Importance of thymidine phosphorylase expression in tumor stroma as a prognostic factor in patients with advanced colorectal carcinoma

Yasuno,Masamichi; Mori,Takeo; Koike,Morio; Takahashi,Keiichi; Toi,Masakazu; Takizawa,Toichiro; Shimizu,Shinichiro; Yamaguchi,Tatsuro; Matsumoto,Hiroshi

doi:10.3892/or.13.3.405

March 2005 Volume 13 Issue 3

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March 2005 Volume 13 Issue 3

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Article

Importance of thymidine phosphorylase expression in tumor stroma as a prognostic factor in patients with advanced colorectal carcinoma

Authors:
- Masamichi Yasuno
- Takeo Mori
- Morio Koike
- Keiichi Takahashi
- Masakazu Toi
- Toichiro Takizawa
- Shinichiro Shimizu
- Tatsuro Yamaguchi
- Hiroshi Matsumoto
View Affiliations / Copyright

Affiliations: Department of Surgical Oncology, Tokyo Medical and Dental University, 1-5-45 Yushima Bunkyou-ku, Tokyo 113-8519, Japan. yasuno.srg2@tmd.ac.jp
Pages: 405-412
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Published online on: March 1, 2005

https://doi.org/10.3892/or.13.3.405
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Abstract

Thymidine phosphorylase (TP) is a unique enzyme involved not only in angiogenesis, but in 5-fluorouracil (5-FU) metabolism as well. TP is produced by both tumor and stromal cells. The aim of this study was to reveal the clinical implication of TP localization in tumor tissues. Advanced colorectal cancer specimens (n=97) were prepared for immunohistochemical staining using monoclonal antibodies against TP, p53, vascular endothelial growth factor (VEGF), factor VIII, CD68 and thymidylate synthase (TS). Clinicopathological factors and the clinical prognosis were examined for each indicator. High tumor TP expression and high stromal TP expression were observed in 38% (36/95 cases) and 49% (47/95 cases) of the cases, respectively. High tumor TP expression tended to correlate with microvessel density (MVD) (p=0.0511). Among patients who underwent curative resection, those with high stromal TP expression had a favorable prognosis (p=0.0127). High stromal TP status was also a strong prognostic factor in the group receiving adjuvant 5-FU derivatives (p=0.0222). TP produced by tumor cells has a stimulatory effect on tumor angiogenesis, while that produced by stromal cells plays an entirely different role. The latter may enhance the anticancer effect of 5-FU via its catalyzed function.

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Importance of thymidine phosphorylase expression in tumor stroma as a prognostic factor in patients with advanced colorectal carcinoma

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Abstract

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