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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
Journal Cover
August 2005 Volume 14 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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August 2005 Volume 14 Issue 2

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Article

Analysis of gene expression during staurosporine-induced neuronal differentiation of human prostate cancer cells

  • Authors:
    • Takahisa Shimizu
    • Akiko Okayama
    • Toshihiro Inoue
    • Ken Takeda

  • View Affiliations / Copyright

    Affiliations: Department of Hygiene-chemistry, Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki Noda-shi, Chiba 278-8510, Japan. takahisa@rs.noda.tus.ac.jp
  • Pages: 441-448
    |
    Published online on: August 1, 2005
       https://doi.org/10.3892/or.14.2.441
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Abstract

Staurosporine induces neuronal differentiation and suppresses malignancy of human prostate cancer TSU-Pr1 cells. To investigate the mechanism underlying neuronal differentiation and suppression of malignancy, we used cDNA microarrays to examine gene expression profiles in TSU-Pr1 cells treated with staurosporine. mRNAs isolated from untreated and staurosporine-treated TSU-Pr1 cells were hybridised to microarrays consisting of ~9100 genes. Changes in gene expression were verified by Northern blot analysis. Staurosporine-responsive genes were involved in a variety of cellular functions including growth regulation, differentiation, replication, DNA repair, G2/M transition and inhibition of apoptosis. Interestingly, expression of genes associated with cell proliferation and malignancy, such as Cyr61 and CTGF, was reduced. Expression of CD73/NT5E, which is involved in neuronal differentiation, was increased. In the present study, we identified various staurosporine-responsive genes in TSU-Pr1 cells. Further studies of the roles of these genes may clarify the mechanisms underlying neuronal differentiation and inhibition of malignancy by staurosporine and identify better approaches for the prevention and treatment of prostate cancer.

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Copy and paste a formatted citation
Spandidos Publications style
Shimizu T, Okayama A, Inoue T and Takeda K: Analysis of gene expression during staurosporine-induced neuronal differentiation of human prostate cancer cells. Oncol Rep 14: 441-448, 2005.
APA
Shimizu, T., Okayama, A., Inoue, T., & Takeda, K. (2005). Analysis of gene expression during staurosporine-induced neuronal differentiation of human prostate cancer cells. Oncology Reports, 14, 441-448. https://doi.org/10.3892/or.14.2.441
MLA
Shimizu, T., Okayama, A., Inoue, T., Takeda, K."Analysis of gene expression during staurosporine-induced neuronal differentiation of human prostate cancer cells". Oncology Reports 14.2 (2005): 441-448.
Chicago
Shimizu, T., Okayama, A., Inoue, T., Takeda, K."Analysis of gene expression during staurosporine-induced neuronal differentiation of human prostate cancer cells". Oncology Reports 14, no. 2 (2005): 441-448. https://doi.org/10.3892/or.14.2.441
Copy and paste a formatted citation
x
Spandidos Publications style
Shimizu T, Okayama A, Inoue T and Takeda K: Analysis of gene expression during staurosporine-induced neuronal differentiation of human prostate cancer cells. Oncol Rep 14: 441-448, 2005.
APA
Shimizu, T., Okayama, A., Inoue, T., & Takeda, K. (2005). Analysis of gene expression during staurosporine-induced neuronal differentiation of human prostate cancer cells. Oncology Reports, 14, 441-448. https://doi.org/10.3892/or.14.2.441
MLA
Shimizu, T., Okayama, A., Inoue, T., Takeda, K."Analysis of gene expression during staurosporine-induced neuronal differentiation of human prostate cancer cells". Oncology Reports 14.2 (2005): 441-448.
Chicago
Shimizu, T., Okayama, A., Inoue, T., Takeda, K."Analysis of gene expression during staurosporine-induced neuronal differentiation of human prostate cancer cells". Oncology Reports 14, no. 2 (2005): 441-448. https://doi.org/10.3892/or.14.2.441
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