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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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February 2005 Volume 13 Issue 2

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

Immunohistochemical analysis of p53 and MIB-1 in tissue specimens obtained from endoscopic ultrasonography-guided fine needle aspiration biopsy for the diagnosis of solid pancreatic masses

  • Authors:
    • Takao Itoi
    • Kazuo Takei
    • Atsushi Sofuni
    • Fumihide Itokawa
    • Takayoshi Tsuchiya
    • Toshio Kurihara
    • Kazuto Nakamura
    • Fuminori Moriyasu
    • Akihiko Tsuchida
    • Kazuhiko Kasuya

  • View Affiliations / Copyright

    Affiliations: Fourth Department of Internal Medicine, Tokyo Medical University, 6-7-1 Nishishinjuku, Shinjuku-ku, Tokyo, 160-0023, Japan. itoi@tokyo-med.ac.jp
  • Pages: 229-234
    |
    Published online on: February 1, 2005
       https://doi.org/10.3892/or.13.2.229
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Abstract

Endoscopic ultrasonography-guided fine-needle aspiration biopsy (EUS-FNAB) has been shown to be a highly accurate technique for distinguishing benign from malignant pancreatic masses. In this study, we examined p53 immunohistochemical analysis in FNAB specimens obtained from solid pancreatic diseases, and prospectively evaluated clinical applications for the diagnosis of malignancy in combination routine histological examination. Tissue specimens obtained from 62 pancreatic masses (51 pancreatic cancers and 11 chronic pancreatitis) by EUS-FNAB were evaluated by routine histological examination and p53 immunostaining. The conventional EUS-FNA diagnostic test statistics for the pancreatic masses were as follows: 76% sensitivity, 91% specificity and 79% accuracy. p53 protein overexpression was observed in 67% patients with pancreatic cancer, but not in patients with chronic pancreatitis. If the diagnosis of malignancy was made using the combination of p53 protein overexpression and conventional histological examination, the diagnostic test statistics changed as follows: 90% sensitivity, 91% specificity and 92% accuracy. p53 immunostaining in combination with routine histological examination of EUS-FNAB may improve the diagnostic accuracy for pancreatic cancer.

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Copy and paste a formatted citation
Spandidos Publications style
Itoi T, Takei K, Sofuni A, Itokawa F, Tsuchiya T, Kurihara T, Nakamura K, Moriyasu F, Tsuchida A, Kasuya K, Kasuya K, et al: Immunohistochemical analysis of p53 and MIB-1 in tissue specimens obtained from endoscopic ultrasonography-guided fine needle aspiration biopsy for the diagnosis of solid pancreatic masses. Oncol Rep 13: 229-234, 2005.
APA
Itoi, T., Takei, K., Sofuni, A., Itokawa, F., Tsuchiya, T., Kurihara, T. ... Kasuya, K. (2005). Immunohistochemical analysis of p53 and MIB-1 in tissue specimens obtained from endoscopic ultrasonography-guided fine needle aspiration biopsy for the diagnosis of solid pancreatic masses. Oncology Reports, 13, 229-234. https://doi.org/10.3892/or.13.2.229
MLA
Itoi, T., Takei, K., Sofuni, A., Itokawa, F., Tsuchiya, T., Kurihara, T., Nakamura, K., Moriyasu, F., Tsuchida, A., Kasuya, K."Immunohistochemical analysis of p53 and MIB-1 in tissue specimens obtained from endoscopic ultrasonography-guided fine needle aspiration biopsy for the diagnosis of solid pancreatic masses". Oncology Reports 13.2 (2005): 229-234.
Chicago
Itoi, T., Takei, K., Sofuni, A., Itokawa, F., Tsuchiya, T., Kurihara, T., Nakamura, K., Moriyasu, F., Tsuchida, A., Kasuya, K."Immunohistochemical analysis of p53 and MIB-1 in tissue specimens obtained from endoscopic ultrasonography-guided fine needle aspiration biopsy for the diagnosis of solid pancreatic masses". Oncology Reports 13, no. 2 (2005): 229-234. https://doi.org/10.3892/or.13.2.229
Copy and paste a formatted citation
x
Spandidos Publications style
Itoi T, Takei K, Sofuni A, Itokawa F, Tsuchiya T, Kurihara T, Nakamura K, Moriyasu F, Tsuchida A, Kasuya K, Kasuya K, et al: Immunohistochemical analysis of p53 and MIB-1 in tissue specimens obtained from endoscopic ultrasonography-guided fine needle aspiration biopsy for the diagnosis of solid pancreatic masses. Oncol Rep 13: 229-234, 2005.
APA
Itoi, T., Takei, K., Sofuni, A., Itokawa, F., Tsuchiya, T., Kurihara, T. ... Kasuya, K. (2005). Immunohistochemical analysis of p53 and MIB-1 in tissue specimens obtained from endoscopic ultrasonography-guided fine needle aspiration biopsy for the diagnosis of solid pancreatic masses. Oncology Reports, 13, 229-234. https://doi.org/10.3892/or.13.2.229
MLA
Itoi, T., Takei, K., Sofuni, A., Itokawa, F., Tsuchiya, T., Kurihara, T., Nakamura, K., Moriyasu, F., Tsuchida, A., Kasuya, K."Immunohistochemical analysis of p53 and MIB-1 in tissue specimens obtained from endoscopic ultrasonography-guided fine needle aspiration biopsy for the diagnosis of solid pancreatic masses". Oncology Reports 13.2 (2005): 229-234.
Chicago
Itoi, T., Takei, K., Sofuni, A., Itokawa, F., Tsuchiya, T., Kurihara, T., Nakamura, K., Moriyasu, F., Tsuchida, A., Kasuya, K."Immunohistochemical analysis of p53 and MIB-1 in tissue specimens obtained from endoscopic ultrasonography-guided fine needle aspiration biopsy for the diagnosis of solid pancreatic masses". Oncology Reports 13, no. 2 (2005): 229-234. https://doi.org/10.3892/or.13.2.229
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