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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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July 2005 Volume 14 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Medicine International

An International Open Access Journal Devoted to General Medicine.

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Review

Urokinase-type plasminogen activator system and breast cancer (Review)

  • Authors:
    • Bo Han
    • Misa Nakamura
    • Ichiro Mori
    • Yasushi Nakamura
    • Kennichi Kakudo

  • View Affiliations / Copyright

    Affiliations: Department of Pathology, Wakayama Medical University, Kimiidera 811-1, Wakayama 641-8509, Japan
  • Pages: 105-112
    |
    Published online on: July 1, 2005
       https://doi.org/10.3892/or.14.1.105
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Abstract

Malignant tumors have a capacity to degrade the extracellular matrix (ECM) by controlled proteolysis. One proteolytic system involved in these processes is the urokinase-type plasminogen activator (uPA) system, which consists of uPA, uPA receptor (uPAR) and uPA inhibitors 1 and 2 (PAI-1 and PAI-2). In the past two decades, study of the uPA system in human breast cancer has yielded valuable insights. Increased levels of uPA, PAI-1 and uPAR have been reported to be associated with poor prognosis in patients with breast cancer. Furthermore, uPA and PAI-1 may be new prognostic markers for axillary node-negative patients. To date, a growing body of evidence has suggested that uPA system promotes tumor metastasis by several different mechanisms, not just by breaking down the ECM. This article is focused on reviewing the current understanding of uPA system members as prognostic markers in breast cancer, and their cellular localization and tissue distribution. Correlations of the uPA system with other informative markers of breast cancer are also discussed.

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Copy and paste a formatted citation
Spandidos Publications style
Han B, Nakamura M, Mori I, Nakamura Y and Kakudo K: Urokinase-type plasminogen activator system and breast cancer (Review). Oncol Rep 14: 105-112, 2005.
APA
Han, B., Nakamura, M., Mori, I., Nakamura, Y., & Kakudo, K. (2005). Urokinase-type plasminogen activator system and breast cancer (Review). Oncology Reports, 14, 105-112. https://doi.org/10.3892/or.14.1.105
MLA
Han, B., Nakamura, M., Mori, I., Nakamura, Y., Kakudo, K."Urokinase-type plasminogen activator system and breast cancer (Review)". Oncology Reports 14.1 (2005): 105-112.
Chicago
Han, B., Nakamura, M., Mori, I., Nakamura, Y., Kakudo, K."Urokinase-type plasminogen activator system and breast cancer (Review)". Oncology Reports 14, no. 1 (2005): 105-112. https://doi.org/10.3892/or.14.1.105
Copy and paste a formatted citation
x
Spandidos Publications style
Han B, Nakamura M, Mori I, Nakamura Y and Kakudo K: Urokinase-type plasminogen activator system and breast cancer (Review). Oncol Rep 14: 105-112, 2005.
APA
Han, B., Nakamura, M., Mori, I., Nakamura, Y., & Kakudo, K. (2005). Urokinase-type plasminogen activator system and breast cancer (Review). Oncology Reports, 14, 105-112. https://doi.org/10.3892/or.14.1.105
MLA
Han, B., Nakamura, M., Mori, I., Nakamura, Y., Kakudo, K."Urokinase-type plasminogen activator system and breast cancer (Review)". Oncology Reports 14.1 (2005): 105-112.
Chicago
Han, B., Nakamura, M., Mori, I., Nakamura, Y., Kakudo, K."Urokinase-type plasminogen activator system and breast cancer (Review)". Oncology Reports 14, no. 1 (2005): 105-112. https://doi.org/10.3892/or.14.1.105
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