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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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September 2005 Volume 14 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

HMGA2 is associated with invasiveness but not a suitable marker for the detection of circulating tumor cells in breast cancer

  • Authors:
    • Gerhild Fabjani
    • Dan Tong
    • Andrea Wolf
    • Sebastian Roka
    • Sepp Leodolter
    • Paul Hoecker
    • Michael Bernhard Fischer
    • Raimund Jakesz
    • Robert Zeillinger

  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, General Hospital of Vienna, Molecular Oncology Group, Waehringer Guertel 18-20, 5Q, A-1090 Vienna, Austria
  • Pages: 737-741
    |
    Published online on: September 1, 2005
       https://doi.org/10.3892/or.14.3.737
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Abstract

Previously, the human high mobility group protein member HMGA2 mRNA was reported to be expressed in peripheral blood of patients with breast cancer, but not in healthy individuals. Expression of HMGA2 in blood was suggested to be an independent indicator of poor prognosis in metastatic breast cancer. These very promising findings propose HMGA2 as a potential marker for the detection of circulating tumor cells in peripheral blood. Therefore, we analyzed peripheral blood specimens from healthy controls and patients with breast tumors for HMGA2 expression using TaqMan® real-time RT-PCR to test if HMGA2 is a suitable marker for the early detection of breast cancer and monitoring therapy response in peripheral blood. Furthermore, we examined the possible involvement of HMGA2 expression in invasion investigated by an in vitro invasion assay using established breast cell lines. HMGA2 expression was detected in peripheral blood of breast cancer patients as well as of healthy individuals. No significant association of HMGA2 expression with any clinical or histopathological data was apparent. However, there was a significant correlation of HMGA2 expression in invasive and non invasive breast cell lines (p=0.0056). Although, HMGA2 obviously contributes to invasion it is not a specific marker for the detection of circulating tumor cells in peripheral blood.

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Copy and paste a formatted citation
Spandidos Publications style
Fabjani G, Tong D, Wolf A, Roka S, Leodolter S, Hoecker P, Fischer MB, Jakesz R and Zeillinger R: HMGA2 is associated with invasiveness but not a suitable marker for the detection of circulating tumor cells in breast cancer. Oncol Rep 14: 737-741, 2005.
APA
Fabjani, G., Tong, D., Wolf, A., Roka, S., Leodolter, S., Hoecker, P. ... Zeillinger, R. (2005). HMGA2 is associated with invasiveness but not a suitable marker for the detection of circulating tumor cells in breast cancer. Oncology Reports, 14, 737-741. https://doi.org/10.3892/or.14.3.737
MLA
Fabjani, G., Tong, D., Wolf, A., Roka, S., Leodolter, S., Hoecker, P., Fischer, M. B., Jakesz, R., Zeillinger, R."HMGA2 is associated with invasiveness but not a suitable marker for the detection of circulating tumor cells in breast cancer". Oncology Reports 14.3 (2005): 737-741.
Chicago
Fabjani, G., Tong, D., Wolf, A., Roka, S., Leodolter, S., Hoecker, P., Fischer, M. B., Jakesz, R., Zeillinger, R."HMGA2 is associated with invasiveness but not a suitable marker for the detection of circulating tumor cells in breast cancer". Oncology Reports 14, no. 3 (2005): 737-741. https://doi.org/10.3892/or.14.3.737
Copy and paste a formatted citation
x
Spandidos Publications style
Fabjani G, Tong D, Wolf A, Roka S, Leodolter S, Hoecker P, Fischer MB, Jakesz R and Zeillinger R: HMGA2 is associated with invasiveness but not a suitable marker for the detection of circulating tumor cells in breast cancer. Oncol Rep 14: 737-741, 2005.
APA
Fabjani, G., Tong, D., Wolf, A., Roka, S., Leodolter, S., Hoecker, P. ... Zeillinger, R. (2005). HMGA2 is associated with invasiveness but not a suitable marker for the detection of circulating tumor cells in breast cancer. Oncology Reports, 14, 737-741. https://doi.org/10.3892/or.14.3.737
MLA
Fabjani, G., Tong, D., Wolf, A., Roka, S., Leodolter, S., Hoecker, P., Fischer, M. B., Jakesz, R., Zeillinger, R."HMGA2 is associated with invasiveness but not a suitable marker for the detection of circulating tumor cells in breast cancer". Oncology Reports 14.3 (2005): 737-741.
Chicago
Fabjani, G., Tong, D., Wolf, A., Roka, S., Leodolter, S., Hoecker, P., Fischer, M. B., Jakesz, R., Zeillinger, R."HMGA2 is associated with invasiveness but not a suitable marker for the detection of circulating tumor cells in breast cancer". Oncology Reports 14, no. 3 (2005): 737-741. https://doi.org/10.3892/or.14.3.737
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