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Print ISSN: 1021-335X Online ISSN: 1791-2431
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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
August 2005 Volume 14 Issue 2

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Journal Metrics

Impact Factor: 3.9

CiteScore: 8.3

CiteScore Rank: Q1: #73/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Article

Do cancer cells selectively mutate HFE to increase their intracellular iron?

Claudia I. Müller, Carl W. Miller, Hiroshi Kawabata, Robert J. McKenna, Alberto M. Marchevsky, H. Phillip Koeffler
Pages: 299-303
Published online on: 01 August 2005

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Article

EGFR activity in HER-2 over-expressing metastatic breast cancer: evidence for simultaneous phosphorylation of Her-2/neu and EGFR

Daphne Gschwantler-Kaulich, Gernot Hudelist, Wolfgang J. Koestler, Klaus Czerwenka, Ruth Mueller, Samir Helmy, Ernst Ruecklinger, Ernst Kubista, Christian F. Singer
Pages: 305-311
Published online on: 01 August 2005

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Article

ATM expression in rectal cancers with or without preoperative radiotherapy

Linda Ärlehag, Gunnar Adell, Annica Knutsen, Sten Thorstenson, Xiao-Feng Sun
Pages: 313-317
Published online on: 01 August 2005

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Article

Molecular clonal analysis of recurrent bladder cancer

Kerstin Junker, Michael Wolf, Jörg Schubert
Pages: 319-323
Published online on: 01 August 2005

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Article

Connexins 26 and 43 correlate with Bak, but not with Bcl-2 protein in breast cancer

Luiza Kanczuga-Koda, Stanislaw Sulkowski, Jakub Tomaszewski, Mariusz Koda, Mariola Sulkowska, Wojciech Przystupa, Jolanta Golaszewska, Marek Baltaziak
Pages: 325-329
Published online on: 01 August 2005

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Article

The activities of thymidine phosphorylase and dihydropyrimidine dehydrogenase in colorectal cancer depend on where the sample is taken

Masaichi Ogawa, Kenji Ikeuchi, Yoshihiko Takao, Tetsuya Kobayashi, Ken Eto, Takurou Ushigome, Michiaki Watanabe, Sadao Anazawa, Yoji Yamazaki, Katsuhiko Yanaga
Pages: 331-335
Published online on: 01 August 2005

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Article

Estrogen receptor-negative and human epidermal growth factor receptor 2-negative breast cancer tissue have the highest Ki-67 labeling index and EGFR expression: Gene amplification does not contribute to EGFR expression

Shinobu Umemura, Susumu Takekoshi, Yasuhiro Suzuki, Yuki Saitoh, Yutaka Tokuda, R. Yoshiyuki Osamura
Pages: 337-343
Published online on: 01 August 2005

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Article

Suppression of β-catenin mutation by dietary exposure of auraptene, a citrus antioxidant, in N,N-diethylnitrosamine-induced hepatocellular carcinomas in rats

Akira Hara, Keiko Sakata, Yasuhiro Yamada, Toshiya Kuno, Nami Kitaori, Takeru Oyama, Yoshinobu Hirose, Akira Murakami, Takuji Tanaka, Hideki Mori
Pages: 345-351
Published online on: 01 August 2005

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Article

Prognostic significance of CD83 positive, mature dendritic cells in the gallbladder carcinoma

Makoto Furihata, Yuko Ono, Kazuhito Ichikawa, Shigeki Tomita, Takahiro Fujimori, Keiichi Kubota
Pages: 353-356
Published online on: 01 August 2005

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Article

Clinical significance of the expression of tumor-associated antigen, RCAS1, and its soluble protein in pleural fluid in malignant mesothelioma

Akio Hiraki, Keisuke Aoe, Tomoyuki Murakami, Yuichi Nakamura, Koich Yamazaki, Naoko Sueoka, Koji Taguchi, Toshiaki Kamei, Tadashi Maeda, Hiroyasu Takeyama, Takumi Kishimoto, Masaharu Nishimura, Kazuro Sugi
Pages: 357-362
Published online on: 01 August 2005

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Article

Clinical significance of p21WAF1/CIP1 and p53 expression in serous cystadenocarcinoma of the ovary

Fumitoshi Terauchi, Aikou Okamoto, Takeo Nagashima, Yukari Kobayashi, Tetsuya Moritake, Yasuhiro Yamamoto, Satoshi Takakura, Satoko Iwaki, Hisao Ogura
Pages: 363-368
Published online on: 01 August 2005

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Article

Prognostic value of CD83-positive mature dendritic cells and their relation to vascular endothelial growth factor in advanced human gastric cancer

Shoichi Tsukayama, Kenji Omura, Koichi Yoshida, Yoko Tanaka, Go Watanabe
Pages: 369-375
Published online on: 01 August 2005

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Article

Suppression of chemically-induced liver tumors by castration or estradiol-3-benzoate treatment in F344 rats

Jin Seok Kang, Byeongwoo Ahn, Chuel Kyu Kim, Beom Seok Han, Jeong-Hwan Che, Seyl Kim, Dong Deuk Jang, Ki-Hwa Yang
Pages: 377-382
Published online on: 01 August 2005

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Article

Growth effect of gastrin on gastric cancer and its clinical implications for gastric cancer surgery

Hyeon Kook Lee, Hyuk-Joon Lee, Keun Hur, Hye Seung Lee, Woo Ho Kim, Dov Michaeli, Kuk Jin Choe, Han-Kwang Yang
Pages: 383-388
Published online on: 01 August 2005

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Article

PTEN-positive and phosphorylated-Akt-negative expression is a predictor of survival for patients with advanced endometrial carcinoma

Kazunori Uegaki, Yasunobu Kanamori, Junzo Kigawa, Wakae Kawaguchi, Ruri Kaneko, Jun Naniwa, Masakuni Takahashi, Muneaki Shimada, Tetsuro Oishi, Hiroaki Itamochi, Naoki Terakawa
Pages: 389-392
Published online on: 01 August 2005

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Article

Combination of the antivascular agent ZD6126 with hypoxic cytotoxin treatment, with reference to the effect on quiescent tumor cells and the dependency on p53 status of tumor cells

Shin-ichiro Masunaga, Hideko Nagasawa, Yoshihiro Uto, Hitoshi Hori, Ken Ohnishi, Akihisa Takahashi, Takeo Ohnishi, Minoru Suzuki, Kenji Nagata, Yuko Kinashi, Koji Ono
Pages: 393-400
Published online on: 01 August 2005

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Article

Phase II study on low dose gemcitabine plus oral chemotherapy with uracil-tegafur and cyclophosphamide in combination with radiotherapy against recurrent and advanced pancreatic cancer

Yoshinori Nio, Koji Hashimoto, Seiji Yano, Masayuki Itakura, Makoto Koike, Kazushige Yamaguchi, Shinichiro Endo, Munechika Tsuji, Tetsuya Higami, Riruke Maruyama
Pages: 401-408
Published online on: 01 August 2005

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Article

Suppression of glutathione S-transferase placental form-positive foci development in rat hepatocarcinogenesis by Chlorella pyrenoidosa

Hideo Takekoshi, Toru Mizoguchi, Yoko Komasa, Hirofumi Chubachi, Yukari Inoue, Hideyo Imanishi, Masuo Nakano
Pages: 409-414
Published online on: 01 August 2005

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Article

FGFR4 Gly388Arg polymorphism and prognosis of breast and colorectal cancer

Monica Spinola, Vera Piera Leoni, Jun-ichi Tanuma, Angela Pettinicchio, Milo Frattini, Stefano Signoroni, Roberto Agresti, Riccardo Giovanazzi, Silvana Pilotti, Lucio Bertario, Fernando Ravagnani, Tommaso A. Dragani
Pages: 415-419
Published online on: 01 August 2005

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Article

The modifier subunit of glutamate cysteine ligase relates to cisplatin resistance in human small cell lung cancer xenografts in vivo

Masatake Nishi, Yoshiyuki Abe, Sakashi Fujimori, Atsushi Hamamoto, Yoshimasa Inoue, Noriyuki Miyazaki, Yasuhisa Oida, Norihiro Ikoma, Yasuyuki Ohnishi, Hitoshi Yamazaki, Yoshito Ueyama, Masato Nakamura
Pages: 421-424
Published online on: 01 August 2005

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Article

Macrophage infiltration and its prognostic implications in breast cancer: The relationship with VEGF expression and microvessel density

Shinichi Tsutsui, Kazuhiro Yasuda, Kosuke Suzuki, Kouichirou Tahara, Hidefumi Higashi, Shoichi Era
Pages: 425-431
Published online on: 01 August 2005

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Article

Toxicity during l-LV/5FU adjuvant chemotherapy as a modified RPMI regimen for patients with colorectal cancer

Tsukasa Hotta, Katsunari Takifuji, Kazuo Arii, Shozo Yokoyama, Kenji Matsuda, Takashi Higashiguchi, Toshiji Tominaga, Yoshimasa Oku, Hiroki Yamaue
Pages: 433-439
Published online on: 01 August 2005

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Article

Analysis of gene expression during staurosporine-induced neuronal differentiation of human prostate cancer cells

Takahisa Shimizu, Akiko Okayama, Toshihiro Inoue, Ken Takeda
Pages: 441-448
Published online on: 01 August 2005

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Article

Reduced syndecan-1 expression stimulates heparin-binding growth factor-mediated invasion in ovarian cancer cells in a urokinase-independent mechanism

Hidenori Matsuzaki, Hiroshi Kobayashi, Tatsuo Yagyu, Kiyoshi Wakahara, Toshiharu Kondo, Noriyuki Kurita, Hideo Sekino, Kiyokazu Inagaki, Mika Suzuki, Naohiro Kanayama, Toshihiko Terao
Pages: 449-457
Published online on: 01 August 2005

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Article

Sequence variation and the transcriptional activity of the upstream regulatory region in human papillomavirus 16 E7 variants in cervical cancer of Korean women

Yong Beom Kim, Yong Sang Song, Yong Tark Jeon, Jong Sup Park, Soo Jong Um, Jae Weon Kim, Noh Hyun Park, Soon Beom Kang, Hyo Pyo Lee
Pages: 459-464
Published online on: 01 August 2005

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Article

A single nucleotide polymorphism in the extracellular domain of TRAIL receptor DR4 at nucleotide 626 in gastric cancer patients in Japan

Kazuya Kuraoka, Shunji Matsumura, Yuichi Sanada, Kei Nakachi, Kazue Imai, Hidetaka Eguchi, Keisuke Matsusaki, Naohide Oue, Hirofumi Nakayama, Wataru Yasui
Pages: 465-470
Published online on: 01 August 2005

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Article

Loss of heterozygosity at 17p13.3-ter, distal to TP53, correlates with negative hormonal phenotype in sporadic breast cancer

Laura Roncuzzi, Irene Brognara, Daniela Baiocchi, Dino Amadori, Anna Gasperi-Campani
Pages: 471-474
Published online on: 01 August 2005

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Article

Induction of apoptosis by Chan Su, a traditional Chinese medicine, in human bladder carcinoma T24 cells

Woo Shin Ko, Tae Yeol Park, Cheol Park, Young Hee Kim, Hwa Jung Yoon, Seung Yeon Lee, Sang Hoon Hong, Byung Tae Choi, Yong Tae Lee, Yung Hyun Choi
Pages: 475-480
Published online on: 01 August 2005

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Article

Docetaxel plus epirubicin as first-line chemotherapy in MBC (KCSG 01-10-05): Phase II trial and the predictive values of circulating HER2 extracellular domain and vascular endothelial growth factor

Seock-Ah Im, Sung-Bae Kim, Moon Hee Lee, Young-Hyuck Im, Kyung Hee Lee, Hong-Suk Song, Myung-Ah Lee, Junglim Lee, Nam-Su Lee, Hae Sun Ham, Tae-You Kim, Yeon Hee Park, Kyung Eun Lee, Kee Won Kim, Jae Hong Seo, Soon Nam Lee, Young Seon Hong, Yung-Jue Bang, Woo-Kun Kim, Hee-Sook Park
Pages: 481-487
Published online on: 01 August 2005

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Article

Antineoplaston induces G1 arrest by PKCα and MAPK pathway in SKBR-3 breast cancer cells

Teruhiko Fujii, Anna M. Nakamura, Goro Yokoyama, Miki Yamaguchi, Kosuke Tayama, Keisuke Miwa, Uhi Toh, Daisuke Kawamura, Kazuo Shirouzu, Hideaki Yamana, Michihiko Kuwano, Hideaki Tsuda
Pages: 489-494
Published online on: 01 August 2005

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Article

Functional analysis of transactivation by mutants of hepatitis B virus X gene in human hepatocellular carcinoma

Masami Minemura, Yukihiro Shimizu, Katsuharu Hirano, Yasuhiro Nakayama, Yoshiharu Tokimitsu, Kazuto Tajiri, Kazuki Yamada, Feng Xue, Terumi Takahara, Akiharu Watanabe, Toshiro Sugiyama
Pages: 495-499
Published online on: 01 August 2005

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Article

Cyclic polylactate inhibited growth of cloned leukemic cells through reducing glycolytic enzyme activities

Tomonori Harada, Masaya Nagasu, Isao Tsuboi, Morimichi Koshinaga, Hitoshi Kanno, Shin Aizawa
Pages: 501-505
Published online on: 01 August 2005

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Article

Molecular mechanism of ursolic acid induced apoptosis in poorly differentiated endometrial cancer HEC108 cells

Yumiko Achiwa, Kiyoshi Hasegawa, Yasuhiro Udagawa
Pages: 507-512
Published online on: 01 August 2005

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Article

Prognostic significance of a combined clinicopathologic score for response to primary systemic therapy in locally advanced breast cancer

Philippe Bertheau, Florence Lerebours, Nicolas Mounier, Anne de Roquancourt, Marc Espié, Philippe Clot, Jean-Marie Servant, Jean-Louis Misset, Michel Marty, Anne Janin
Pages: 513-520
Published online on: 01 August 2005

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Article

Is adjuvant radiotherapy in early stages (FIGO I-II) of epithelial ovarian cancer a treatment of the past?

Ingiridur Skirnisdottir, Sarah Nordqvist, Bengt Sorbe
Pages: 521-529
Published online on: 01 August 2005

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Article

Characterization of estrogen-induced F-box protein FBXO45

Kenichi Yoshida
Pages: 531-535
Published online on: 01 August 2005

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Article

Clinical evaluation of a panel of mRNA markers in the detection of disseminated tumor cells in patients with operable breast cancer

Mario Varangot, Enrique Barrios, Cecilia Sóñora, Bernardo Aizen, Carlos Pressa, Roberto Estrugo, Raúl Lavigna, Ignacio Musé, Eduardo Osinaga, Nora Berois
Pages: 537-545
Published online on: 01 August 2005

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Article

In silico characterization of LZTS3, a potential tumor suppressor

Andreas Teufel, Arndt Weinmann, Peter R. Galle, Ansgar W. Lohse
Pages: 547-551
Published online on: 01 August 2005

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Article

Optimization of PKH67 labeling conditions for proliferation monitoring in daunorubicin-treated leukemic cells

M. Barbier, H. Morjani, K.A. Muirhead, X. Ronot, J. Boutonnat
Pages: 553-559
Published online on: 01 August 2005

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Article

Effect of hyperthermia on uptake and cytotoxicity of cisplatin in cultured murine mammary carcinoma cells

J. Haveman, J. W.J. Bergs, N. A.P. Franken, C. van Bree, L. J.A. Stalpers
Pages: 561-567
Published online on: 01 August 2005

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Article

Polymorphisms in the DNA methyltransferase 3b gene and prostate cancer risk

Rakesh Singal, Partha M. Das, Murugesan Manoharan, Isildinha M. Reis, James J. Schlesselman
Pages: 569-573
Published online on: 01 August 2005

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Article

Expression of S100P protein correlates with and contributes to the tumorigenic capacity of HeLa cervical carcinoma cells

Adriana Gibadulinová, Monika Baráthová, Juraj Kopácek, Alzbeta Hulíková, Silvia Pastoreková, Richard Kettmann, Jaromír Pastorek
Pages: 575-582
Published online on: 01 August 2005

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Article

Effect of estradiol and raloxifene on MUC1 expression and adhesive properties of Ishikawa cells

Anna Paszkiewicz-Gadek, Halina Porowska, Miroslawa Pietruczuk, Jozef Haczynski, Dariusz G. Kisiel, Slawomir Wolczynski
Pages: 583-589
Published online on: 01 August 2005

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Journal Cover
March-2026 Volume 55 Issue 3

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Journal Metrics

Impact Factor: 3.9

CiteScore: 8.3

CiteScore Rank: Q1: #73/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Review Open Access

Collaborative breakthroughs in precision diagnosis and treatment of nasopharyngeal cancer: Biomarker‑driven screening and endoscopic minimally invasive surgery reshape the new paradigm of early intervention (Review)

E Jin, Wang Lin, Xiandong Zeng
Article Number: 53
Published online on: 23 January 2026

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Review Open Access

Key immune cells in the tumor immune microenvironment of colorectal cancer: Roles and research advances (Review)

Ming Qiu, Chongyuan Lan, Minglin Lin, Hui Ma
Article Number: 52
Published online on: 21 January 2026

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Correction Open Access

[Corrigendum] Icaritin acts synergistically with epirubicin to suppress bladder cancer growth through inhibition of autophagy

Xiu-Wu Pan, Lin Li, Yi Huang, Hai Huang, Dan-Feng Xu, Yi Gao, Lu Chen, Ji-Zhong Ren, Jian-Wei Cao, Yi Hong, Xin-Gang Cui
Article Number: 51
Published online on: 21 January 2026

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Review Open Access

Epigenetic mechanisms and therapeutic advances in diffuse midline glioma (Review)

Wenbo Wu, Wenlin Chen, Wenbin Ma, Yu Wang
Article Number: 50
Published online on: 20 January 2026

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Review Open Access

Recapitulating lung cancer metastasis in vitro: Advances in organoid models and challenges in clinical translation (Review)

Jian Jiang, Guomin Dong, Zhiyun Zhang, Xiaoyuan Lei, Fanshu Huang, Suoni Li, Jiequn Ma, Jie Bai, Qian Ge, Hui Wei, Zheng Zhao
Article Number: 49
Published online on: 20 January 2026

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Article Open Access

GPR176 enhances the epithelial‑mesenchymal transition in gastric cancer cells by activating the PI3K/AKT/mTOR signaling pathway

Guangchuan Mu, Kaiyan Li, Chaozhen Hu, Jintao Cai, Huichao Ruan, Guanyu Zhu, Dang Liu
Article Number: 48
Published online on: 19 January 2026

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Article Open Access

HMBOX1 inhibits hepatocellular carcinoma progression via PTPN1 mediated AKT1 phosphorylation

Chenning Zhang, Yu Jiang, Jiahui Liu, Wenyu Zhang, Jie Qi, Qing Wen, Hengli Zhao
Article Number: 47
Published online on: 19 January 2026

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Retraction Open Access

[Retracted] Prognostic significance of miR‑218 in human hepatocellular carcinoma and its role in cell growth

Kangsheng Tu, Chao Li, Xin Zheng, Wei Yang, Yingmin Yao, Qingguang Liu
Article Number: 46
Published online on: 19 January 2026

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Review Open Access

Tumor microenvironment in bone sarcomas: Implications for immunotherapy and emerging therapeutic vulnerabilities (Review)

Wentao Li, Lijun Lv, Yibin Jin, Xin Yuan
Article Number: 45
Published online on: 16 January 2026

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Review Open Access

Immunotherapy after EGFR‑TKI treatment in advanced non‑small cell lung cancer: Current status and future perspectives (Review)

Huiyuan Ma, Longhui Li, Conghan Jiao, Yanyan Cheng, Jiayu He, Chen Jiang, Qian Tong, Dan Yi, Ying Zhang
Article Number: 44
Published online on: 16 January 2026

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Correction Open Access

[Corrigendum] Triptolide inhibits JAK2/STAT3 signaling and induces lethal autophagy through ROS generation in cisplatin‑resistant SKOV3/DDP ovarian cancer cells

Yanying Zhong, Fuyin Le, Jiao Cheng, Chen Luo, Xiali Zhang, Xingwu Wu, Fang Xu, Qi Zuo, Buzhen Tan
Article Number: 43
Published online on: 13 January 2026

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Review Open Access

Role of tumor‑infiltrating lymphocytes and miR‑155 in breast cancer: Insights into carcinogenesis and their potential as prognostic biomarkers (Review)

Miriam Monteiro Alvares‑Vilela, Franciele Schlemmer, Sabrina Simplício de Araújo Romero Ferrari, Mary-Ann Elvina Xavier, Ricardo Titze‑de‑Almeida
Article Number: 42
Published online on: 14 January 2026

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Article Open Access

CDK1 depletion suppresses glioma malignancy through cell cycle pathway regulation: Mechanistic insights from functional and molecular profiling

Yu Wang, Huandi Zhou, Xuetao Han, Dongdong Zhang, Liubing Hou, Haonan Li, Tianyi Fan, Sijie Li, Xiaoying Xue
Article Number: 41
Published online on: 12 January 2026

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Retraction Open Access

[Retracted] Downregulated microRNA‑200a promotes EMT and tumor growth through the Wnt/β‑catenin pathway by targeting the E‑cadherin repressors ZEB1/ZEB2 in gastric adenocarcinoma

Ningning Cong, Ping Du, Anling Zhang, Fajuan Shen, Juan Su, Peiyu Pu, Tao Wang, Jie Zjang, Chunsheng Kang, Qingyu Zhang
Article Number: 40
Published online on: 12 January 2026

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Review Open Access

Advances in targeting KRAS mutations: A promising approach for the treatment of non‑small cell lung cancer (Review)

Upesh Sharma, Jincheng Song, Hemraj Kandu, Yue Zhu, Zhaoxia Dai
Article Number: 39
Published online on: 08 January 2026

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Correction Open Access

[Corrigendum] CXCR6 predicts poor prognosis in gastric cancer and promotes tumor metastasis through epithelial-mesenchymal transition

Jie-Jie Jin, Fa-Xiang Dai, Zi-Wen Long, Hong Cai, Xiao-Wen Liu, Ye Zhou, Qi Hong, Qiong-Zhu Dong, Ya-Nong Wang, Hua Huang
Article Number: 38
Published online on: 05 January 2026

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Journal Cover
April-2026 Volume 55 Issue 4

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Journal Metrics

Impact Factor: 3.9

CiteScore: 8.3

CiteScore Rank: Q1: #73/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

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