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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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April 2005 Volume 13 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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April 2005 Volume 13 Issue 4

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Article

Expression of c-kit (CD117) in neuroendocrine tumours - a target for therapy?

  • Authors:
    • Virginia Kostoula
    • Korsa Khan
    • Kay Savage
    • Mark Stubbs
    • Alberto Quaglia
    • Amar P. Dhillon
    • Daniel Hochhauser
    • Martyn E. Caplin

  • View Affiliations / Copyright

    Affiliations: Department of Medicine, Royal Free Hospital, Pond Street, London, NW3 2QG, UK
  • Pages: 643-647
    |
    Published online on: April 1, 2005
       https://doi.org/10.3892/or.13.4.643
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Abstract

c-kit is a tyrosine kinase receptor which is expressed in a wide variety of tumour cells such as gastrointestinal stromal tumours (GISTs), germ cell tumours, malignant trans-formation of mast cells, breast adenocarcinomas, malignant melanomas and small cell lung cancers. Imatinib mesylate is a tyrosine kinase inhibitor initially developed against the bcr-abl fusion protein of CML, but also shows therapeutic inhibitory activity against c-kit expressed in GISTs. Treatment of patients with neuroendocrine tumours (NETs) at present is limited. Our aim was to test NETs for c-kit expression and hence identify patients for the consideration of therapy with imatinib mesylate. NET patient specimens (n=85) were assessed for expression of c-kit proto-oncogene (CD117) by immunohistochemistry using two antibodies, a polyclonal antibody and a monoclonal. Of the samples 24% stained positive with the polyclonal antibody and 64% with the monoclonal antibody. This study highlights problems related to screening using c-kit antibodies for immunocyto-chemistry. It is possible that the polyclonal antibody is less specific. Studies need to be per-formed to determine if c-kit expression by NETs can be translated into therapeutic benefit by agents such as imatinib mesylate.

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Copy and paste a formatted citation
Spandidos Publications style
Kostoula V, Khan K, Savage K, Stubbs M, Quaglia A, Dhillon AP, Hochhauser D and Caplin ME: Expression of c-kit (CD117) in neuroendocrine tumours - a target for therapy?. Oncol Rep 13: 643-647, 2005.
APA
Kostoula, V., Khan, K., Savage, K., Stubbs, M., Quaglia, A., Dhillon, A.P. ... Caplin, M.E. (2005). Expression of c-kit (CD117) in neuroendocrine tumours - a target for therapy?. Oncology Reports, 13, 643-647. https://doi.org/10.3892/or.13.4.643
MLA
Kostoula, V., Khan, K., Savage, K., Stubbs, M., Quaglia, A., Dhillon, A. P., Hochhauser, D., Caplin, M. E."Expression of c-kit (CD117) in neuroendocrine tumours - a target for therapy?". Oncology Reports 13.4 (2005): 643-647.
Chicago
Kostoula, V., Khan, K., Savage, K., Stubbs, M., Quaglia, A., Dhillon, A. P., Hochhauser, D., Caplin, M. E."Expression of c-kit (CD117) in neuroendocrine tumours - a target for therapy?". Oncology Reports 13, no. 4 (2005): 643-647. https://doi.org/10.3892/or.13.4.643
Copy and paste a formatted citation
x
Spandidos Publications style
Kostoula V, Khan K, Savage K, Stubbs M, Quaglia A, Dhillon AP, Hochhauser D and Caplin ME: Expression of c-kit (CD117) in neuroendocrine tumours - a target for therapy?. Oncol Rep 13: 643-647, 2005.
APA
Kostoula, V., Khan, K., Savage, K., Stubbs, M., Quaglia, A., Dhillon, A.P. ... Caplin, M.E. (2005). Expression of c-kit (CD117) in neuroendocrine tumours - a target for therapy?. Oncology Reports, 13, 643-647. https://doi.org/10.3892/or.13.4.643
MLA
Kostoula, V., Khan, K., Savage, K., Stubbs, M., Quaglia, A., Dhillon, A. P., Hochhauser, D., Caplin, M. E."Expression of c-kit (CD117) in neuroendocrine tumours - a target for therapy?". Oncology Reports 13.4 (2005): 643-647.
Chicago
Kostoula, V., Khan, K., Savage, K., Stubbs, M., Quaglia, A., Dhillon, A. P., Hochhauser, D., Caplin, M. E."Expression of c-kit (CD117) in neuroendocrine tumours - a target for therapy?". Oncology Reports 13, no. 4 (2005): 643-647. https://doi.org/10.3892/or.13.4.643
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