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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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May 2005 Volume 13 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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May 2005 Volume 13 Issue 5

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Article

Immunological evaluation of personalized peptide vaccination for patients with pancreatic cancer

  • Authors:
    • Koutaro Yamamoto
    • Takashi Mine
    • Kazuko Katagiri
    • Nobuaki Suzuki
    • Toru Kawaoka
    • Tomio Ueno
    • Satoko Matsueda
    • Akira Yamada
    • Kyogo Itoh
    • Hideaki Yamana
    • Masaaki Oka
  • View Affiliations / Copyright

    Affiliations: Department of Digestive Surgery and Surgical Oncology (Surgery II), Yamaguchi University School of Medicine, 1-1-1 Minamiogushi, Ube 755-8505, Japan
  • Pages: 874-883
    |
    Published online on: May 1, 2005
       https://doi.org/10.3892/or.13.5.874
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Abstract

The prognosis of pancreatic cancer is extremely poor, and development of new treatment modalities is needed. One such treatment could be specific immunotherapy. To evaluate safety and immunological responses, we conducted a phase I study of personalized peptide vaccination for pancreatic cancer patients (n=11). Namely, pre-vaccination peripheral blood mononuclear cells were screened for their reactivity in vitro to each of 14 or 16 peptides in HLA-A24+ or -A2+ patients, and only the reactive peptides (maximum: 4) were vaccinated in vivo. This regimen was generally well tolerated, although inflammatory reactions at the injection site were observed in 7 patients. Delayed-type hypersensitivity to peptides used for vaccination was observed in 7 patients. Increased cellular and humoral immune responses to at least one of peptides used for vaccination were observed in the post-vaccination PBMCs and sera from 4 of 8 patients and 4 of 10 patients tested, respectively. The 6- and 12-month survival rates for patients who received >3 vaccinations (n=10) were 80% and 20%, respectively. Due to tolerability and capability of inducing specific immunity, further development of personalized peptide-based immunotherapy for pancreatic cancer patients is warranted.

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Copy and paste a formatted citation
Spandidos Publications style
Yamamoto K, Mine T, Katagiri K, Suzuki N, Kawaoka T, Ueno T, Matsueda S, Yamada A, Itoh K, Yamana H, Yamana H, et al: Immunological evaluation of personalized peptide vaccination for patients with pancreatic cancer. Oncol Rep 13: 874-883, 2005.
APA
Yamamoto, K., Mine, T., Katagiri, K., Suzuki, N., Kawaoka, T., Ueno, T. ... Oka, M. (2005). Immunological evaluation of personalized peptide vaccination for patients with pancreatic cancer. Oncology Reports, 13, 874-883. https://doi.org/10.3892/or.13.5.874
MLA
Yamamoto, K., Mine, T., Katagiri, K., Suzuki, N., Kawaoka, T., Ueno, T., Matsueda, S., Yamada, A., Itoh, K., Yamana, H., Oka, M."Immunological evaluation of personalized peptide vaccination for patients with pancreatic cancer". Oncology Reports 13.5 (2005): 874-883.
Chicago
Yamamoto, K., Mine, T., Katagiri, K., Suzuki, N., Kawaoka, T., Ueno, T., Matsueda, S., Yamada, A., Itoh, K., Yamana, H., Oka, M."Immunological evaluation of personalized peptide vaccination for patients with pancreatic cancer". Oncology Reports 13, no. 5 (2005): 874-883. https://doi.org/10.3892/or.13.5.874
Copy and paste a formatted citation
x
Spandidos Publications style
Yamamoto K, Mine T, Katagiri K, Suzuki N, Kawaoka T, Ueno T, Matsueda S, Yamada A, Itoh K, Yamana H, Yamana H, et al: Immunological evaluation of personalized peptide vaccination for patients with pancreatic cancer. Oncol Rep 13: 874-883, 2005.
APA
Yamamoto, K., Mine, T., Katagiri, K., Suzuki, N., Kawaoka, T., Ueno, T. ... Oka, M. (2005). Immunological evaluation of personalized peptide vaccination for patients with pancreatic cancer. Oncology Reports, 13, 874-883. https://doi.org/10.3892/or.13.5.874
MLA
Yamamoto, K., Mine, T., Katagiri, K., Suzuki, N., Kawaoka, T., Ueno, T., Matsueda, S., Yamada, A., Itoh, K., Yamana, H., Oka, M."Immunological evaluation of personalized peptide vaccination for patients with pancreatic cancer". Oncology Reports 13.5 (2005): 874-883.
Chicago
Yamamoto, K., Mine, T., Katagiri, K., Suzuki, N., Kawaoka, T., Ueno, T., Matsueda, S., Yamada, A., Itoh, K., Yamana, H., Oka, M."Immunological evaluation of personalized peptide vaccination for patients with pancreatic cancer". Oncology Reports 13, no. 5 (2005): 874-883. https://doi.org/10.3892/or.13.5.874
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