Primary carcinoid tumor of the common hepatic duct: A rare case with immunohistochemical and molecular findings

  • Authors:
    • Saverio Ligato
    • Wieslaw Furmaga
    • Richard W. Cartun
    • David Hull
    • Gregory J. Tsongalis
  • View Affiliations

  • Published online on: March 1, 2005     https://doi.org/10.3892/or.13.3.543
  • Pages: 543-546
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Abstract

We report immunohistochemical (IHC) and molecular findings in a rare case of a carcinoid tumor of the extrahepatic bile ducts in a 33-year-old woman, who presented with a 3.9x2.8x2.6 cm mass within the right and common hepatic ducts. She underwent surgery and a carcinoid tumor was identified. This lesion is of interest because in addition to the morphological and cytological features of a typical carcinoid, it demonstrated a distinct pleomorphic area immunoreactive for gastrin. By molecular analysis, loss of heterozygosity (LOH) with opposite allelic patterns between the gastrin-positive and gastrin-negative areas of the tumor was identified. The molecular studies for LOH along with the morphology and IHC profiling suggest that this second population of gastrin-positive carcinoid cells may represent a new clone within the carcinoid tumor with differentiation toward gastrin production or may represent the next step in the carcinogenic process with a gradual emergence of a more aggressive clone.

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March 2005
Volume 13 Issue 3

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Ligato S, Furmaga W, Cartun RW, Hull D and Tsongalis GJ: Primary carcinoid tumor of the common hepatic duct: A rare case with immunohistochemical and molecular findings. Oncol Rep 13: 543-546, 2005
APA
Ligato, S., Furmaga, W., Cartun, R.W., Hull, D., & Tsongalis, G.J. (2005). Primary carcinoid tumor of the common hepatic duct: A rare case with immunohistochemical and molecular findings. Oncology Reports, 13, 543-546. https://doi.org/10.3892/or.13.3.543
MLA
Ligato, S., Furmaga, W., Cartun, R. W., Hull, D., Tsongalis, G. J."Primary carcinoid tumor of the common hepatic duct: A rare case with immunohistochemical and molecular findings". Oncology Reports 13.3 (2005): 543-546.
Chicago
Ligato, S., Furmaga, W., Cartun, R. W., Hull, D., Tsongalis, G. J."Primary carcinoid tumor of the common hepatic duct: A rare case with immunohistochemical and molecular findings". Oncology Reports 13, no. 3 (2005): 543-546. https://doi.org/10.3892/or.13.3.543