gabriela Kornek
    • Dietmar Thurnher

  • View Affiliations / Copyright

    Affiliations: Department of Internal Medicine, Division of Oncology, Medical University of Vienna, Waehringer Guertel 18-20, A-1090 Vienna, Austria
  • Pages: 207-210
    |
    Published online on: February 1, 2005
       https://doi.org/10.3892/or.13.2.207
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Abstract

Nimesulide, a selective cyclooxygenase-2 (COX-2) inhibitor, is known to induce apoptosis in various cell lines. So far, the molecular targets that account for this effect are unknown. Akt and extracellular-signal regulated kinase (ERK) are both important signaling molecules, which promote survival in different types of cancer, including head and neck cancer. The aim of our study was to describe the effect of treatment with nimesulide and ERK inhibitor PD 98059 on the expression patterns of Akt within the head and neck cancer cell lines SCC 9 and SCC 25. SCC 9 and SCC 25 cells were cultured in RPMI and treated with nimesulide and PD 98059. Protein expression levels were semi-quantified by Western blot analysis. Apoptosis was examined using the M30 antibody that binds to a caspase cleaved cytoskeletal protein for detection of early apoptosis in immunofluorescence studies. In both cell lines, nimesulide treatment induced apoptosis and resulted in a decrease of Akt expression. ERK inhibition had no effect on Akt expression, and combined application of both agents had the same effect as treatment with nimesulide alone. In conclusion, nimesulide induces apoptosis and promotes down-regulation of Akt-expression in squamous cell carcinoma cells, independently of ERK activity.

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Copy and paste a formatted citation
Spandidos Publications style
Vormittag L, Lamm W, Erovic BM, Czembirek C, Kornek G and Thurnher D: Expression levels of Akt in nimesulide-treated squamous carcinoma cell lines of the head and neck. Oncol Rep 13: 207-210, 2005.
APA
Vormittag, L., Lamm, W., Erovic, B.M., Czembirek, C., Kornek, G., & Thurnher, D. (2005). Expression levels of Akt in nimesulide-treated squamous carcinoma cell lines of the head and neck. Oncology Reports, 13, 207-210. https://doi.org/10.3892/or.13.2.207
MLA
Vormittag, L., Lamm, W., Erovic, B. M., Czembirek, C., Kornek, G., Thurnher, D."Expression levels of Akt in nimesulide-treated squamous carcinoma cell lines of the head and neck". Oncology Reports 13.2 (2005): 207-210.
Chicago
Vormittag, L., Lamm, W., Erovic, B. M., Czembirek, C., Kornek, G., Thurnher, D."Expression levels of Akt in nimesulide-treated squamous carcinoma cell lines of the head and neck". Oncology Reports 13, no. 2 (2005): 207-210. https://doi.org/10.3892/or.13.2.207
Copy and paste a formatted citation
x
Spandidos Publications style
Vormittag L, Lamm W, Erovic BM, Czembirek C, Kornek G and Thurnher D: Expression levels of Akt in nimesulide-treated squamous carcinoma cell lines of the head and neck. Oncol Rep 13: 207-210, 2005.
APA
Vormittag, L., Lamm, W., Erovic, B.M., Czembirek, C., Kornek, G., & Thurnher, D. (2005). Expression levels of Akt in nimesulide-treated squamous carcinoma cell lines of the head and neck. Oncology Reports, 13, 207-210. https://doi.org/10.3892/or.13.2.207
MLA
Vormittag, L., Lamm, W., Erovic, B. M., Czembirek, C., Kornek, G., Thurnher, D."Expression levels of Akt in nimesulide-treated squamous carcinoma cell lines of the head and neck". Oncology Reports 13.2 (2005): 207-210.
Chicago
Vormittag, L., Lamm, W., Erovic, B. M., Czembirek, C., Kornek, G., Thurnher, D."Expression levels of Akt in nimesulide-treated squamous carcinoma cell lines of the head and neck". Oncology Reports 13, no. 2 (2005): 207-210. https://doi.org/10.3892/or.13.2.207
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