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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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March 2005 Volume 13 Issue 3

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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International Journal of Epigenetics

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Article

Genes associated with the genesis of leiomyoma of the uterus in a commonly deleted chromosomal region at 7q22

  • Authors:
    • Emi Saito
    • Aikou Okamoto
    • Misato Saito
    • Hideo Shinozaki
    • Satoshi Takakura
    • Nozomu Yanaihara
    • Kazunori Ochiai
    • Tadao Tanaka

  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, The Jikei University School of Medicine, 3-25-8 Nishi-Shinbashi, Minato-ku, Tokyo 105-8461, Japan
  • Pages: 469-472
    |
    Published online on: March 1, 2005
       https://doi.org/10.3892/or.13.3.469
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Abstract

Uterine leiomyoma occurs in about 20-30% of women over the age of 30, and is the most frequent benign tumor in gynecology. Despite its benign status, leiomyoma of the uterus has been reported to involve chromosomal abnormalities on chromosome 7. To search for genes associated with the genesis and development of this disease, we examined microsatellite alterations on chromosome 7 in 41 uterine leiomyomas, and identified a commonly-deleted region. Allelic imbalance on chromosome 7 was detected with an incidence of 7% (3/41), with the D7S501 locus being the most frequently affected (13%). The commonly deleted region was between D7S2545 and D7S2420. We examined alterations in the expression of genes located within this region by RT-PCR. Only the LAMB1 (Laminin β1) gene showed a variable expression. Of the 21 cases, 12 showed an increase, and 5 (24%) a decrease in the expression of LAMB1 in the leiomyomatous region. These results suggested that alteration of LAMB1 expression is associated with the genesis and development of uterine leiomyoma.

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Copy and paste a formatted citation
Spandidos Publications style
Saito E, Okamoto A, Saito M, Shinozaki H, Takakura S, Yanaihara N, Ochiai K and Tanaka T: Genes associated with the genesis of leiomyoma of the uterus in a commonly deleted chromosomal region at 7q22. Oncol Rep 13: 469-472, 2005.
APA
Saito, E., Okamoto, A., Saito, M., Shinozaki, H., Takakura, S., Yanaihara, N. ... Tanaka, T. (2005). Genes associated with the genesis of leiomyoma of the uterus in a commonly deleted chromosomal region at 7q22. Oncology Reports, 13, 469-472. https://doi.org/10.3892/or.13.3.469
MLA
Saito, E., Okamoto, A., Saito, M., Shinozaki, H., Takakura, S., Yanaihara, N., Ochiai, K., Tanaka, T."Genes associated with the genesis of leiomyoma of the uterus in a commonly deleted chromosomal region at 7q22". Oncology Reports 13.3 (2005): 469-472.
Chicago
Saito, E., Okamoto, A., Saito, M., Shinozaki, H., Takakura, S., Yanaihara, N., Ochiai, K., Tanaka, T."Genes associated with the genesis of leiomyoma of the uterus in a commonly deleted chromosomal region at 7q22". Oncology Reports 13, no. 3 (2005): 469-472. https://doi.org/10.3892/or.13.3.469
Copy and paste a formatted citation
x
Spandidos Publications style
Saito E, Okamoto A, Saito M, Shinozaki H, Takakura S, Yanaihara N, Ochiai K and Tanaka T: Genes associated with the genesis of leiomyoma of the uterus in a commonly deleted chromosomal region at 7q22. Oncol Rep 13: 469-472, 2005.
APA
Saito, E., Okamoto, A., Saito, M., Shinozaki, H., Takakura, S., Yanaihara, N. ... Tanaka, T. (2005). Genes associated with the genesis of leiomyoma of the uterus in a commonly deleted chromosomal region at 7q22. Oncology Reports, 13, 469-472. https://doi.org/10.3892/or.13.3.469
MLA
Saito, E., Okamoto, A., Saito, M., Shinozaki, H., Takakura, S., Yanaihara, N., Ochiai, K., Tanaka, T."Genes associated with the genesis of leiomyoma of the uterus in a commonly deleted chromosomal region at 7q22". Oncology Reports 13.3 (2005): 469-472.
Chicago
Saito, E., Okamoto, A., Saito, M., Shinozaki, H., Takakura, S., Yanaihara, N., Ochiai, K., Tanaka, T."Genes associated with the genesis of leiomyoma of the uterus in a commonly deleted chromosomal region at 7q22". Oncology Reports 13, no. 3 (2005): 469-472. https://doi.org/10.3892/or.13.3.469
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