Keratinocyte growth factor receptor expression in normal colorectal epithelial cells and differentiated type of colorectal cancer

  • Authors:
    • Masanori Yoshino
    • Toshiyuki Ishiwata
    • Masanori Watanabe
    • Osamu Komine
    • Tetsuo Shibuya
    • Akira Tokunaga
    • Zenya Naito
  • View Affiliations

  • Published online on: February 1, 2005     https://doi.org/10.3892/or.13.2.247
  • Pages: 247-252
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Abstract

The keratinocyte growth factor receptor, also known as KGFR/FGFR2 IIIb, is mainly localized in epithelial cells and participates in the proliferation of these cells. In the present study, we attempted to clarify the expression and role of KGFR in human colorectal cancer. The KGFR protein was detected in several colorectal cancer cell lines. Immuno-histochemically, KGFR was expressed on the luminal surface of epithelial cells in normal colorectal tissues. KGFR was expressed in 35 of 56 (62.5%) colorectal cancer patients and localized at the center of the cancer nests. Cytokeratin 20 (CK 20) colocalized with KGFR. In contrast, Ki-67 localized at the periphery of the cancer nests. Clinicopathologically, a high level of KGFR expression was associated with well-differentiated histological type (p<0.0001) and shallow wall invasion (p<0.0174). These findings indicate that KGFR may play important roles in the differentiation of normal colorectal epithelial cells and establishment of the well-differentiated histological type of colorectal cancer cells.

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February 2005
Volume 13 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Yoshino M, Ishiwata T, Watanabe M, Komine O, Shibuya T, Tokunaga A and Naito Z: Keratinocyte growth factor receptor expression in normal colorectal epithelial cells and differentiated type of colorectal cancer. Oncol Rep 13: 247-252, 2005
APA
Yoshino, M., Ishiwata, T., Watanabe, M., Komine, O., Shibuya, T., Tokunaga, A., & Naito, Z. (2005). Keratinocyte growth factor receptor expression in normal colorectal epithelial cells and differentiated type of colorectal cancer. Oncology Reports, 13, 247-252. https://doi.org/10.3892/or.13.2.247
MLA
Yoshino, M., Ishiwata, T., Watanabe, M., Komine, O., Shibuya, T., Tokunaga, A., Naito, Z."Keratinocyte growth factor receptor expression in normal colorectal epithelial cells and differentiated type of colorectal cancer". Oncology Reports 13.2 (2005): 247-252.
Chicago
Yoshino, M., Ishiwata, T., Watanabe, M., Komine, O., Shibuya, T., Tokunaga, A., Naito, Z."Keratinocyte growth factor receptor expression in normal colorectal epithelial cells and differentiated type of colorectal cancer". Oncology Reports 13, no. 2 (2005): 247-252. https://doi.org/10.3892/or.13.2.247