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Print ISSN: 1021-335X Online ISSN: 1791-2431
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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
April 2005 Volume 13 Issue 4

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Journal Metrics

Impact Factor: 3.9

CiteScore: 8.3

CiteScore Rank: Q1: #73/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Review

Aspirin, ibuprofen, and other non-steroidal anti-inflammatory drugs in cancer prevention: A critical review of non-selective COX-2 blockade (Review)

Randall E. Harris, Joanne Beebe-Donk, Hani Doss, Deborah Burr Doss
Pages: 559-583
Published online on: 01 April 2005

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Article

Rat soluble tumor-associated antigens inhibit chemically-induced mammary tumorigenesis in syngeneic rats

George Kossoy, Herzl Ben-Hur, Asher Elhayany, David F. Schneider, Itshak Zusman
Pages: 585-588
Published online on: 01 April 2005

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Article

Pharmacokinetics and adverse reactions of a new liposomal cisplatin (Lipoplatin): Phase I study

George P. Stathopoulos, Teni Boulikas, Maria Vougiouka, George Deliconstantinos, Sotirios Rigatos, Eleftheria Darli, Vasiliki Viliotou, John G. Stathopoulos
Pages: 589-595
Published online on: 01 April 2005

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Article

Expression of thymidine phosphorylase correlates with microvessel density in prostate cancer

Akira Kataoka, Takeshi Yuasa, Susumu Kageyama, Hideaki Iwaki, Kayoko Higuchi, Tsutomu Tanaka, Yusaku Okada, Tatsuhiro Yoshiki
Pages: 597-600
Published online on: 01 April 2005

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Article

Relationship between peroxisome proliferator-activated receptor-γ expression and differentiation of human esophageal squamous cell carcinoma

Takashi Takashima, Yasuhiro Fujiwara, Masaki Hamaguchi, Eiji Sasaki, Kazunari Tominaga, Toshio Watanabe, Nobuhide Oshitani, Kazuhide Higuchi, Tetsuo Arakawa
Pages: 601-606
Published online on: 01 April 2005

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Article

Changes of histological and biological features by serial passages in a human adenoid cystic carcinoma line transplantable in nude mice

Susumu Hashitani, Kazuma Noguchi, Yukiyo Manno, Kuniyasu Moridera, Kazuki Takaoka, Norihiko Nishimura, Hiromitsu Kishimoto, Kazunari Sakurai, Masahiro Urade
Pages: 607-612
Published online on: 01 April 2005

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Article

Expression of cell adhesion molecules and chemokine receptors: Angioinvasiveness in nasal NK/T-cell lymphoma

Angen Liu, Shin-ichi Nakatsuka, Woo-Ick Yang, Shizuo Kojya, Katsuyuki Aozasa
Pages: 613-620
Published online on: 01 April 2005

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Article

Thymidine phosphorylase expression and efficacy of adjuvant doxifluridine in advanced colorectal cancer patients

Shiro Hasegawa, Kazuhiro Seike, Keiji Koda, Nobuhiro Takiguchi, Kenji Oda, Rumiko Hasegawa, Masaru Miyazaki
Pages: 621-626
Published online on: 01 April 2005

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Article

Venous thromboembolism in colorectal cancer patients with central venous catheters for 5-FU infusion-based pharmacokinetic modulating chemotherapy

Reigetsu Yoshikawa, Hidenori Yanagi, Masafumi Noda, Hiroki Ikeuchi, Hiroki Nakano, Makoto Gega, Kiyoshi Tsukamoto, Tsutomu Oshima, Takashi Inoue, Yoshinori Fujiwara, Yasutsugu Shoji, Takatoshi Sakaki, Satoshi Higasa, Tomoko Hashimoto-Tamaoki, Takehira Yamamura
Pages: 627-632
Published online on: 01 April 2005

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Article

Detection of Her2/neu, c-MYC and ZNF217 gene amplification during breast cancer progression using fluorescence in situ hybridization

Masayuki Shimada, Johji Imura, Takazumi Kozaki, Takahiro Fujimori, Shuichi Asakawa, Nobuyoshi Shimizu, Ryuji Kawaguchi
Pages: 633-641
Published online on: 01 April 2005

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Article

Expression of c-kit (CD117) in neuroendocrine tumours - a target for therapy?

Virginia Kostoula, Korsa Khan, Kay Savage, Mark Stubbs, Alberto Quaglia, Amar P. Dhillon, Daniel Hochhauser, Martyn E. Caplin
Pages: 643-647
Published online on: 01 April 2005

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Article

Atypical lipomatous tumor with rare structural rearrangements involving chromosomes 8 and 12

Malin Nilsson, Henryk Domanski, Fredrik Mertens, Nils Mandahl
Pages: 649-652
Published online on: 01 April 2005

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Article

Antiproliferation effects of ponicidin on human myeloid leukemia cells in vitro

Jia-Jun Liu, Ren-Wei Huang, Dong-Jun Lin, Xiang-Yuan Wu, Qu Lin, Jun Peng, Xianglin Pan, Yu-Qin Song, Mao-hong Zhang, Ming Hou, Feng Chen
Pages: 653-657
Published online on: 01 April 2005

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Article

Inhibition of cell cycle and induction of apoptosis by sulforaphane in cell lines carrying various inherited BRCA1 mutations

Irena Misiewicz, Agata Kozar, Katarzyna Skupinska, Elzbieta Kowalska, Jan Lubinski, Teresa Kasprzycka-Guttman
Pages: 659-665
Published online on: 01 April 2005

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Article

Long-term administration of low-dose cisplatin plus 5-fluorouracil prolongs the postoperative survival of patients with esophageal cancer

Atsushi Shiozaki, Hisakazu Yamagishi, Hirosumi Itoi, Hitoshi Fujiwara, Shojiro Kikuchi, Kazuma Okamoto, Daisuke Ichikawa, Nobuaki Fuji, Toshiya Ochiai, Teruhisa Sonoyama, Yuji Ueda
Pages: 667-672
Published online on: 01 April 2005

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Article

Aberrant expression of HOX genes in human invasive breast carcinoma

Kokonoe Makiyama, Jun-ichi Hamada, Minoru Takada, Katsuhiko Murakawa, Yoko Takahashi, Mitsuhiro Tada, Eiji Tamoto, Gaku Shindo, Akihiro Matsunaga, Ken-ichi Teramoto, Kazuteru Komuro, Satoshi Kondo, Hiroyuki Katoh, Takao Koike, Tetsuya Moriuchi
Pages: 673-679
Published online on: 01 April 2005

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Article

Irinotecan combined or alternated with bolus 5-fluorouracil and folinic acid versus the Mayo Clinic regimen in the first-line therapy of advanced colorectal cancer

Ullrich Graeven, Karsten Ridwelski, Maja Artandi, Pilar Espana, Jürgen Schölmerich, Adolfo M. Rosales, Göran CARLSSON, Markus Borner, Blandine Boussard, Wolff Schmiegel
Pages: 681-688
Published online on: 01 April 2005

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Article

Pro-neoangiogenic cytokines (VEGF and bFGF) and anemia in solid tumor patients

Camillo Porta, Ilaria Imarisio, Mara De Amici, Lucia Bonomi, Chiara Paglino, Elisa Biscaldi, Matteo Zimatore, Andrea Sartore-Bianchi, Marco Danova, Remigio Moratti, Alberto Riccardi
Pages: 689-695
Published online on: 01 April 2005

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Article

Predictive value of COX-2 for the effect of chemoradiotherapy on esophageal squamous cell carcinoma

Hiroyuki Takatori, Shoji Natsugoe, Hiroshi Okumura, Masataka Matsumoto, Sumiya Ishigami, Tetsuhiro Owaki, Takashi Aikou
Pages: 697-701
Published online on: 01 April 2005

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Article

Infrequent mutation of the human envoplakin gene is closely linked to the tylosis oesophageal cancer locus in sporadic oesophageal squamous cell carcinomas

Takeshi Iwaya, Chihaya Maesawa, Toshimoto Kimura, Satoshi Ogasawara, Kenichro Ikeda, Yusuke Kimura, Yoshinori Noda, Kaoru Ishida, Nobuhiro Sato, Kazuyoshi Saito, Tomoyuki Masuda
Pages: 703-707
Published online on: 01 April 2005

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Article

Establishment and gene analysis of a cisplatin-resistant cell line, Sa-3R, derived from oral squamous cell carcinoma

Ken Nakatani, Megumi Nakamura, Katsuhiro Uzawa, Takeshi Wada, Naohiko Seki, Hideki Tanzawa, Shigeyuki Fujita
Pages: 709-714
Published online on: 01 April 2005

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Article

E1AF expression is closely correlated with malignant phenotype of tongue squamous cell carcinoma through activation of MT1-MMP gene promoters

Yuri Izumiyama, Yoichi Ohiro, Fumihiro Higashino, Koichi Yoshida, Kazunori Taguchi, Satoru Todo, Takao Kohgo, Yasunori Totsuka, Masanobu Shindoh
Pages: 715-720
Published online on: 01 April 2005

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Article

Regulation of tumor invasion by HOXB13 gene overexpressed in human endometrial cancer

YaWei Zhao, Tsuyoshi Yamashita, Mutsuo Ishikawa
Pages: 721-726
Published online on: 01 April 2005

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Article

The prognostic value of overexpression of Skp2 mRNA in non-small cell lung cancer

Iwao Takanami
Pages: 727-731
Published online on: 01 April 2005

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Article

Early diagnosis and monitoring of superficial transitional cell carcinoma by microsatellite analysis on urine sediment

Takashi Hachisuka, Michihiro Narikiyo, Yukishige Yamada, Hirofumi Ishikawa, Masato Ueno, Hideki Uchida, Ryo Yoriki, Yuichirou Ohigashi, Katsuhiko Miki, Hidetoshi Tamaki, Takashi Mizuno, Yoshiyuki Nakajima
Pages: 733-737
Published online on: 01 April 2005

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Article

Loss of heterozygosity in ductal lavage for breast tumor and the contralateral breast

Yasuhiro Yonekura, Daigo Yamamoto, Homa Okugawa, Kanji Tanaka, Yasuo Kamiyama
Pages: 739-743
Published online on: 01 April 2005

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Article

Role of extracellular matrix in regulation of staurosporine-induced apoptosis in breast cancer cells

F. Vasaturo, C. Malacrino, E. Sallusti, G. Coppotelli, P. Birarelli, A. Giuffrida, L. Albonici, L. Simonelli, A. Modesti, M. Modesti, S. Scarpa
Pages: 745-750
Published online on: 01 April 2005

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Article

PImmunotherapy of renal cell carcinoma with granulocyte macrophage colony stimulating factor and very low dose interleukin-2

Pierpaolo Correale, Stefania Marsili, Marianna Sabatino, Francesco Montagnani, Giorgio Giorgi, Guido Francini
Pages: 751-756
Published online on: 01 April 2005

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Article

Selection of tumor-targeting agents on freshly excised human breast tumors using a phage display library

Girja S. Shukla, David N. Krag
Pages: 757-764
Published online on: 01 April 2005

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Article

Human antibody SC-1 reduces disseminated tumor cells in nude mice with human gastric cancer

Bertram Illert, Christoph Otto, H. Peter Vollmers, Frank Hensel, Arnulf Thiede, Wolfgang Timmermann
Pages: 765-770
Published online on: 01 April 2005

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Article

Comparative genomics on Wnt16 orthologs

Yuriko Katoh, Masaru Katoh
Pages: 771-775
Published online on: 01 April 2005

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Article

Comparative genomics on Wnt7a orthologs

Masuko Katoh, Masaru Katoh
Pages: 777-780
Published online on: 01 April 2005

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Journal Cover
April-2026 Volume 55 Issue 4

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Journal Metrics

Impact Factor: 3.9

CiteScore: 8.3

CiteScore Rank: Q1: #73/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Article Open Access

KDM5D expression is lost in cisplatin‑resistant neuroblastoma cells

Natalia Podhorska, Jan Hrabeta, Marie Belhajova, Tomas Eckschlager
Article Number: 79
Published online on: 25 February 2026

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Article Open Access

Role of iron and TfR1 in the application of high‑dose ascorbate against pancreatic cancer

Alban Piotrowsky, Christian Leischner, Hendrik Schmieder, Katja Detert, Kathrin Schneider, Johanna Schulte, Sabrina Hammerschmidt, Luigi Marongiu, Olga Renner, Markus Burkard, Sascha Venturelli
Article Number: 78
Published online on: 24 February 2026

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Review Open Access

Advances in immunotherapy and targeted therapy for nasopharyngeal carcinoma: Current progress and combined approaches (Review)

Zhen Yang, Huajun Liu, Meilin Chen, Liming Zhang, Meiling Gong, Ruilian Yu
Article Number: 77
Published online on: 24 February 2026

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Retraction Open Access

[Retracted] Overexpression of SHP2 tyrosine phosphatase promotes the tumorigenesis of breast carcinoma

Zhongqian Hu, Haoshu Fang, Xinyi Wang, Danlei Chen, Zhuo Chen, Siying Wang
Article Number: 76
Published online on: 24 February 2026

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Article Open Access

NR4A1 mediates chemotherapy‑induced senescence via the PI3K/AKT pathway in gastric cancer cells

Tingyu Zhang, Yue Wang, Jiuna Zhang, Xueshuai Ye, Yanfeng Shen, Zhiwei Zhang
Article Number: 75
Published online on: 18 February 2026

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Article

Hypoxia‑induced miR‑135b‑5p promotes neuroendocrine differentiation of prostate cancer cells through HIF1AN‑HIF1α axis

Pampana Sandhya Venkata Lakshmi, Jagrati Parashar, Biswajit Biswas, Ramesh Ummanni
Article Number: 74
Published online on: 16 February 2026

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Retraction Open Access

[Retracted] Knockdown of human antigen R reduces the growth and invasion of breast cancer cells in vitro and affects expression of cyclin D1 and MMP‑9

Zhu Yuan, Andrew J. Sanders, Lin Ye, Yu Wang, Wen G. Jiang
Article Number: 73
Published online on: 16 February 2026

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Review Open Access

Liquid biopsy in malignant primary bone tumors: Clinical applications of circulating tumor DNA and circulating tumor cells for diagnosis, prognosis and treatment monitoring (Review)

Bin Tian, Xuesong Chen, Jiang Zheng, Xin Kang
Article Number: 72
Published online on: 12 February 2026

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Article Open Access

Tumor visualization and evaluation of glioblastoma in mice using small animal 9.4T MRI and PET‑CT with high resolution

Shuangyi Li, Wenjiao Gu, Ying Jiang, Ting Liu, Limei Shuai, Yujie Wei, Youming Shi, Havyarimana Juvenal, Zhimin Wang, Yucai Wei, Bofan Wu, Xiaochun Zhou, Yumin Li, Futian Tang
Article Number: 71
Published online on: 12 February 2026

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Expression of Concern Open Access

[Expression of Concern] Interference of STAT 5b expression enhances the chemo‑sensitivity of gastric cancer cells to gefitinib by promoting mitochondrial pathway‑mediated cell apoptosis

Tao Sun, Yanfei Jia, Dongjie Xiao
Article Number: 70
Published online on: 11 February 2026

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Article Open Access

Regorafenib and Nifuroxazide exert enhanced suppression of hepatocellular carcinoma by inhibiting STAT3 and immune remodeling

Kun Li, Jinwei Chen, Zhi Zheng, Yichun Gao, Jiayu Zhang, Wenya Ding, Tongguo Yang, Yuyang Gu, Xuhua Duan, Tiesuo Zhao, Huijie Jia, Pengfei Chen, Jianzhuang Ren
Article Number: 69
Published online on: 11 February 2026

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Article Open Access

Suppressive role of SCN4B in the epithelial‑mesenchymal transition of lung adenocarcinoma

Mengnan Guo, He Li, Zhifang Zhao, Yuanyuan Wang, Jiaqi Tang, Binghan Zhong, Yunxia Zhao
Article Number: 68
Published online on: 10 February 2026

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Retraction Open Access

[Retracted] miR‑218 suppresses cardiac myxoma proliferation by targeting myocyte enhancer factor 2D

Quanxing Cao, Pingshuan Dong, Yanyu Wang, Junwei Zhang, Xinge Shi, Yongsheng Wang
Article Number: 67
Published online on: 09 February 2026

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Review

Impact of the intratumoral resident microbiome on the immune microenvironment of malignant tumors (Review)

Han Na Oh, Hoon Hur
Article Number: 66
Published online on: 06 February 2026

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Correction Open Access

[Corrigendum] Hypoxia and macrophages promote glioblastoma invasion by the CCL4‑CCR5 axis

Ying Wang, Tao Liu, Ning Yang, Shuo Xu, Xingang Li, Donghai Wang
Article Number: 65
Published online on: 04 February 2026

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Review Open Access

Origin dictates function: The dual roles of exosomes derived from diverse origins in the onset and progression of colorectal cancer (Review)

Zhao Guo, Haoyan Zhuang, Qingfeng Liu
Article Number: 64
Published online on: 03 February 2026

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Article Open Access

Quercetin reduces expression of ATP‑binding cassette transporters by regulating the PTEN/PI3K/AKT signaling pathway in breast cancer cells

Wentao Fu, Leying Lin, Jie Li, Fei Qin, Chuan Chen, Yinglian Cai, Yilun Cai, Yiling Huang, Wang Yang, Shanshan Zhu
Article Number: 63
Published online on: 02 February 2026

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Article Open Access

POSTN+ fibroblast‑secreted small extracellular vesicles drive macrophage M2 polarization through BMP4/BMPR2/Smad signaling

Chenyang Zhang, Si Chen, Chenghui Qian, Wanqi Lv, Qian Zhang, Yanjin Wang, Yuqiong Wu, Xue Liu
Article Number: 62
Published online on: 02 February 2026

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Retraction Open Access

[Retracted] EGFR/HER2 inhibitors effectively reduce the malignant potential of MDR breast cancer evoked by P‑gp substrates in vitro and in vivo

Yiting Jin, Wei Zhang, Hongying Wang, Zijing Zhang, Chengyu Chu, Xiuping Liu, Qiang Zou
Article Number: 61
Published online on: 02 February 2026

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Article

Tumor‑associated glucocorticoid inhibition by mifepristone reduces polymorphonuclear myeloid‑derived suppressor cells and promotes antitumor immunity in triple‑negative breast cancer‑bearing mice

Masato Kobayashi, Chisana Konno, Ayato Shimizu, Masanori Kobayashi, Tatsuya Hori
Article Number: 60
Published online on: 30 January 2026

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Review Open Access

Mitochondria in T‑cell tumor immunity and tumor therapies targeting mitochondria (Review)

Minjie Zhou, Yijie Xie, Zhipeng Liu, Yi He, Yibing Yin, Keyu Chen, Zhengyu Zhao, Chengshun Zhang, Dingjun Cai
Article Number: 59
Published online on: 29 January 2026

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Article Open Access

TRIM46 deficiency‑induced DNA damage enhances the sensitivity of cisplatin in non‑small cell lung cancer by regulating the Akt signaling pathway

Song Jin, Dandan Zhang, Zhicheng Liao, Lingpei Yu, Yuanyuan Wang, Pengcheng Jia, Minmin Pan, Yifan Li, Jizhou Zhang
Article Number: 58
Published online on: 28 January 2026

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Review Open Access

Advances in isolation and detection technologies and immunotherapy applications of circulating tumor cells (Review)

Ping Zhou, Qin Ye, Yiyun Huang, Yumei Feng, Li Zhou, Ke Xie
Article Number: 57
Published online on: 28 January 2026

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Correction Open Access

[Corrigendum] 3‑Bromopyruvate sensitizes human breast cancer cells to TRAIL‑induced apoptosis via the phosphorylated AMPK‑mediated upregulation of DR5

Yuzhong Chen, Li Wei, Xiaojing Zhang, Xianfu Liu, Yansong Chen, Song Zhang, Lanzhu Zhou, Qixiang Li, Qiong Pan, Surong Zhao, Hao Liu
Article Number: 56
Published online on: 28 January 2026

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Article Open Access

High RMI1 expression is associated with cancer cell progression and poor prognosis in prostate cancer

Pengliang Shen, Xiaosong Wang, Xiaoting Yan, Hongyang Du, Bo Wu, Xiaoming Cao
Article Number: 55
Published online on: 27 January 2026

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Retraction Open Access

[Retracted] MicroRNA‑615‑5p targets insulin‑like growth factor 2 and exerts tumor‑suppressing functions in human esophageal squamous cell carcinoma

Bingyin Yang, Rui Xie, Shang-Nong Wu, Cheng-Cheng Gao, Xiao-Zhong Yang, Jing-Fang Zhou
Article Number: 54
Published online on: 26 January 2026

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May-2026 Volume 55 Issue 5

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Impact Factor: 3.9

CiteScore: 8.3

CiteScore Rank: Q1: #73/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Article Open Access

Cellular and inflammatory characteristics of patient‑derived glioblastoma organoids during in vitro cultivation

Jessica Nojszewski, Nils Oliver Schröder, Jacqueline Clüver, Jonna Holler, Hajrullah Ahmeti, Michael Synowitz, Janka Held‑Feindt
Article Number: 85
Published online on: 02 March 2026

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[Retracted] Growth and differentiation factor‑9 promotes adhesive and motile capacity of prostate cancer cells by up‑regulating FAK and Paxillin via Smad dependent pathway 

Sivan M. Bokobza, Lin Ye, Howard G. Kynaston, Wen G. Jiang
Article Number: 84
Published online on: 02 March 2026

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Platycodin D sensitizes head and neck squamous cell carcinoma to cisplatin by inducing autophagy arrest

Minji Bae, Min Kyeong Lee, Mi Gyeong Jeong, Yeonseo Lee, Harim Joo, Young Chan Lee, Jung Woo Lee, Su Il Kim, Seong-Gyu Ko, Young-Gyu Eun
Article Number: 83
Published online on: 27 February 2026

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ACSBG1‑driven lipid reprogramming unveiled: A fatty acid metabolism‑associated prognostic model for lung adenocarcinoma

Panxin Hu, Anan Li
Article Number: 82
Published online on: 27 February 2026

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Article Open Access

Knockdown of CCT2 inhibits the malignant progression of hepatocellular carcinoma cells by impairing STAT3 activation

Chao Li, Lei Yang, Yudong Zhang, Baocheng Zhao, Hao Qu
Article Number: 81
Published online on: 25 February 2026

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Retraction Open Access

[Retracted] Songorine suppresses cell growth and metastasis in epithelial ovarian cancer via the Bcl‑2/Bax and GSK3β/β‑catenin signaling pathways

Hongxia Zhang, Ruifeng Dong, Ping Zhang, Yankui Wang
Article Number: 80
Published online on: 25 February 2026

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