New rearrangement t(3;17)(q26.3;q12) in an AML patient with a poor outcome
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- Published online on: September 1, 2005 https://doi.org/10.3892/or.14.3.663
- Pages: 663-666
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Abstract
In more than 90% of acute promyelocytic leukemia (APL) cases a reciprocal translocation t(15;17)(q22;q12) can be observed. The RARα gene on 17q12 is known to have other translocation partners than PML (in 15q22) in a minority of APL cases. Here, we describe a previously unrecorded chromosomal translocation involving the RARα gene and an unknown partner on chromosome 3. The chromosomal rearrangement was studied in detail by 24-color-FISH using whole chromosome painting probes plus multicolor banding. Thus, the breakpoint could be characterized as t(3;17) (q26;q12). In this case 10% of blasts showed AML-M3 characteristics although typical rearrangements with RARα were not detected by molecular methods. The characterization of the present and other comparable APL-cases with exceptional translocation partners of PML or RARα will help to enlighten the understanding of the pathogenesis of APL.
