Importance of thymidine phosphorylase expression in tumor stroma as a prognostic factor in patients with advanced colorectal carcinoma

  • Authors:
    • Masamichi Yasuno
    • Takeo Mori
    • Morio Koike
    • Keiichi Takahashi
    • Masakazu Toi
    • Toichiro Takizawa
    • Shinichiro Shimizu
    • Tatsuro Yamaguchi
    • Hiroshi Matsumoto
  • View Affiliations

  • Published online on: March 1, 2005     https://doi.org/10.3892/or.13.3.405
  • Pages: 405-412
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Abstract

Thymidine phosphorylase (TP) is a unique enzyme involved not only in angiogenesis, but in 5-fluorouracil (5-FU) metabolism as well. TP is produced by both tumor and stromal cells. The aim of this study was to reveal the clinical implication of TP localization in tumor tissues. Advanced colorectal cancer specimens (n=97) were prepared for immunohistochemical staining using monoclonal antibodies against TP, p53, vascular endothelial growth factor (VEGF), factor VIII, CD68 and thymidylate synthase (TS). Clinicopathological factors and the clinical prognosis were examined for each indicator. High tumor TP expression and high stromal TP expression were observed in 38% (36/95 cases) and 49% (47/95 cases) of the cases, respectively. High tumor TP expression tended to correlate with microvessel density (MVD) (p=0.0511). Among patients who underwent curative resection, those with high stromal TP expression had a favorable prognosis (p=0.0127). High stromal TP status was also a strong prognostic factor in the group receiving adjuvant 5-FU derivatives (p=0.0222). TP produced by tumor cells has a stimulatory effect on tumor angiogenesis, while that produced by stromal cells plays an entirely different role. The latter may enhance the anticancer effect of 5-FU via its catalyzed function.

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March 2005
Volume 13 Issue 3

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Yasuno M, Mori T, Koike M, Takahashi K, Toi M, Takizawa T, Shimizu S, Yamaguchi T and Matsumoto H: Importance of thymidine phosphorylase expression in tumor stroma as a prognostic factor in patients with advanced colorectal carcinoma. Oncol Rep 13: 405-412, 2005
APA
Yasuno, M., Mori, T., Koike, M., Takahashi, K., Toi, M., Takizawa, T. ... Matsumoto, H. (2005). Importance of thymidine phosphorylase expression in tumor stroma as a prognostic factor in patients with advanced colorectal carcinoma. Oncology Reports, 13, 405-412. https://doi.org/10.3892/or.13.3.405
MLA
Yasuno, M., Mori, T., Koike, M., Takahashi, K., Toi, M., Takizawa, T., Shimizu, S., Yamaguchi, T., Matsumoto, H."Importance of thymidine phosphorylase expression in tumor stroma as a prognostic factor in patients with advanced colorectal carcinoma". Oncology Reports 13.3 (2005): 405-412.
Chicago
Yasuno, M., Mori, T., Koike, M., Takahashi, K., Toi, M., Takizawa, T., Shimizu, S., Yamaguchi, T., Matsumoto, H."Importance of thymidine phosphorylase expression in tumor stroma as a prognostic factor in patients with advanced colorectal carcinoma". Oncology Reports 13, no. 3 (2005): 405-412. https://doi.org/10.3892/or.13.3.405