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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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April 2005 Volume 13 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

Inhibition of cell cycle and induction of apoptosis by sulforaphane in cell lines carrying various inherited BRCA1 mutations

  • Authors:
    • Irena Misiewicz
    • Agata Kozar
    • Katarzyna Skupinska
    • Elzbieta Kowalska
    • Jan Lubinski
    • Teresa Kasprzycka-Guttman

  • View Affiliations / Copyright

    Affiliations: Confocal Microscopy Laboratory, National Institute of Public Health, Chelmska 30/34, 00-725 Warsaw, Poland. guttman@il.waw.pl
  • Pages: 659-665
    |
    Published online on: April 1, 2005
       https://doi.org/10.3892/or.13.4.659
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Abstract

The important aspect of sulforaphane (SFN) chemopreventive activity is its ability to induce cell growth inhibition and apoptosis. In this study, the effect of SFN on lymphoblastoid cells derived from people carrying four different germ-line mutations in BRCA1 gene was tested and compared to the effect of SFN on wild-type cells. The mutations studied were C61G, 3819del5, 4153delA and 5382INSC. Changes in cell viability and density after SFN treatment were evaluated, as well as cell cycle progression, changes in mitochondrial membrane potential, and phosphatidylserine externalization. SFN was shown to reduce cell viability and density in all cell lines tested. Cell cycle block in S-phase and the occurence of simultaneous apoptosis were observed. The concentration of SFN needed to elicit a comparable effect on each cell line was varied. We found that the effect of SFN on cells carrying different inherited mutations depended on mutation type.

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Copy and paste a formatted citation
Spandidos Publications style
Misiewicz I, Kozar A, Skupinska K, Kowalska E, Lubinski J and Kasprzycka-Guttman T: Inhibition of cell cycle and induction of apoptosis by sulforaphane in cell lines carrying various inherited BRCA1 mutations. Oncol Rep 13: 659-665, 2005.
APA
Misiewicz, I., Kozar, A., Skupinska, K., Kowalska, E., Lubinski, J., & Kasprzycka-Guttman, T. (2005). Inhibition of cell cycle and induction of apoptosis by sulforaphane in cell lines carrying various inherited BRCA1 mutations. Oncology Reports, 13, 659-665. https://doi.org/10.3892/or.13.4.659
MLA
Misiewicz, I., Kozar, A., Skupinska, K., Kowalska, E., Lubinski, J., Kasprzycka-Guttman, T."Inhibition of cell cycle and induction of apoptosis by sulforaphane in cell lines carrying various inherited BRCA1 mutations". Oncology Reports 13.4 (2005): 659-665.
Chicago
Misiewicz, I., Kozar, A., Skupinska, K., Kowalska, E., Lubinski, J., Kasprzycka-Guttman, T."Inhibition of cell cycle and induction of apoptosis by sulforaphane in cell lines carrying various inherited BRCA1 mutations". Oncology Reports 13, no. 4 (2005): 659-665. https://doi.org/10.3892/or.13.4.659
Copy and paste a formatted citation
x
Spandidos Publications style
Misiewicz I, Kozar A, Skupinska K, Kowalska E, Lubinski J and Kasprzycka-Guttman T: Inhibition of cell cycle and induction of apoptosis by sulforaphane in cell lines carrying various inherited BRCA1 mutations. Oncol Rep 13: 659-665, 2005.
APA
Misiewicz, I., Kozar, A., Skupinska, K., Kowalska, E., Lubinski, J., & Kasprzycka-Guttman, T. (2005). Inhibition of cell cycle and induction of apoptosis by sulforaphane in cell lines carrying various inherited BRCA1 mutations. Oncology Reports, 13, 659-665. https://doi.org/10.3892/or.13.4.659
MLA
Misiewicz, I., Kozar, A., Skupinska, K., Kowalska, E., Lubinski, J., Kasprzycka-Guttman, T."Inhibition of cell cycle and induction of apoptosis by sulforaphane in cell lines carrying various inherited BRCA1 mutations". Oncology Reports 13.4 (2005): 659-665.
Chicago
Misiewicz, I., Kozar, A., Skupinska, K., Kowalska, E., Lubinski, J., Kasprzycka-Guttman, T."Inhibition of cell cycle and induction of apoptosis by sulforaphane in cell lines carrying various inherited BRCA1 mutations". Oncology Reports 13, no. 4 (2005): 659-665. https://doi.org/10.3892/or.13.4.659
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