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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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March 2005 Volume 13 Issue 3

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

Primary carcinoid tumor of the common hepatic duct: A rare case with immunohistochemical and molecular findings

  • Authors:
    • Saverio Ligato
    • Wieslaw Furmaga
    • Richard W. Cartun
    • David Hull
    • Gregory J. Tsongalis

  • View Affiliations / Copyright

    Affiliations: Department of Pathology and Laboratory Medicine, Hartford Hospital, Hartford, CT, USA
  • Pages: 543-546
    |
    Published online on: March 1, 2005
       https://doi.org/10.3892/or.13.3.543
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Abstract

We report immunohistochemical (IHC) and molecular findings in a rare case of a carcinoid tumor of the extrahepatic bile ducts in a 33-year-old woman, who presented with a 3.9x2.8x2.6 cm mass within the right and common hepatic ducts. She underwent surgery and a carcinoid tumor was identified. This lesion is of interest because in addition to the morphological and cytological features of a typical carcinoid, it demonstrated a distinct pleomorphic area immunoreactive for gastrin. By molecular analysis, loss of heterozygosity (LOH) with opposite allelic patterns between the gastrin-positive and gastrin-negative areas of the tumor was identified. The molecular studies for LOH along with the morphology and IHC profiling suggest that this second population of gastrin-positive carcinoid cells may represent a new clone within the carcinoid tumor with differentiation toward gastrin production or may represent the next step in the carcinogenic process with a gradual emergence of a more aggressive clone.

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Copy and paste a formatted citation
Spandidos Publications style
Ligato S, Furmaga W, Cartun RW, Hull D and Tsongalis GJ: Primary carcinoid tumor of the common hepatic duct: A rare case with immunohistochemical and molecular findings. Oncol Rep 13: 543-546, 2005.
APA
Ligato, S., Furmaga, W., Cartun, R.W., Hull, D., & Tsongalis, G.J. (2005). Primary carcinoid tumor of the common hepatic duct: A rare case with immunohistochemical and molecular findings. Oncology Reports, 13, 543-546. https://doi.org/10.3892/or.13.3.543
MLA
Ligato, S., Furmaga, W., Cartun, R. W., Hull, D., Tsongalis, G. J."Primary carcinoid tumor of the common hepatic duct: A rare case with immunohistochemical and molecular findings". Oncology Reports 13.3 (2005): 543-546.
Chicago
Ligato, S., Furmaga, W., Cartun, R. W., Hull, D., Tsongalis, G. J."Primary carcinoid tumor of the common hepatic duct: A rare case with immunohistochemical and molecular findings". Oncology Reports 13, no. 3 (2005): 543-546. https://doi.org/10.3892/or.13.3.543
Copy and paste a formatted citation
x
Spandidos Publications style
Ligato S, Furmaga W, Cartun RW, Hull D and Tsongalis GJ: Primary carcinoid tumor of the common hepatic duct: A rare case with immunohistochemical and molecular findings. Oncol Rep 13: 543-546, 2005.
APA
Ligato, S., Furmaga, W., Cartun, R.W., Hull, D., & Tsongalis, G.J. (2005). Primary carcinoid tumor of the common hepatic duct: A rare case with immunohistochemical and molecular findings. Oncology Reports, 13, 543-546. https://doi.org/10.3892/or.13.3.543
MLA
Ligato, S., Furmaga, W., Cartun, R. W., Hull, D., Tsongalis, G. J."Primary carcinoid tumor of the common hepatic duct: A rare case with immunohistochemical and molecular findings". Oncology Reports 13.3 (2005): 543-546.
Chicago
Ligato, S., Furmaga, W., Cartun, R. W., Hull, D., Tsongalis, G. J."Primary carcinoid tumor of the common hepatic duct: A rare case with immunohistochemical and molecular findings". Oncology Reports 13, no. 3 (2005): 543-546. https://doi.org/10.3892/or.13.3.543
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