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Print ISSN: 1021-335X Online ISSN: 1791-2431
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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
July 2005 Volume 14 Issue 1

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Journal Metrics

Impact Factor: 4.7

CiteScore: 7.7

CiteScore Rank: Q1: #76/428 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Review

The role of heparanase in gastrointestinal cancer (Review)

Yoshio Naomoto, Munenori Takaoka, Takaomi Okawa, Tetsuji Nobuhisa, Mehmet Gunduz, Noriaki Tanaka
Pages: 3-8
Published online on: 01 July 2005

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Article

Effects of vanadium complexes on cell growth of human leukemia cells and protein-DNA interactions

Ilaria Lampronti, Nicoletta Bianchi, Monica Borgatti, Enrica Fabbri, Leonardo Vizziello, Mahmud Tareq Hassan Khan, Arjumand Ather, Dan Brezena, Mohammad Mahroof Tahir, Roberto Gambari
Pages: 9-15
Published online on: 01 July 2005

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Article

Loss of expression of oestrogen receptor β in colon cancer and its association with Dukes' staging

N. Jassam, S.M. Bell, V. Speirs, P. Quirke
Pages: 17-21
Published online on: 01 July 2005

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Article

Detailed chromosomal characterization of the breast cancer cell line MCF7 with special focus on the expression of the serine-threonine kinase 15

Alexandra Klein, Volker Jung, Klaus D. Zang, Wolfram Henn, Mathias Montenarh, Sabine Kartarius, Wolf-Ingo Steudel, Steffi Urbschat
Pages: 23-31
Published online on: 30 June 2005

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Article

Correlations between antitumor activities of fluoropyrimidines and DPD activity in lung tumor xenografts

Teiji Takechi, Hiroyuki Okabe, Kazumasa Ikeda, Akio Fujioka, Fumio Nakagawa, Hideyuki Ohshimo, Kenji Kitazato, Masakazu Fukushima
Pages: 33-39
Published online on: 01 July 2005

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Article

Differentiation and apoptosis in human malignant melanoma G-361 cells induced by 2-aminophenoxazine-3-one

Shigetaka Shimizu, Mamoru Suzuki, Keisuke Miyazawa, Tomohisa Yokoyama, Kazuma Ohyashiki, Kaori Miyazaki, Akihisa Abe, Akio Tomoda
Pages: 41-46
Published online on: 01 July 2005

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Article

Multiple endocrine neoplasia type 1 gene mutations in sporadic gastrinomas in Japan

Junichiro Kawamura, Yutaka Shimada, Izumi Komoto, Hiroomi Okamoto, Atsushi Itami, Ryuichiro Doi, Koji Fujimoto, Shinji Kosugi, Masayuki Imamura
Pages: 47-52
Published online on: 30 June 2005

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Article

Enhancement of antitumor activity of 5'-deoxy-5-fluorouridine (Furtulon®) by taxane in human gastric cancer xenografts

Noriaki Sawada, Taeko Nose, Tohru Ishikawa, Tanaka Yutaka
Pages: 53-57
Published online on: 01 July 2005

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Article

KAI1 inhibits anchorage-dependent and -independent pancreatic cancer cell growth

Xiao-Zhong Guo, Jian-Hua Xu, Min-pei Liu, Jörg Kleeff, Choon-Kiat Ho, Li-Nan Ren, Hong-Yu Li, Jörg Köninger, Zhong-Min Cui, Di Wang, Chun-Yan Wu, Jia-Jun Zhao, Helmut Friess
Pages: 59-63
Published online on: 01 July 2005

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Article

Analysis of progressively overexpressed genes in tumorigenesis of colorectal cancers using cDNA microarray

Jaw-Yuan Wang, Ching-Sheng Yeh, Wen-Shyong Tzou, Jan-Sing Hsieh, Fang-Ming Chen, Chien-Yu Lu, Fang-Jung Yu, Tian-Lu Cheng, Tsung-Jen Huang, Shiu-Ru Lin
Pages: 65-72
Published online on: 01 July 2005

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Article

5-Lipoxygenase inhibitors attenuate growth of human renal cell carcinoma and induce apoptosis through arachidonic acid pathway

Masahide Matsuyama, Rikio Yoshimura, Makoto Mitsuhashi, Kenji Tsuchida, Yoshiaki Takemoto, Yutaka Kawahito, Hajime Sano, Tatsuya Nakatani
Pages: 73-79
Published online on: 01 July 2005

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Article

Microvascular density, vascular endothelial growth factor immunoreactivity in tumor cells, vessel diameter and intussusceptive microvascular growth in primary melanoma

Domenico Ribatti, Beatrice Nico, Carlo Floris, Domenica Mangieri, Franca Piras, Maria Grazia Ennas, Angelo Vacca, Paola Sirigu
Pages: 81-84
Published online on: 01 July 2005

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Article

Structure-based assessment of BRCA1 and BRCA2 mutations in a small Spanish population

J. Salgado, N. Zabalegui, F. García-Amigot, M. C. Gil, M. S. González, J. García-Foncillas
Pages: 85-88
Published online on: 01 July 2005

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Article

Loss of basement membrane heparan sulfate expression is associated with pelvic lymph node metastasis in invasive cervical cancer

Junichi Kodama, Yasuhiro Shinyo, Hasengaowa, Tomoyuki Kusumoto, Noriko Seki, Keiichiro Nakamura, Atsushi Hongo, Yuji Hiramatsu
Pages: 89-92
Published online on: 01 July 2005

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Article

Expression of insulin-like growth factor-I receptor, estrogen receptor α, Bcl-2 and Bax proteins in human breast cancer

Mariusz Koda, Wojciech Przystupa, Katarzyna Jarzabek, Andrzej Wincewicz, Luiza Kanczuga-Koda, Jakub Tomaszewski, Mariola Sulkowska, Slawomir Wolczynski, Stanislaw Sulkowski
Pages: 93-98
Published online on: 01 July 2005

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Article

Non-anti-coagulant heparin inhibits metastasis but not primary tumor growth

Michael Kragh, Lise Binderup, Pernille-Julia Vig Hjarnaa, Erik Bramm, Kristian B. Johansen, Christian Frimundt Petersen
Pages: 99-104
Published online on: 01 July 2005

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Review

Urokinase-type plasminogen activator system and breast cancer (Review)

Bo Han, Misa Nakamura, Ichiro Mori, Yasushi Nakamura, Kennichi Kakudo
Pages: 105-112
Published online on: 01 July 2005

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Article

Flow cytometric analysis of circulating dendritic cell subsets and intracellular cytokine production in advanced breast cancer patients

Silvia Ferrari, Fabio Malugani, Bianca Rovati, Camillo Porta, Alberto Riccardi, Marco Danova
Pages: 113-120
Published online on: 01 July 2005

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Article

Cellular kinetics and K-ras codon 12 mutations according to histomorphometric type of colorectal polyps with epithelial serrated proliferation

Shigeharu Hamatani, Ryo Wada, Ayako Morita, Chikako Hasegawa, Aki Mitsuda, Tsutomu Hatori, Hiroko Nonaka, Keiji Takahashi, Shina Gomi, Kazutoshi Shibuya
Pages: 121-127
Published online on: 01 July 2005

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Article

A multicenter randomized study comparing 5-fluorouracil continuous infusion (ci) plus 1-hexylcarbamoyl-5-fluorouracil and 5-FU ci alone in colorectal cancer

Kenjiro Kotake, Yasuo Ohashi, Susumu Kodaira, Yasuo Koyama, East-Japan Colorectal Cancer Chemotherapy Study Group
Pages: 129-134
Published online on: 01 July 2005

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Article

Chemotherapy under cachectic conditions and the possibility of cachexia-controlled chemotherapy

Yutaka Takahashi, Kazuo Yasumoto, Masayoshi Mai
Pages: 135-140
Published online on: 01 July 2005

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Article

K252a inhibits proliferation of ovarian cancer cells by upregulating p21WAF1

Noriyuki Takai, Tami Ueda, Masakazu Nishida, Kaei Nasu, Junichiro Fukuda, Isao Miyakawa
Pages: 141-143
Published online on: 01 July 2005

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Article

Induction of S phase cell arrest and caspase activation by polysaccharide peptide isolated from Coriolus versicolor enhanced the cell cycle dependent activity and apoptotic cell death of doxorubicin and etoposide, but not cytarabine in HL-60 cells

Kenrie Pui-Yan Hui, Wai-Hung Sit, Jennifer Man-Fan Wan
Pages: 145-155
Published online on: 01 July 2005

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Article

Inhibitory effect of glycolipids from spinach on in vitro and ex vivo angiogenesis

Kiminori Matsubara, Hiroaki Matsumoto, Yoshiyuki Mizushina, Masaharu Mori, Nobuyoshi Nakajima, Michiko Fuchigami, Hiromi Yoshida, Takahiko Hada
Pages: 157-160
Published online on: 01 July 2005

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Article

Expression of nerve growth factor receptors and their prognostic value in human pancreatic cancer

Yong Zhang, Chengxue Dang, Qingyong Ma, Yasuyuki Shimahara
Pages: 161-171
Published online on: 01 July 2005

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Article

Occult neoplastic cells and malignant micro-aggregates in lymph node sinuses: Review and hypothesis

Masaya Mukai
Pages: 173-175
Published online on: 01 July 2005

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Article

Combination of 5-deoxy-5-fluorouridine and tamoxifen show cell-type specific antagonistic and cooperative effects on cytotoxicity in human mammary carcinoma cells

Aliccia Bollig, Qian-qian Du, Shing-tzu Fan, Ben Yu, Fazlul H. Sarkar, Joshua Liao
Pages: 177-183
Published online on: 01 July 2005

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Article

Polymorphism of the MUC1 mucin gene is associated with susceptibility to lung adenocarcinoma and poor prognosis

Kazuhiro Mitsuta, Akihito Yokoyama, Keiichi Kondo, Masamitsu Nakajima, Ken-ichi Arita, Nobuoki Kohno
Pages: 185-189
Published online on: 01 July 2005

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Article

Methylation of the MLH1 gene in hematological malignancies

Masahide Matsushita, Seisho Takeuchi, Yang Yang, Norihide Yoshino, Kunihiro Tsukasaki, Hirokuni Taguchi, H. Phillip Koeffler, Hiromi Seo
Pages: 191-194
Published online on: 01 July 2005

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Article

The extending range of the tumor is a more suitable predictive risk factor for lymph node metastases than the location of the deepest tumor invasion in distal thoracic esophageal and cardiac cancer

Atsushi Shiozaki, Hirosumi Itoi, Yuji Ueda, Teruhisa Sonoyama, Hisakazu Yamagishi
Pages: 195-199
Published online on: 01 July 2005

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Article

Evaluation of 5-fluorouracil applicability by multi-point collagen gel droplet embedded drug sensitivity test

Takumi Ochiai, Kazuhiko Nishimura, Hajime Noguchi, Masayuki Kitajima, Yuko Tsuruoka, Yuka Takahashi
Pages: 201-205
Published online on: 01 July 2005

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Article

Efficacy of platinum-based chemotherapy after cranial radiation in patients with brain metastasis from non-small cell lung cancer

Dae-Young Kim, Keun-Wook Lee, Tak Yun, Dong-Wan Kim, Tae-You Kim, Dae Seog Heo, Yung-Jue Bang, Noe Kyeong Kim
Pages: 207-211
Published online on: 01 July 2005

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Article

Combination of copper-chelating agent, trientine, and methotrexate attenuates colorectal carcinoma development and angiogenesis in mice

Hitoshi Yoshiji, Junichi Yoshii, Shigeki Kuriyama, Yasuhide Ikenaka, Ryuichi Noguchi, Koji Yanase, Tadashi Namisaki, Mitsuteru Kitade, Masaharu Yamazaki, Hiroshi Fukui
Pages: 213-218
Published online on: 30 June 2005

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Article

Simple mucin-type cancer associated antigens are pre-cancerous biomarkers during 1,2-dimethylhydrazine-induced rat colon carcinogenesis

Edgardo Berriel, Marcelo Hill, Juan J. Barcia, Luis Ubillos, Mariela Gonzalez, Gisselle Detjen, Mariella Rondan, Héctor Navarrete, Eduardo Osinaga
Pages: 219-227
Published online on: 01 July 2005

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Article

Differentially expressed genes associated with human lung cancer

Wei Xiao, Manuela Pacyna-Gengelbach, Karsten Schlüns, Qian An, Yanning Gao, Shujun Cheng, Iver Petersen
Pages: 229-234
Published online on: 30 June 2005

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Article

Measurement of plasminogen activator system components in plasma and tumor tissue extracts obtained from patients with breast cancer: An EORTC Receptor and Biomarker Group collaboration

N. Grebenchtchikov, T. M. Maguire, R. Riisbro, A. Geurts-Moespot, N. O'Donovan, M. Schmitt, G. McGreal, E. McDermott, N. O'Higgins, N. Brünner, C. G.J. Sweep, M. J. Duffy
Pages: 235-239
Published online on: 01 July 2005

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Article

Prognostic and predictive relevance of microsatellite instability in colorectal cancer

Iana Storojeva, Jean-Louis Boulay, Karl Heinimann, Pierluigi Ballabeni, Luigi Terracciano, Urban Laffer, Gabriele Mild, Richard Herrmann, Christoph Rochlitz
Pages: 241-249
Published online on: 30 June 2005

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Article

Qualitative and quantitative analysis of angiogenetic factors in transitional cell bladder carcinoma: Relationship with clinical course at 10 years follow-up

Riccardo Bartoletti, Tommaso Cai, Gabriella Nesi, Iacopo Sardi, Michelangelo Rizzo
Pages: 251-255
Published online on: 01 July 2005

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Article

Systemic inflammation correlates with increased expression of skeletal muscle ubiquitin but not uncoupling proteins in cancer cachexia

Cornelis H.C. Dejong, Sylvia Busquets, Alastair G.W. Moses, Patrick Schrauwen, Jim A. Ross, Josep M. Argiles, Kenneth C.H. Fearon
Pages: 257-263
Published online on: 01 July 2005

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Article

A high-fat diet enhances the inhibitory effect of dietary vitamin B6 on colon cell proliferation in mice

Shun-Ichiro Komatsu, Masami Isobe, Noriyuki Yanaka, Norihisa Kato
Pages: 265-269
Published online on: 01 July 2005

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Article

Human DNA topoisomerase II-α expression in laparoscopically treated renal cell carcinoma

Yoram Dekel, Thomas Frede, Valentina Kugel, Gad Neumann, Jens Rassweiler, Rumelia Koren
Pages: 271-274
Published online on: 01 July 2005

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Article

Induction of apoptosis in human ovarian epithelial cancer cells by antisurvivin oligonucleotides

Xiangyi Ma, Shixuan Wang, Jianfeng Zhou, Hui Xing, Gang Xu, Beibei Wang, Gang Chen, Yun-Ping Lu, Ding Ma
Pages: 275-279
Published online on: 01 July 2005

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Article

Cisplatin sensitization by concurrent mild hyperthermia in parental and mutant cell lines deficient in homologous recombination and non-homologous endjoining repair

G. P. Raaphorst, L. F. Li, D. P. Yang, J.-M. Leblanc
Pages: 281-285
Published online on: 01 July 2005

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Article

Comparative genomics on FGF20 orthologs

Masuko Katoh, Masaru Katoh, Yuriko Katoh
Pages: 287-290
Published online on: 30 June 2005

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Article

Comparative genomics on Fgf11 orthologs.

Yuriko Katoh, Masaru Katoh
Pages: 291-295
Published online on: 01 July 2005

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Journal Cover
November-2026 Volume 56 Issue 5

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Journal Metrics

Impact Factor: 4.7

CiteScore: 7.7

CiteScore Rank: Q1: #76/428 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Article Open Access

Targeting the DNHD1‑HDAC6 axis inactivates prostate cancer cell aggressiveness in vitro, suggesting potential therapeutic vulnerability

An Ni Lee, Chia Chang Wu, Su Wei Hu, Chih Heng Chen, Yi Te Chiang, Wei Tang Kao, Kai Yi Tzou, Chia Hung Liu, Shao Wei Dong, Yu Ting Wang, Yueh Lin Lee, Siou Bi Li, Che An Wu, Chiao Chun Liao, Ming Hsien Chan, Po Han Chiu, Chien Hsiu Li
Article Number: 198
Published online on: 30 September 2026

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Article Open Access

Loperamide enhances the radiosensitivity of cervical cancer cells via ferroptosis induction

Huarong Guo, Haixia Li, Shunkang Tian, Yunkai Zhang, Fuyun Wu, Jing Ke
Article Number: 197
Published online on: 30 September 2026

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Review Open Access

Mitochondrial mechanisms underlying spatial immune phenotypes in non‑small cell lung cancer: Implications for ICI response and cold‑to‑hot tumor conversion (Review)

Hongyi Lai, Ke Sun, Tong Mu, Xi Liu, Mingshan Liu
Article Number: 196
Published online on: 30 September 2026

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Article Open Access

PINK1 promotes the progression of lung squamous cell carcinoma through the FAK/AKT/RhoA/vinculin pathway

Xu Li, Yuhui Ma
Article Number: 195
Published online on: 29 September 2026

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Expression of Concern Open Access

[Expression of Concern] MicroRNA‑195‑5p is a potential diagnostic and therapeutic target for breast cancer

Qifeng Luo, Chuankui Wei, Xiaoyu Li, Jia Li, Lei Chen, Yixiang Huang, Hongming Song, Dengfeng Li, Lin Fang
Article Number: 194
Published online on: 23 September 2026

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Article Open Access

SGPP1 as a tumor suppressor in esophageal squamous cell carcinoma: Potential molecular mechanisms involving UGT1A9/UGT2B28 and clinical prognostic significance

Linlin Su, Liubing Hou, Xuetao Han, Ge Zhang, Jiayuan Li, Yu Wang, Yuxin Han, Xiaoying Xue, Huandi Zhou
Article Number: 193
Published online on: 23 September 2026

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Correction Open Access

[Corrigendum] High expression of hnRNPA1 promotes cell invasion by inducing EMT in gastric cancer

Yahua Chen, Jun Liu, Wei Wang, Li Xiang, Jide Wang, Side Liu, Hongyan Zhou, Zheng Guo
Article Number: 192
Published online on: 21 September 2026

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Review Open Access

Overcoming melanoma drug resistance: Mechanisms and clinical progress of oncolytic viruses combined with immune checkpoint inhibitors (Review)

Yuan He, Wenxuan Lin, Haofang Chen, Yongqi Guan, Congcong Guan, Yanxiang Zhang, Dongsheng Pan
Article Number: 191
Published online on: 17 September 2026

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Article Open Access

Validation of next‑generation sequencing‑derived circulating mRNA variants as potential diagnostic tools in hepatocellular carcinoma and cholangiocarcinoma

Daniel Zezulinski, Maarouf A. Hoteit, David E. Kaplan, Tingting Zhan, Cataldo Doria, Timothy M. Block, Aejaz Sayeed
Article Number: 190
Published online on: 16 September 2026

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Correction Open Access

[Corrigendum] The interaction between miR‑148a and DNMT1 suppresses cell migration and invasion by reactivating tumor suppressor genes in pancreatic cancer

Le Hong, Gen Sun, Long Peng, Yi Tu, Zhen Wan, Haiwei Xiong, Yong Li, Weidong Xiao
Article Number: 189
Published online on: 16 September 2026

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Article Open Access

Pemetrexed increases BRCA1 protein stability and sensitizes TNBC cells to radiotherapy

Hee Jin, Kyung-Hwa Jeon, Chaerin Kang, Joohyun Lee, Yeonjin Lee, Youngjoo Kwon, Yun-Sil Lee
Article Number: 188
Published online on: 15 September 2026

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Article Open Access

FXYD5 promotes the growth of glioblastoma by targeting the PI3K/AKT/ACSL4 signaling axis

Bang Wang, Yong Qin, Hang Cheng, Yibin Zeng, Lianglei Jiang, Xuebin Hu
Article Number: 187
Published online on: 14 September 2026

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Expression of Concern Open Access

[Expression of Concern] RIP kinase‑mediated ROS production triggers XAF1 expression through activation of TAp73 in casticin‑treated bladder cancer cells

Yoon Hee Chung, Daejin Kim
Article Number: 186
Published online on: 14 September 2026

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Expression of Concern Open Access

[Expression of Concern] In vitro and in vivo activities of an antitumor peptide HM‑3: A special dose‑efficacy relationship on an HCT‑116 xenograft model in nude mice

Sitelbanat Yassin, Jialiang Hu, Hanmei Xu, Ce Li, Sarra Setrerrahmane
Article Number: 185
Published online on: 10 September 2026

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Article Open Access

Effect of EZH2 regulation of the JAK2/STAT3 signaling pathway on proliferation and apoptosis in non‑small cell lung cancer cells

Shuang Wu, Wei Zhang
Article Number: 184
Published online on: 08 September 2026

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Correction Open Access

[Corrigendum] TGF‑β1 mediates epithelial to mesenchymal transition via the TGF‑β/Smad pathway in squamous cell carcinoma of the head and neck

Changyun Yu, Yong Liu, Donghai Huang, Yaozhang Dai, Gengming Cai, Jinjie Sun, Ting Xu, Yongquan Tian, Xin Zhang
Article Number: 183
Published online on: 31 August 2026

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December-2026 Volume 56 Issue 6

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Journal Metrics

Impact Factor: 4.7

CiteScore: 7.7

CiteScore Rank: Q1: #76/428 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Expression of Concern Open Access

[Expression of Concern] ZNF703 promotes tumor cell proliferation and invasion and predicts poor prognosis in patients with colorectal cancer

Feng Ma, Lihong Bi, Gongli Yang, Mengnan Zhang, Cuiping Liu, Yingying Zhao, Yadong Wang, Jide Wang, Yang Bai, Yali Zhang
Article Number: 199
Published online on: 30 September 2026

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