Stimulation of MCF-7 tumor progression in athymic nude mice by 17β-estradiol induces WISP-2/CCN5 expression in xenografts: A novel signaling molecule in hormonal carcinogenesis

  • Authors:
    • Gibanananda Ray
    • Snigdha Banerjee
    • Neela K. Saxena
    • Donald R. Campbell
    • Peter Van Veldhuizen
    • Sushanta K. Banerjee
  • View Affiliations

  • Published online on: March 1, 2005     https://doi.org/10.3892/or.13.3.445
  • Pages: 445-448
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Abstract

There was 100% solid tumor formation following inoculation of MCF-7 cells. However, MCF-7 tumor progression was significantly greater in the mice exposed to 17β-estradiol (17β-E2) compared to unexposed mice. WISP-2/CCN5 mRNA expression was correspondingly increased in 17β-E2 exposed MCF-7 tumors compared to unexposed xenografts. Moreover, estrogen exposure followed by anti-estrogen tamoxifen treatment drastically inhibited the tumor growth and WISP-2 expression in nude mice. Therefore, the study suggests that higher WISP-2/CCN5 expression by estrogen may be associated with the estrogen-induced growth of MCF-7 tumors in vivo. Finally, overexpression of WISP-2/CCN5 may be considered as a prognostic marker of estrogen-sensitive tumor growth.

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March 2005
Volume 13 Issue 3

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Ray G, Banerjee S, Saxena NK, Campbell DR, Van Veldhuizen P and Banerjee SK: Stimulation of MCF-7 tumor progression in athymic nude mice by 17β-estradiol induces WISP-2/CCN5 expression in xenografts: A novel signaling molecule in hormonal carcinogenesis. Oncol Rep 13: 445-448, 2005
APA
Ray, G., Banerjee, S., Saxena, N.K., Campbell, D.R., Van Veldhuizen, P., & Banerjee, S.K. (2005). Stimulation of MCF-7 tumor progression in athymic nude mice by 17β-estradiol induces WISP-2/CCN5 expression in xenografts: A novel signaling molecule in hormonal carcinogenesis. Oncology Reports, 13, 445-448. https://doi.org/10.3892/or.13.3.445
MLA
Ray, G., Banerjee, S., Saxena, N. K., Campbell, D. R., Van Veldhuizen, P., Banerjee, S. K."Stimulation of MCF-7 tumor progression in athymic nude mice by 17β-estradiol induces WISP-2/CCN5 expression in xenografts: A novel signaling molecule in hormonal carcinogenesis". Oncology Reports 13.3 (2005): 445-448.
Chicago
Ray, G., Banerjee, S., Saxena, N. K., Campbell, D. R., Van Veldhuizen, P., Banerjee, S. K."Stimulation of MCF-7 tumor progression in athymic nude mice by 17β-estradiol induces WISP-2/CCN5 expression in xenografts: A novel signaling molecule in hormonal carcinogenesis". Oncology Reports 13, no. 3 (2005): 445-448. https://doi.org/10.3892/or.13.3.445