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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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June 2005 Volume 13 Issue 6

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

A multicellular spheroid-based drug sensitivity test by scanning electrochemical microscopy

  • Authors:
    • Yu-suke Torisawa
    • Airi Takagi
    • Hitoshi Shiku
    • Tomoyuki Yasukawa
    • Tomokazu Matsue

  • View Affiliations / Copyright

    Affiliations: Graduate School of Environmental Studies, Tohoku University, Sendai 980-8579, Japan
  • Pages: 1107-1112
    |
    Published online on: June 1, 2005
       https://doi.org/10.3892/or.13.6.1107
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Abstract

The respiratory activity of a multicellular spheroid was non-invasively monitored by scanning electrochemical microscopy (SECM) to investigate the anticancer drug sensitivity. The effects of the three anticancer drugs, cisplatin (CDDP), 5-fluorouracil (5-FU), and paclitaxel (TXL), were continuously evaluated based on respiratory activity for 5 days. The drug sensitivities obtained by SECM were higher compared to those evaluated by the spheroid volume and conformed to those evaluated by a conventional colorimetric assay. Our results show that the SECM-based assay directly correlates with the number of viable cells within the spheroid, whereas the spheroid volume does not necessarily correlate with the number of viable cells. Furthermore, the results obtained by spheroid culture (3-D) were compared to those of cells cultured in a flask (2-D) and within a collagen gel (3-D). The drug sensitivity of cells cultured in 2-D is more pronounced than that of the cells cultured in 3-D. Since the cellular proliferation status in a 3-D culture is similar to that in vivo, the drug sensitivity test performed in the spheroid culture will give meaningful results that can be extended to an in vivo application. A SECM-based assay is perfectly suitable to directly evaluate the drug sensitivity of the spheroid.

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Copy and paste a formatted citation
Spandidos Publications style
Torisawa Y, Takagi A, Shiku H, Yasukawa T and Matsue T: A multicellular spheroid-based drug sensitivity test by scanning electrochemical microscopy. Oncol Rep 13: 1107-1112, 2005.
APA
Torisawa, Y., Takagi, A., Shiku, H., Yasukawa, T., & Matsue, T. (2005). A multicellular spheroid-based drug sensitivity test by scanning electrochemical microscopy. Oncology Reports, 13, 1107-1112. https://doi.org/10.3892/or.13.6.1107
MLA
Torisawa, Y., Takagi, A., Shiku, H., Yasukawa, T., Matsue, T."A multicellular spheroid-based drug sensitivity test by scanning electrochemical microscopy". Oncology Reports 13.6 (2005): 1107-1112.
Chicago
Torisawa, Y., Takagi, A., Shiku, H., Yasukawa, T., Matsue, T."A multicellular spheroid-based drug sensitivity test by scanning electrochemical microscopy". Oncology Reports 13, no. 6 (2005): 1107-1112. https://doi.org/10.3892/or.13.6.1107
Copy and paste a formatted citation
x
Spandidos Publications style
Torisawa Y, Takagi A, Shiku H, Yasukawa T and Matsue T: A multicellular spheroid-based drug sensitivity test by scanning electrochemical microscopy. Oncol Rep 13: 1107-1112, 2005.
APA
Torisawa, Y., Takagi, A., Shiku, H., Yasukawa, T., & Matsue, T. (2005). A multicellular spheroid-based drug sensitivity test by scanning electrochemical microscopy. Oncology Reports, 13, 1107-1112. https://doi.org/10.3892/or.13.6.1107
MLA
Torisawa, Y., Takagi, A., Shiku, H., Yasukawa, T., Matsue, T."A multicellular spheroid-based drug sensitivity test by scanning electrochemical microscopy". Oncology Reports 13.6 (2005): 1107-1112.
Chicago
Torisawa, Y., Takagi, A., Shiku, H., Yasukawa, T., Matsue, T."A multicellular spheroid-based drug sensitivity test by scanning electrochemical microscopy". Oncology Reports 13, no. 6 (2005): 1107-1112. https://doi.org/10.3892/or.13.6.1107
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