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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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July 2005 Volume 14 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Medicine International

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Article

Differentiation and apoptosis in human malignant melanoma G-361 cells induced by 2-aminophenoxazine-3-one

  • Authors:
    • Shigetaka Shimizu
    • Mamoru Suzuki
    • Keisuke Miyazawa
    • Tomohisa Yokoyama
    • Kazuma Ohyashiki
    • Kaori Miyazaki
    • Akihisa Abe
    • Akio Tomoda

  • View Affiliations / Copyright

    Affiliations: Department of Otorhinolaryngology, Tokyo Medical University, 5-7-1 Nishishinjuku, Tokyo 160-0023, Japan
  • Pages: 41-46
    |
    Published online on: July 1, 2005
       https://doi.org/10.3892/or.14.1.41
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Abstract

Inhibitory effects of 2-amino-4,4α-dihydro-4α,7-dimethyl-3H-phenoxazine-3-one (Phx-1), 2-amino-4,4α-dihydro-4α,7-dimethyl-3H-phenoxazine-3-one (Phx-2) and 2-aminophenoxazine-3-one (Phx-3), which were produced by the reaction of o-aminophenol and its derivatives with bovine hemoglobin, on the proliferation of human malignant melanoma G-361 cells were studied under various conditions. Phx-1 and Phx-3 showed anti-proliferative effects on human malignant melanoma G-361 cells, however Phx-2 did not. Phx-3, which exerted the strongest anti-proliferative effects, inhibited the proliferation of human malignant melanoma G-361 cells during 24 h incubation at concentrations of ≥10 µM. Apoptosis and G1 arrest in the cells, which were detected by DNA laddering on electrophoresis and flow cytometry, respectively, were observed when the melanoma G-361 cells were treated with Phx-3 at 37°C for 24 h. Concomitantly, the increased melanin formation in G-361 cells was indicated by biochemical and morphological detection of melanin within 24 h exposure to Phx-3. The present results suggest that Phx-3 exclusively demonstrates anti-tumor activity against human malignant melanoma G-361 cells by inducing cell cycle accumulation at G1, differentiation and apoptosis.

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Copy and paste a formatted citation
Spandidos Publications style
Shimizu S, Suzuki M, Miyazawa K, Yokoyama T, Ohyashiki K, Miyazaki K, Abe A and Tomoda A: Differentiation and apoptosis in human malignant melanoma G-361 cells induced by 2-aminophenoxazine-3-one. Oncol Rep 14: 41-46, 2005.
APA
Shimizu, S., Suzuki, M., Miyazawa, K., Yokoyama, T., Ohyashiki, K., Miyazaki, K. ... Tomoda, A. (2005). Differentiation and apoptosis in human malignant melanoma G-361 cells induced by 2-aminophenoxazine-3-one. Oncology Reports, 14, 41-46. https://doi.org/10.3892/or.14.1.41
MLA
Shimizu, S., Suzuki, M., Miyazawa, K., Yokoyama, T., Ohyashiki, K., Miyazaki, K., Abe, A., Tomoda, A."Differentiation and apoptosis in human malignant melanoma G-361 cells induced by 2-aminophenoxazine-3-one". Oncology Reports 14.1 (2005): 41-46.
Chicago
Shimizu, S., Suzuki, M., Miyazawa, K., Yokoyama, T., Ohyashiki, K., Miyazaki, K., Abe, A., Tomoda, A."Differentiation and apoptosis in human malignant melanoma G-361 cells induced by 2-aminophenoxazine-3-one". Oncology Reports 14, no. 1 (2005): 41-46. https://doi.org/10.3892/or.14.1.41
Copy and paste a formatted citation
x
Spandidos Publications style
Shimizu S, Suzuki M, Miyazawa K, Yokoyama T, Ohyashiki K, Miyazaki K, Abe A and Tomoda A: Differentiation and apoptosis in human malignant melanoma G-361 cells induced by 2-aminophenoxazine-3-one. Oncol Rep 14: 41-46, 2005.
APA
Shimizu, S., Suzuki, M., Miyazawa, K., Yokoyama, T., Ohyashiki, K., Miyazaki, K. ... Tomoda, A. (2005). Differentiation and apoptosis in human malignant melanoma G-361 cells induced by 2-aminophenoxazine-3-one. Oncology Reports, 14, 41-46. https://doi.org/10.3892/or.14.1.41
MLA
Shimizu, S., Suzuki, M., Miyazawa, K., Yokoyama, T., Ohyashiki, K., Miyazaki, K., Abe, A., Tomoda, A."Differentiation and apoptosis in human malignant melanoma G-361 cells induced by 2-aminophenoxazine-3-one". Oncology Reports 14.1 (2005): 41-46.
Chicago
Shimizu, S., Suzuki, M., Miyazawa, K., Yokoyama, T., Ohyashiki, K., Miyazaki, K., Abe, A., Tomoda, A."Differentiation and apoptosis in human malignant melanoma G-361 cells induced by 2-aminophenoxazine-3-one". Oncology Reports 14, no. 1 (2005): 41-46. https://doi.org/10.3892/or.14.1.41
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