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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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September 2005 Volume 14 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Medicine International

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Article

New rearrangement t(3;17)(q26.3;q12) in an AML patient with a poor outcome

  • Authors:
    • Maria Luiza Macedo Silva
    • Marcelo Land
    • Anita Heller
    • Eliana Abdelhay
    • Maria do Socorro Pombo-de-Oliveira
    • Raul Ribeiro
    • Gilda Alves
    • Décio Lerner
    • Thomas Liehr

  • View Affiliations / Copyright

    Affiliations: Instituto Nacional do Câncer, INCa, Pra?a da Cruz Vermelha 23, 7° andar, Rio de Janeiro, RJ, Brasil. luizamacedo@inca.gov.br
  • Pages: 663-666
    |
    Published online on: September 1, 2005
       https://doi.org/10.3892/or.14.3.663
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Abstract

In more than 90% of acute promyelocytic leukemia (APL) cases a reciprocal translocation t(15;17)(q22;q12) can be observed. The RARα gene on 17q12 is known to have other translocation partners than PML (in 15q22) in a minority of APL cases. Here, we describe a previously unrecorded chromosomal translocation involving the RARα gene and an unknown partner on chromosome 3. The chromosomal rearrangement was studied in detail by 24-color-FISH using whole chromosome painting probes plus multicolor banding. Thus, the breakpoint could be characterized as t(3;17) (q26;q12). In this case 10% of blasts showed AML-M3 characteristics although typical rearrangements with RARα were not detected by molecular methods. The characterization of the present and other comparable APL-cases with exceptional translocation partners of PML or RARα will help to enlighten the understanding of the pathogenesis of APL.

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Copy and paste a formatted citation
Spandidos Publications style
Macedo Silva ML, Land M, Heller A, Abdelhay E, do Socorro Pombo-de-Oliveira M, Ribeiro R, Alves G, Lerner D and Liehr T: New rearrangement t(3;17)(q26.3;q12) in an AML patient with a poor outcome. Oncol Rep 14: 663-666, 2005.
APA
Macedo Silva, M.L., Land, M., Heller, A., Abdelhay, E., do Socorro Pombo-de-Oliveira, M., Ribeiro, R. ... Liehr, T. (2005). New rearrangement t(3;17)(q26.3;q12) in an AML patient with a poor outcome. Oncology Reports, 14, 663-666. https://doi.org/10.3892/or.14.3.663
MLA
Macedo Silva, M. L., Land, M., Heller, A., Abdelhay, E., do Socorro Pombo-de-Oliveira, M., Ribeiro, R., Alves, G., Lerner, D., Liehr, T."New rearrangement t(3;17)(q26.3;q12) in an AML patient with a poor outcome". Oncology Reports 14.3 (2005): 663-666.
Chicago
Macedo Silva, M. L., Land, M., Heller, A., Abdelhay, E., do Socorro Pombo-de-Oliveira, M., Ribeiro, R., Alves, G., Lerner, D., Liehr, T."New rearrangement t(3;17)(q26.3;q12) in an AML patient with a poor outcome". Oncology Reports 14, no. 3 (2005): 663-666. https://doi.org/10.3892/or.14.3.663
Copy and paste a formatted citation
x
Spandidos Publications style
Macedo Silva ML, Land M, Heller A, Abdelhay E, do Socorro Pombo-de-Oliveira M, Ribeiro R, Alves G, Lerner D and Liehr T: New rearrangement t(3;17)(q26.3;q12) in an AML patient with a poor outcome. Oncol Rep 14: 663-666, 2005.
APA
Macedo Silva, M.L., Land, M., Heller, A., Abdelhay, E., do Socorro Pombo-de-Oliveira, M., Ribeiro, R. ... Liehr, T. (2005). New rearrangement t(3;17)(q26.3;q12) in an AML patient with a poor outcome. Oncology Reports, 14, 663-666. https://doi.org/10.3892/or.14.3.663
MLA
Macedo Silva, M. L., Land, M., Heller, A., Abdelhay, E., do Socorro Pombo-de-Oliveira, M., Ribeiro, R., Alves, G., Lerner, D., Liehr, T."New rearrangement t(3;17)(q26.3;q12) in an AML patient with a poor outcome". Oncology Reports 14.3 (2005): 663-666.
Chicago
Macedo Silva, M. L., Land, M., Heller, A., Abdelhay, E., do Socorro Pombo-de-Oliveira, M., Ribeiro, R., Alves, G., Lerner, D., Liehr, T."New rearrangement t(3;17)(q26.3;q12) in an AML patient with a poor outcome". Oncology Reports 14, no. 3 (2005): 663-666. https://doi.org/10.3892/or.14.3.663
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