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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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February 2005 Volume 13 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Medicine International

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Article

Chromosomal radiosensitivity in breast cancer patients: Influence of age of onset of the disease

  • Authors:
    • Ans Baeyens
    • Rudy Van Den Broecke
    • Amin Makar
    • Hubert Thierens
    • Leo De Ridder
    • Anne Vral

  • View Affiliations / Copyright

    Affiliations: DDepartment of Anatomy, Embryology, Histology and Medical Physics, University of Ghent, L. Pasteurlaan 2, 9000 Ghent, Belgium
  • Pages: 347-353
    |
    Published online on: February 1, 2005
       https://doi.org/10.3892/or.13.2.347
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Abstract

The age dependency of onset of the disease on chromosomal radiosensitivity of an unselected group of breast cancer patients (n=100) was investigated and compared to a group of healthy women (n=100). The chromosomal radiosensitivity was assessed with the G2 and the G0 micro-nucleus (MN) assay. For the G2 assay lymphocytes were irradiated in vitro with a dose of 0.4 Gy 60Co γ-rays after 70 h incubation and chromatid breaks were scored in 50 metaphases. For the G0 MN assay lymphocytes were exposed in vitro to 3.5 Gy 60Co γ-rays at low dose rate (LDR). 72 h post-irradiation cultures were arrested and micronuclei were scored in 1000 binucleate cells. The results demonstrated that the group of breast cancer patients was more radiosensitive than a population of healthy women and this with both the G2 and the G0 MN assay. Analyses of the G2 and MN response in different age groups of the breast cancer patients revealed no significant differences in mean G2 and MN scores and suggest that the age of onset of the disease has no effect on chromosomal radiosensitivity in unselected breast cancer patients. Correlations with different clinical parameters were also investigated

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Copy and paste a formatted citation
Spandidos Publications style
Baeyens A, Van Den Broecke R, Makar A, Thierens H, De Ridder L and Vral A: Chromosomal radiosensitivity in breast cancer patients: Influence of age of onset of the disease. Oncol Rep 13: 347-353, 2005.
APA
Baeyens, A., Van Den Broecke, R., Makar, A., Thierens, H., De Ridder, L., & Vral, A. (2005). Chromosomal radiosensitivity in breast cancer patients: Influence of age of onset of the disease. Oncology Reports, 13, 347-353. https://doi.org/10.3892/or.13.2.347
MLA
Baeyens, A., Van Den Broecke, R., Makar, A., Thierens, H., De Ridder, L., Vral, A."Chromosomal radiosensitivity in breast cancer patients: Influence of age of onset of the disease". Oncology Reports 13.2 (2005): 347-353.
Chicago
Baeyens, A., Van Den Broecke, R., Makar, A., Thierens, H., De Ridder, L., Vral, A."Chromosomal radiosensitivity in breast cancer patients: Influence of age of onset of the disease". Oncology Reports 13, no. 2 (2005): 347-353. https://doi.org/10.3892/or.13.2.347
Copy and paste a formatted citation
x
Spandidos Publications style
Baeyens A, Van Den Broecke R, Makar A, Thierens H, De Ridder L and Vral A: Chromosomal radiosensitivity in breast cancer patients: Influence of age of onset of the disease. Oncol Rep 13: 347-353, 2005.
APA
Baeyens, A., Van Den Broecke, R., Makar, A., Thierens, H., De Ridder, L., & Vral, A. (2005). Chromosomal radiosensitivity in breast cancer patients: Influence of age of onset of the disease. Oncology Reports, 13, 347-353. https://doi.org/10.3892/or.13.2.347
MLA
Baeyens, A., Van Den Broecke, R., Makar, A., Thierens, H., De Ridder, L., Vral, A."Chromosomal radiosensitivity in breast cancer patients: Influence of age of onset of the disease". Oncology Reports 13.2 (2005): 347-353.
Chicago
Baeyens, A., Van Den Broecke, R., Makar, A., Thierens, H., De Ridder, L., Vral, A."Chromosomal radiosensitivity in breast cancer patients: Influence of age of onset of the disease". Oncology Reports 13, no. 2 (2005): 347-353. https://doi.org/10.3892/or.13.2.347
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