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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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September 2005 Volume 14 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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September 2005 Volume 14 Issue 3

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Article

Thymidylate synthase expression levels: A prognostic and predictive role in advanced colorectal cancer

  • Authors:
    • R. Bendardaf
    • H. Lamlum
    • A. Elzagheid
    • R. Ristamäki
    • S. Pyrhönen

  • View Affiliations / Copyright

    Affiliations: Department of Oncology and Radiotherapy, Turku University Hospital, Savitehtaankatu 1, PB 52, FIN-20521, Turku, Finland. riyben@utu.fi
  • Pages: 657-662
    |
    Published online on: September 1, 2005
       https://doi.org/10.3892/or.14.3.657
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Abstract

Thymidylate synthase (TS) is the rate-limiting enzyme in the synthesis of pyrimidine nucleotides, required for DNA synthesis, and is also a critical target for fluoropyrimidines, which are widely used in the treatment of gastrointestinal tumours. We examined TS expression in tumours from 86 patients with advanced colorectal cancer who received one of two chemotherapy regimes (either irinotecan alone or irinotecan and 5-flurouracil with folinic acid). TS expression was determined immunohistochemically in 86 paraffin-embedded primary tumour sections and assessed using image analysis software. TS was significantly associated with survival, with lower levels of TS expression associated with longer patient survival (p=0.02). Patients with an objective response to treatment had a longer median survival than those who did not show an objective response to treatment (p=0.001). A significant association was found between tumour TS expression and response to treatment with 5-FU plus FA with irinotecan (p=0.05). Sixty-four percent of patients with TS expression levels below the median showed an objective (complete or partial) response to treatment while, 38% with TS expression levels above the median responded. Immunohistochemical TS expression levels might be used both as a prognostic marker and to help identify patients who would benefit from 5-FU based regime.

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Copy and paste a formatted citation
Spandidos Publications style
Bendardaf R, Lamlum H, Elzagheid A, Ristamäki R and Pyrhönen S: Thymidylate synthase expression levels: A prognostic and predictive role in advanced colorectal cancer. Oncol Rep 14: 657-662, 2005.
APA
Bendardaf, R., Lamlum, H., Elzagheid, A., Ristamäki, R., & Pyrhönen, S. (2005). Thymidylate synthase expression levels: A prognostic and predictive role in advanced colorectal cancer. Oncology Reports, 14, 657-662. https://doi.org/10.3892/or.14.3.657
MLA
Bendardaf, R., Lamlum, H., Elzagheid, A., Ristamäki, R., Pyrhönen, S."Thymidylate synthase expression levels: A prognostic and predictive role in advanced colorectal cancer". Oncology Reports 14.3 (2005): 657-662.
Chicago
Bendardaf, R., Lamlum, H., Elzagheid, A., Ristamäki, R., Pyrhönen, S."Thymidylate synthase expression levels: A prognostic and predictive role in advanced colorectal cancer". Oncology Reports 14, no. 3 (2005): 657-662. https://doi.org/10.3892/or.14.3.657
Copy and paste a formatted citation
x
Spandidos Publications style
Bendardaf R, Lamlum H, Elzagheid A, Ristamäki R and Pyrhönen S: Thymidylate synthase expression levels: A prognostic and predictive role in advanced colorectal cancer. Oncol Rep 14: 657-662, 2005.
APA
Bendardaf, R., Lamlum, H., Elzagheid, A., Ristamäki, R., & Pyrhönen, S. (2005). Thymidylate synthase expression levels: A prognostic and predictive role in advanced colorectal cancer. Oncology Reports, 14, 657-662. https://doi.org/10.3892/or.14.3.657
MLA
Bendardaf, R., Lamlum, H., Elzagheid, A., Ristamäki, R., Pyrhönen, S."Thymidylate synthase expression levels: A prognostic and predictive role in advanced colorectal cancer". Oncology Reports 14.3 (2005): 657-662.
Chicago
Bendardaf, R., Lamlum, H., Elzagheid, A., Ristamäki, R., Pyrhönen, S."Thymidylate synthase expression levels: A prognostic and predictive role in advanced colorectal cancer". Oncology Reports 14, no. 3 (2005): 657-662. https://doi.org/10.3892/or.14.3.657
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