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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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March 2005 Volume 13 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Stimulation of MCF-7 tumor progression in athymic nude mice by 17β-estradiol induces WISP-2/CCN5 expression in xenografts: A novel signaling molecule in hormonal carcinogenesis

  • Authors:
    • Gibanananda Ray
    • Snigdha Banerjee
    • Neela K. Saxena
    • Donald R. Campbell
    • Peter Van Veldhuizen
    • Sushanta K. Banerjee
  • View Affiliations / Copyright

    Affiliations: Cancer Research Unit, Research Division 151, V.A. Medical Center, 4801 Linwood Blvd., Kansas City, MO 64128, USA
  • Pages: 445-448
    |
    Published online on: March 1, 2005
       https://doi.org/10.3892/or.13.3.445
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Abstract

There was 100% solid tumor formation following inoculation of MCF-7 cells. However, MCF-7 tumor progression was significantly greater in the mice exposed to 17β-estradiol (17β-E2) compared to unexposed mice. WISP-2/CCN5 mRNA expression was correspondingly increased in 17β-E2 exposed MCF-7 tumors compared to unexposed xenografts. Moreover, estrogen exposure followed by anti-estrogen tamoxifen treatment drastically inhibited the tumor growth and WISP-2 expression in nude mice. Therefore, the study suggests that higher WISP-2/CCN5 expression by estrogen may be associated with the estrogen-induced growth of MCF-7 tumors in vivo. Finally, overexpression of WISP-2/CCN5 may be considered as a prognostic marker of estrogen-sensitive tumor growth.

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Copy and paste a formatted citation
Spandidos Publications style
Ray G, Banerjee S, Saxena NK, Campbell DR, Van Veldhuizen P and Banerjee SK: Stimulation of MCF-7 tumor progression in athymic nude mice by 17β-estradiol induces WISP-2/CCN5 expression in xenografts: A novel signaling molecule in hormonal carcinogenesis. Oncol Rep 13: 445-448, 2005.
APA
Ray, G., Banerjee, S., Saxena, N.K., Campbell, D.R., Van Veldhuizen, P., & Banerjee, S.K. (2005). Stimulation of MCF-7 tumor progression in athymic nude mice by 17β-estradiol induces WISP-2/CCN5 expression in xenografts: A novel signaling molecule in hormonal carcinogenesis. Oncology Reports, 13, 445-448. https://doi.org/10.3892/or.13.3.445
MLA
Ray, G., Banerjee, S., Saxena, N. K., Campbell, D. R., Van Veldhuizen, P., Banerjee, S. K."Stimulation of MCF-7 tumor progression in athymic nude mice by 17β-estradiol induces WISP-2/CCN5 expression in xenografts: A novel signaling molecule in hormonal carcinogenesis". Oncology Reports 13.3 (2005): 445-448.
Chicago
Ray, G., Banerjee, S., Saxena, N. K., Campbell, D. R., Van Veldhuizen, P., Banerjee, S. K."Stimulation of MCF-7 tumor progression in athymic nude mice by 17β-estradiol induces WISP-2/CCN5 expression in xenografts: A novel signaling molecule in hormonal carcinogenesis". Oncology Reports 13, no. 3 (2005): 445-448. https://doi.org/10.3892/or.13.3.445
Copy and paste a formatted citation
x
Spandidos Publications style
Ray G, Banerjee S, Saxena NK, Campbell DR, Van Veldhuizen P and Banerjee SK: Stimulation of MCF-7 tumor progression in athymic nude mice by 17β-estradiol induces WISP-2/CCN5 expression in xenografts: A novel signaling molecule in hormonal carcinogenesis. Oncol Rep 13: 445-448, 2005.
APA
Ray, G., Banerjee, S., Saxena, N.K., Campbell, D.R., Van Veldhuizen, P., & Banerjee, S.K. (2005). Stimulation of MCF-7 tumor progression in athymic nude mice by 17β-estradiol induces WISP-2/CCN5 expression in xenografts: A novel signaling molecule in hormonal carcinogenesis. Oncology Reports, 13, 445-448. https://doi.org/10.3892/or.13.3.445
MLA
Ray, G., Banerjee, S., Saxena, N. K., Campbell, D. R., Van Veldhuizen, P., Banerjee, S. K."Stimulation of MCF-7 tumor progression in athymic nude mice by 17β-estradiol induces WISP-2/CCN5 expression in xenografts: A novel signaling molecule in hormonal carcinogenesis". Oncology Reports 13.3 (2005): 445-448.
Chicago
Ray, G., Banerjee, S., Saxena, N. K., Campbell, D. R., Van Veldhuizen, P., Banerjee, S. K."Stimulation of MCF-7 tumor progression in athymic nude mice by 17β-estradiol induces WISP-2/CCN5 expression in xenografts: A novel signaling molecule in hormonal carcinogenesis". Oncology Reports 13, no. 3 (2005): 445-448. https://doi.org/10.3892/or.13.3.445
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