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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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July 2005 Volume 14 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Chemotherapy under cachectic conditions and the possibility of cachexia-controlled chemotherapy

  • Authors:
    • Yutaka Takahashi
    • Kazuo Yasumoto
    • Masayoshi Mai

  • View Affiliations / Copyright

    Affiliations: Department of Surgical Oncology, Cancer Research Institute, Kanazawa University, 13-1 Takaramachi, Kanazawa 920-8641, Japan. takahasi@kenroku.kanazawa-u.ac.jp
  • Pages: 135-140
    |
    Published online on: July 1, 2005
       https://doi.org/10.3892/or.14.1.135
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Abstract

We studied the role of chemotherapy in cancer cachexia, which is well known to lower QOL and responsiveness to chemotherapy. In BALB/c mice we used two clones derived from the murine colon 26 adenocarcinoma cell line; clone 5, a non-cachexigenic tumor and clone 20, a cachexigenic tumor, in which IL-6 mRNA was selectively detected. While maximum tolerated dose (MTD) of CPM and CPT-11 showed significantly smaller tumor weight and higher survival than 1/2 MTD in both drug groups with clone 5, the results were reversed with clone 20. The tumor weights with MTD of CPM or CPT-11 in combination with anti-IL-6 antibody treatment, which decreases serum IL-6 level and improves cachexia status, were significantly smaller than those in the MTD treatment-alone group with clone 20, but not with clone 5. From these results, we suggest that lower dose chemotherapy or cachexia-controlled chemotherapy, such as some chemotherapeutic agents with neutralizing cachexia-related cytokine effects, elicit anti-tumor effects in cachectic individuals that are superior to conventional MTD chemotherapy.

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Copy and paste a formatted citation
Spandidos Publications style
Takahashi Y, Yasumoto K and Mai M: Chemotherapy under cachectic conditions and the possibility of cachexia-controlled chemotherapy. Oncol Rep 14: 135-140, 2005.
APA
Takahashi, Y., Yasumoto, K., & Mai, M. (2005). Chemotherapy under cachectic conditions and the possibility of cachexia-controlled chemotherapy. Oncology Reports, 14, 135-140. https://doi.org/10.3892/or.14.1.135
MLA
Takahashi, Y., Yasumoto, K., Mai, M."Chemotherapy under cachectic conditions and the possibility of cachexia-controlled chemotherapy". Oncology Reports 14.1 (2005): 135-140.
Chicago
Takahashi, Y., Yasumoto, K., Mai, M."Chemotherapy under cachectic conditions and the possibility of cachexia-controlled chemotherapy". Oncology Reports 14, no. 1 (2005): 135-140. https://doi.org/10.3892/or.14.1.135
Copy and paste a formatted citation
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Spandidos Publications style
Takahashi Y, Yasumoto K and Mai M: Chemotherapy under cachectic conditions and the possibility of cachexia-controlled chemotherapy. Oncol Rep 14: 135-140, 2005.
APA
Takahashi, Y., Yasumoto, K., & Mai, M. (2005). Chemotherapy under cachectic conditions and the possibility of cachexia-controlled chemotherapy. Oncology Reports, 14, 135-140. https://doi.org/10.3892/or.14.1.135
MLA
Takahashi, Y., Yasumoto, K., Mai, M."Chemotherapy under cachectic conditions and the possibility of cachexia-controlled chemotherapy". Oncology Reports 14.1 (2005): 135-140.
Chicago
Takahashi, Y., Yasumoto, K., Mai, M."Chemotherapy under cachectic conditions and the possibility of cachexia-controlled chemotherapy". Oncology Reports 14, no. 1 (2005): 135-140. https://doi.org/10.3892/or.14.1.135
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