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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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September 2005 Volume 14 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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September 2005 Volume 14 Issue 3

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Article

Up-regulation of PSF2, a member of the GINS multiprotein complex, in intrahepatic cholangiocarcinoma

  • Authors:
    • Kazutaka Obama
    • Katsuaki Ura
    • Seiji Satoh
    • Yusuke Nakamura
    • Yoichi Furukawa

  • View Affiliations / Copyright

    Affiliations: Laboratory of Molecular Medicine, Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan
  • Pages: 701-706
    |
    Published online on: September 1, 2005
       https://doi.org/10.3892/or.14.3.701
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Abstract

To disclose molecular mechanisms of cholangiocarcinogenesis and to search for novel diagnostic markers and therapeutic targets for cholangiocarcinoma, we previously analyzed gene-expression profiles of 25 intrahepatic cholangiocarcinomas (ICCs) by means of a cDNA microarray re-presenting 27,648 genes. Among the genes frequently up-regulated in the cancer cells, we focused on PSF2 (partner of SLD five 2), a component of the GINS multiprotein complex that plays a crucial role in initiation of DNA replication. Semi-quantitative RT-PCR analysis of clinical samples confirmed high levels of PSF2 expression in the cancer cells, but expression of this gene was barely detectable in normal vital organs. Transfection of ETK-1 and HuH28 cells with short-interfering RNA specific to PSF2 reduced the amount of transcript and suppressed cell growth, suggesting that PSF2 may play an important role in development of cholangio-carcinoma. The findings reported here provide new insights into human cholangiocarcinogenesis and may contribute to the development of novel therapeutic drugs for this type of liver cancer.

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Copy and paste a formatted citation
Spandidos Publications style
Obama K, Ura K, Satoh S, Nakamura Y and Furukawa Y: Up-regulation of PSF2, a member of the GINS multiprotein complex, in intrahepatic cholangiocarcinoma. Oncol Rep 14: 701-706, 2005.
APA
Obama, K., Ura, K., Satoh, S., Nakamura, Y., & Furukawa, Y. (2005). Up-regulation of PSF2, a member of the GINS multiprotein complex, in intrahepatic cholangiocarcinoma. Oncology Reports, 14, 701-706. https://doi.org/10.3892/or.14.3.701
MLA
Obama, K., Ura, K., Satoh, S., Nakamura, Y., Furukawa, Y."Up-regulation of PSF2, a member of the GINS multiprotein complex, in intrahepatic cholangiocarcinoma". Oncology Reports 14.3 (2005): 701-706.
Chicago
Obama, K., Ura, K., Satoh, S., Nakamura, Y., Furukawa, Y."Up-regulation of PSF2, a member of the GINS multiprotein complex, in intrahepatic cholangiocarcinoma". Oncology Reports 14, no. 3 (2005): 701-706. https://doi.org/10.3892/or.14.3.701
Copy and paste a formatted citation
x
Spandidos Publications style
Obama K, Ura K, Satoh S, Nakamura Y and Furukawa Y: Up-regulation of PSF2, a member of the GINS multiprotein complex, in intrahepatic cholangiocarcinoma. Oncol Rep 14: 701-706, 2005.
APA
Obama, K., Ura, K., Satoh, S., Nakamura, Y., & Furukawa, Y. (2005). Up-regulation of PSF2, a member of the GINS multiprotein complex, in intrahepatic cholangiocarcinoma. Oncology Reports, 14, 701-706. https://doi.org/10.3892/or.14.3.701
MLA
Obama, K., Ura, K., Satoh, S., Nakamura, Y., Furukawa, Y."Up-regulation of PSF2, a member of the GINS multiprotein complex, in intrahepatic cholangiocarcinoma". Oncology Reports 14.3 (2005): 701-706.
Chicago
Obama, K., Ura, K., Satoh, S., Nakamura, Y., Furukawa, Y."Up-regulation of PSF2, a member of the GINS multiprotein complex, in intrahepatic cholangiocarcinoma". Oncology Reports 14, no. 3 (2005): 701-706. https://doi.org/10.3892/or.14.3.701
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